Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients

Gallegos‐Arreola, Martha Patricia; Batista-González, Cecilia M.; Delgado-Lamas, José Luis; Figuera, Luis E.; Puebla-Pérez, Ana Marı́a; Arnaud-López, L.; Peralta-Leal, Valeria; Ramírez-Jirano, Luis Javier; Zúñiga‐González, Guillermo Moisés

doi:10.1016/j.bcmd.2004.07.002

Cited by 20 publications

(8 citation statements)

References 23 publications

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“…These reports documented that some combinations of metabolic enzyme genotypes possessed an evident dose-gene effect on the occurrence of acute leukemias. Joseph et al (2004) and Gallegos-Arreola et al (2004) revealed that the genetic variations of CYP1A1, CYP2D6, GSTM1 or GSTT1 appeared to influence susceptibility of ALL in Indian and Mexican people, respectively. Moreover, the genetic variants of CYP2E1, CYP2D6 and GSTM1 'null' were found that contributed to development of acute leukemias in the Turkish population (Aydin-Sayitoglu et al, 2006).…”

Section: Discussionmentioning

confidence: 97%

Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility

Chen¹,

Hu²,

Liu³

et al. 2008

European Journal of Cancer Prevention

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The genetic polymorphisms of biotransformation phase I enzymes, cytochrome P450 (CYP1A1 and CYP2D6), and phase II enzymes, glutathione S-transferase (GSTM1 and GSTT1), were analyzed in 204 healthy persons and 348 leukemia patients, who suffered from also acute lymphoblastic leukemia (ALL), acute nonlymphoblastic leukemia (ANLL) chronic myelogenous leukemia (CML), from the Han ethnic group in Changsha City of Hunan Province of China. Our results showed that the frequencies of polymorphisms of CYP1A1, CYP2D6 and GSTT1 among the groups including acute lymphoblastic leukemia, ANLL, chronic myelogenous leukemia and healthy control have no significant differences. The variation of GSTM1-null genotype alone correlated with the development of ANLL. The combined genotypes of GSTM1-null with GSTT1-null, or GSTM1-null with CYP1A1 heterozygous mutant, or GSTM1-null with CYP1A1 heterozygous mutant and CYP2D6 heterozygous mutant, or GSTM1-null with CYP1A1 heterozygous mutant, CYP2D6 heterozygous mutant and GSTT1-null were found in individuals with high risk of ANLL. All these findings suggest that GSTM1-null genotype alone or in coordination with the relevant genotypes of other metabolic enzymes might be susceptibility factors in the etiology of ANLL.

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Section: Discussionmentioning

confidence: 97%

Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility

Chen¹,

Hu²,

Liu³

et al. 2008

European Journal of Cancer Prevention

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“…To our knowledge this is the first investigation that links CYP1A1 polymorphisms to the increased susceptibility of ALL in Hispanic children. Two other studies have found increased risk of cancer susceptibility and CYP1A1 polymorphisms in the Hispanic population, however, both studies report on adult patients with ALL (19,20). The prevalence of the CYP1A1*2A and *2C polymorphisms has been shown to vary among different ethnic groups (21,22).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in CYP1A1 and Ethnic-Specific Susceptibility to Acute Lymphoblastic Leukemia in Children

Swinney

Beuten

Collier

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The U.S. Surveillance Epidemiology and End Results (SEER) registry reports that Hispanic children have the highest incidence of ALL, however, it is unclear if this is due to genetic factors, unique environmental exposures, or both. Previous reports have shown an association between CYP1A1 variants and ALL.Methods: To explore the contribution of CYP1A1 polymorphisms to ALL susceptibility in different ethnic groups, we conducted a case-control analysis in Caucasian, Hispanic, and African-American children.Results: Increased risk of developing ALL was found in the whole sample group for homozygosity of variant alleles at CYP1A1*2C (OR 2.51, 95% CI 1.18-5.33, P ¼ 0.016) and CYP1A1*2B (OR 3.24, 95% CI 1.43-7.34, P ¼ 0.005). Stratified analyses showed increased risks in the Hispanic group (CYP1A1*2A, OR 2.70, 95% CI 1.27-5.74, P ¼ 0.010; CYP1A1*2C, OR 2.47, 95% CI 1.13-5.38, P ¼ 0.023; and CYP1A1*2B, OR 3.28, 95% CI 1.40-7.69, P ¼ 0.006) but not for the other ethnic groups. Hispanic control subjects were significantly more likely to be carriers of variant alleles as compared to Caucasians (P < 0.0001) and African Americans (P ¼ 0.005).Conclusions: Our study suggests that polymorphisms in CYP1A1 may contribute to the increased risk of ALL in Hispanic children due to both their impact on leukemia susceptibility and the increased prevalence of the at-risk alleles in the Hispanic population.Impact: Our study provides a novel and specific link between CYP1A1 polymorphisms and ethnic influence on ALL risk that may help explain varying susceptibilities across groups to environmental toxins. Cancer Epidemiol Biomarkers Prev; 20(7); 1537-42. Ó2011 AACR.

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“…Thus, each group was considered as a separate study for analysis. Lastly, thirteen publications containing fourteen case-control studies were selected [ 24 ], [ 25 ], [ 26 ], [ 27 ], [ 28 ], [ 29 ], [ 30 ], [ 31 ], [ 32 ], [ 33 ], [ 34 ], [ 35 ], [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…There were three groups of Caucasians [ 24 ], [ 27 ], [ 34 ], five of Asians [ 26 ], [ 29 ], [ 31 ], [ 32 ], [ 36 ] and six of mixed ethnicities [ 25 ], [ 28 ], [ 30 ], [ 33 ], [ 35 ] in this meta-analysis. As shown in Table 1 , five groups of AML [ 25 ], [ 27 ], [ 31 ], [ 33 ], [ 36 ] and nine of ALL [ 24 ], [ 25 ], [ 26 ], [ 28 ], [ 29 ], [ 30 ], [ 32 ], [ 34 ], [ 35 ] were included in this study. As for age groups, there were eight childhood ALL [ 24 ], [ 25 ], [ 26 ], [ 29 ], [ 30 ], [ 32 ], [ 34 ], [ 35 ] and one adult ALL [ 28 ] groups in this study.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table 1 , five groups of AML [ 25 ], [ 27 ], [ 31 ], [ 33 ], [ 36 ] and nine of ALL [ 24 ], [ 25 ], [ 26 ], [ 28 ], [ 29 ], [ 30 ], [ 32 ], [ 34 ], [ 35 ] were included in this study. As for age groups, there were eight childhood ALL [ 24 ], [ 25 ], [ 26 ], [ 29 ], [ 30 ], [ 32 ], [ 34 ], [ 35 ] and one adult ALL [ 28 ] groups in this study. All AML studies concerned adult AML.…”

Section: Resultsmentioning

confidence: 99%

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Association between CYP1A1 Ile462Val Variation and Acute Leukemia Risk: Meta-Analyses Including 2164 Cases and 4160 Controls

Zeng

Zhu

et al. 2012

PLoS ONE

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BackgroundPreviously, CYP1A1 Ile462Val polymorphism has been indicated to be a risk factor for several malignancies. Increasing reports have focused on the association of CYP1A1 Ile462Val polymorphisms with susceptibility to acute leukemia and have generated controversial results. The goal of the present study was to derive a more precise estimation of the relationship.MethodsRelevant literature has been rigorously searched and screened. Eligible studies were identified for the period up to Apr 2012. Meta-analyses evaluating the association of CYP1A1 Ile462Val variation with acute leukemia were carried out. Subgroup analyses on ethnicity, clinical types and source of controls were further performed.ResultsA total of thirteen publications including fourteen case-control studies with 2164 cases and 4160 controls were selected for analysis. The overall data indicated a significant association of CYP1A1 Ile462Val polymorphism with acute leukemia risk (Val/Val vs Ile/Ile OR = 1.49; 95% CI = 1.11–1.98; dominant model: OR = 1.26; 95% CI = 1.05–1.51; recessive model: OR = 1.38; 95% CI = 1.04–1.83). In subgroup analysis on ethnicity, increased risk was shown among mixed ethnicities (Val/Val vs Ile/Ile: OR = 2.36; 95% CI = 1.46–3.82; dominant model: OR = 1.37; 95% CI = 1.01–1.86; recessive model: OR = 2.20; 95% CI = 1.37–3.53) but not Asians or Caucasians. In subgroup analysis on clinical types, increased risk was observed in the acute lymphocytic leukemia (ALL) subgroup (Val/Val vs Ile/Ile: OR = 2.06; 95% CI = 1.42–3.01; recessive model: OR = 1.91; 95% CI = 1.32–2.76) but not in the acute myeloid leukemia (AML) subgroup.ConclusionThe results of the present study suggest that CYP1A1 Ile462Val polymorphism might be a low-penetrant risk factor for acute leukemia. Subgroup analyses suggest that homozygous Val/Val alleles might modify the susceptibility to ALL.

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Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients

Cited by 20 publications

References 23 publications

Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility

Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility

Polymorphisms in CYP1A1 and Ethnic-Specific Susceptibility to Acute Lymphoblastic Leukemia in Children

Association between CYP1A1 Ile462Val Variation and Acute Leukemia Risk: Meta-Analyses Including 2164 Cases and 4160 Controls

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