Cytochrome P450 genes expression in human prostate cancer

Maksymchuk, Oksana; Gerashchenko, Ganna; Rosohatska, Inna; Kononenko, Oleksiy; Tymoshenko, Andriy; Stakhovsky, Eduard; Kashuba, Volodymyr

doi:10.1016/j.ymgmr.2024.101049

Cited by 3 publications

(1 citation statement)

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“…This metabolic process is catalyzed by an enzyme called CYP7B1, which belongs to the cytochrome P450 family. CYP7B1 is primarily expressed in the liver and is involved in the metabolism of steroid hormones [4], playing a critical role in regulating the cell cycle, as well as the proliferative, invasive, and migratory activity of cancer cells [5,6].…”

Section: Introductionmentioning

confidence: 99%

CYP7B1 as a Biomarker for Prostate Cancer Risk and Progression: Metabolic and Oncogenic Signatures (Diagnostic Immunohistochemistry Analysis by Tissue Microarray in Prostate Cancer Patients—Diamond Study)

Russo,

Durukan,

Asmundo

et al. 2024

IJMS

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We aimed to analyze the association between CYP7B1 and prostate cancer, along with its association with proteins involved in cancer and metabolic processes. A retrospective analysis was performed on 390 patients with prostate cancer (PC) or benign prostatic hyperplasia (BPH). We investigated the interactions between CYP7B1 expression and proteins associated with PC and metabolic processes, followed by an analysis of the risk of biochemical recurrence based on CYP7B1 expression. Of the 139 patients with elevated CYP7B1 expression, 92.8% had prostate cancer. Overall, no increased risk of biochemical recurrence was associated with CYP7B1 expression. However, in a non-diabetic subgroup analysis, higher CYP7B1 expression indicated a higher risk of biochemical recurrence, with an HR of 1.78 (CI: 1.0–3.2, p = 0.05). PC is associated with elevated CYP7B1 expression. In a subgroup analysis of non-diabetic patients, elevated CYP7B1 expression was associated with an increased risk of biochemical recurrence, suggesting increased cancer aggressiveness.

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Section: Introductionmentioning

confidence: 99%