Cytochrome P450-isoenzyme 1A1 in susceptibility to tobacco-related lung cancer

Abstract

Carcinogens in smoke increase cytochrome P450 1A1 activity, which might be considered to play a role in cigarette smoking-induced lung cancer.

Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

“…AHH, also known as cytochrome P4501A1, is a valuable biomarker for the early diagnosis of lung cancer [45]. The activity and expression of AHH are induced through the activation of the aryl hydrocarbon receptor (AhR) by PAHs [46].…”

M2 polarized macrophages induced by CSE promote proliferation, migration, and invasion of alveolar basal epithelial cells

“…Lung cancer is the most frequently occurring malignant cancer and is the leading cause of cancer death worldwide [15,16]. Cigarette smoke contains more than 100 different mutagens and carcinogens and is the cause of approximately 90% of lung cancer cases [16,17].…”

“…Cigarette smoke contains more than 100 different mutagens and carcinogens and is the cause of approximately 90% of lung cancer cases [16,17]. Recently, it has been reported that TAMs can promote tumor progression, and an abundance of M2 macrophages have been found to infiltrate solid lung tumors, a characteristic that is associated with poor prognosis [18][19][20].…”

<p>Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice</p>

“…The transformation of BaP into BPDE initiates the process of carcinogenesis by DNA adduct formation. [38][39][40] A significant reduction (p<0.0001) in the activity of AHH by DAS was observed in the serum as compared to BaP-exposed mice. The effect of DAS in the downregulation of CYP1A1 mRNA was reported in the lung and liver induced by methylcholanthrene.…”