Cytochromes P450 in crustacea

James, Margaret O.; Boyle, Sean M.

doi:10.1016/s0742-8413(98)10036-1

Cited by 75 publications

(73 citation statements)

References 72 publications

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“…polychlorinated biphenyls (PCBs), PAHs are more readily biotran sformed by most organism groups, however, to a greatly varying extent (Cerniglia & Heitkamp, 1989, Livingsto ne, 1992. Like other eucaryotes, marine invertebrates use the cytochrome P-450 monooxygenase or mixed function oxygenase (MFO) enzyme system for the biotransformation of PAHs (James, 1989, den Besten, 1998, James & Boyle, 1998, Lee, 1998, Snyder, 2000. Aside from catalyzing a great variety of endogenous reactions, as for instance the metabolism of steroid hormones and fatty acids (Mansuy, 1998) , Foureman, 1989.…”

Section: Introductionmentioning

confidence: 99%

Effects of sediment organic matter quality on bioaccumulation, degradation, and distribution of pyrene in two macrofaunal species and their surrounding sediment

Granberg

Selck

2007

Marine Environmental Research

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Section: Introductionmentioning

confidence: 99%

Effects of sediment organic matter quality on bioaccumulation, degradation, and distribution of pyrene in two macrofaunal species and their surrounding sediment

Granberg

Selck

2007

Marine Environmental Research

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“…Organisms that are in direct contact with pollutants may be suitable bioindicators (RAJAGURU et al, 2003). Among invertebrates, many crustaceans are able to metabolize xenobiotics such as PAHs due to a well-developed cytochrome P450 enzyme system (JAMES and BOYLE, 1998;LIVINGSTONE, 1998;MARTÍN-DÍAZ et al, 2008). This enzymatic system acts in phase I metabolism by adding functional groups through the oxidation, reduction or hydrolysis of non-reactive xenobiotics, converting them into activated metabolites capable of conjugating with water-soluble groups so as to be excreted by phase II metabolism (LISKA, 1998).…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity of Shallow Waters Near the Brazilian Antarctic Station "Comandante Ferraz" (Eacf), Admiralty Bay, King George Island, Antarctica

et al. 2015

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Series of biomonitoring surveys were undertaken weekly in February 2012 to investigate the genotoxicity of the shallow waters around the Brazilian Antarctic Station "Comandante Ferraz" (EACF). The comet assay was applied to assess the damage to the DNA of hemocytes of the crustacean amphipods Gondogeneia antarctica collected from shallow waters near the Fuel Tanks (FT) and Sewage Treatment Outflow (STO) of the research station, and compare it to the DNA damage of animals from Punta Plaza (PPL) and Yellow Point (YP), natural sites far from the EACF defined as experimental controls. The damage to the DNA of hemocytes of G. antarctica was not significantly different between sites in the biomonitoring surveys I and II. In survey III, the damage to the DNA of animals captured in shallow waters near the Fuel Tanks (FT) and Sewage Treatment Outflow (STO) was significantly higher than that of the control site of Punta Plaza (PPL). In biomonitoring survey IV, a significant difference was detected only between the FT and PPL sites. Results demonstrated that the shallow waters in front of the station may be genotoxic and that the comet assay and hemocytes of G. antarctica are useful tools for assessing genotoxicity in biomonitoring studies of Antarctic marine coastal habitats.

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“…However, direct regulatory role of steroid hormones in reproduction is not obvious in crustaceans as hemolymph lev-els of testosetrone, 17α-hydroxytestosterone and 17β-estradiol did not significantly vary in females M. rosenbergii during the ovarian cycle (Martins et al 2007) as well as in females of Marsupenaeus japonicus Bate, 1888 (Okumura & Sakiyama, 2004). The cytochrome P450 system is responsible for synthesis of steroid hormones and their metabolisation (formation of hydroxylated or dehydrogenated metabolites) in crustaceans but it seems to be different from the pathways known in vertebrates (James & Boyle 1998). Further, enzymes involved in ecdysteroidogenesis might also be involved in metabolism of other steroids but it has not been studied in detail yet.…”

Section: Gonadsmentioning

confidence: 93%

“…Available data provide a clear evidence that crustaceans are vulnerable to diverse chemicals and toxicants in the environment (James & Boyle 1998;Olmstead & LeBlanc 2007;Verslycke et al 2007), thus a range of crustacean species is often used in ecotoxicological research. In particular, compounds and pollutants affecting endocrine homeostasis (i.e., endocrine disruptors) are intensively studied also in crustaceans (Hutchinson 2002;LeBlanc 2007, Rodriguez et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Endocrine regulation of the reproduction in crustaceans: Identification of potential targets for toxicants and environmental contaminants

et al. 2008

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Progress in ecotoxicological research documents that crustaceans are highly vulnerable to diverse chemicals and toxicants in the environment. In particular, pollutants affecting endocrine homeostasis in crustaceans (i.e., endocrine disruptors) are intensively studied, and serious reproductive disorders have been documented. In this review, current knowledge about the endocrine regulation of the crustacean reproduction is put together with the published ecotoxicological data with an attempt to summarize the potential of xenobiotics to affect crustacean reproduction. Following gaps and trends were identified: (1) Studies are required in the field of neurohormone (serotonin and dopamine) regulation of the reproduction and possible modulations by environmental toxicants such as antidepressant drugs. (2) Molting-related parameters (regulated by ecdysteroid hormones) are closely coordinated with the development and reproduction cycles in crustaceans (cross-links with methyl farnesoate signalling), and their susceptibility to toxicants should be studied. (3) Other biochemical targets for xenobiotics were recently discovered in crustaceans and these should be explored by further ecotoxicological studies (e.g., new information about ecdysteroid receptor molecular biology). (4) Some sex steroid hormones known from vertebrates (testosterone, progesterone) have been reported in crustaceans but knowledge about their targets (crustacean steroid receptors) and signalling is still limited. (5) Determination of the sex in developing juveniles (affecting the sex ratio in population) is a sensitive parameter to various xenobiotics (including endocrine disruptors) but its modulation by general environmental stress and non-specific toxicity should be further studied.

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Cytochromes P450 in crustacea

Cited by 75 publications

References 72 publications

Effects of sediment organic matter quality on bioaccumulation, degradation, and distribution of pyrene in two macrofaunal species and their surrounding sediment

Effects of sediment organic matter quality on bioaccumulation, degradation, and distribution of pyrene in two macrofaunal species and their surrounding sediment

Genotoxicity of Shallow Waters Near the Brazilian Antarctic Station "Comandante Ferraz" (Eacf), Admiralty Bay, King George Island, Antarctica

Endocrine regulation of the reproduction in crustaceans: Identification of potential targets for toxicants and environmental contaminants

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