Cytochrome P450 enzymes in the kidney of the bobwhite quail (Colinus virginianus): induction and inhibition by ergosterol biosynthesis inhibiting fungicides

Ronis, Martin J. J.; Celander, Malin; Badger, Thomas M.

doi:10.1016/s0742-8413(98)10043-9

Cited by 23 publications

(22 citation statements)

References 23 publications

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“…Inhibition of CYP1A is supported in the present study, showing that ketoconazole was a potent non-competitive inhibitor of EROD activity in vitro . Ketoconazole and other imidazoles also have been shown to be potent inhibitors of EROD activities in other vertebrates [9,13,14,42]. …”

Section: Discussionmentioning

confidence: 99%

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Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)

et al. 2005

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Background: Xenoestrogens and antifungal azoles probably share a common route of metabolism, through hepatic cytochrome P450 (CYP) enzymes. Chemical interactions with metabolic pathways may affect clearance of both xenobiotics and endobiotics. This study was carried out to identify possible chemical interactions by those substances on CYP1A and CYP3A, in Atlantic cod liver. We investigated effects of two xenoestrogens (nonylphenol and ethynylestradiol) and of the model imidazole ketoconazole, alone and in combination.

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Section: Discussionmentioning

confidence: 99%

“…Azole fungicides induce expression of multiple vertebrate CYP genes including members of the CYP1A, CYP2B and CYP3A subfamilies [8,9,13,36-38]. Clotrimazole activates the ligand-binding domain of the PXR, involved in CYP3A signalling, in vitro from several mammalian species and zebra fish ( Danio rerio ) [39].…”

Section: Introductionmentioning

confidence: 99%

Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)

et al. 2005

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“…The chemicals 4-nonylphenol [69], propiconazole [70], and bisphenol A [71], have elicited effects in crustaceans consistent with anti-ecdysteroidal activity. The fungicides propiconazole [72] and fenarimol [73] inhibit cytochromeP450 (CYP) enzymes that are critical to ecdysteroid synthesis. Both of these chemicals may inhibit ecdysteroidsynthesis through this enzyme inhibition.…”

Section: Toxicity Of Chemicals That Mediated Endocrine Disruption On mentioning

confidence: 99%

Crustacean Molting: Regulation and Effects of Environmental Toxicants

Hosamani¹,

B²,

P³

2017

J Marine Sci Res Dev

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In crustaceans the growth of the animal occurs by shedding of old exoskeleton and formation of new exoskeleton. Immediately after ecdysis the newly synthesized cuticle up takes water to expand new exoskeleton thereby size. Molt cycle in crustaceans is under the control of several regulatory hormones, internal and external factors. The predominant hormones molt inhibiting hormone (MIH) and ecdysteroids act in a controversy manner to one another in regulation of molt. It is also identified that the methyl farnesoate (MF) induces molting by inducing the synthesis and release of ecdysteroids from Y-organs. Besides several other hormones and internal molecules like opioids and neurotransmitters along with toxicants (xenobiotics, chemicals and metals) are also involved in the regulation of crustacean molting. Toxicity of aquatic pollutants leads to retardation of growth and delays molting, besides influence mortality and causes huge loss to crustacean farming. This review presents the advances in the field of crustacean molting and its regulation.

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“…The chemicals 4-nonylphenol (Shurin and Dodson 1997;LeBlanc et al 2000), propiconazole (Kast-Hutcheson et al 2001), and bisphenol A (Mu et al 2005), have elicited effects in crustaceans consistent with anti-ecdysteroidal activity. The fungicides propiconazole (Ronis et al 1998) and fenarimol (Williams et al 2000) inhibit cytochrome P450 (CYP) enzymes that are critical to ecdysteroid synthesis. Both of these chemicals may inhibit ecdysteroid synthesis through this enzyme inhibition.…”

Section: Aberrant Ecdysteroid Signalingmentioning

confidence: 99%

Crustacean endocrine toxicology: a review

2007

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Crustaceans are major constituents to aquatic ecosystems that provide a variety of ecological and economic services. Individual crustacean species are adept at occupying diverse niches and their success, in part, stems from neuro-endocrine signaling cascades that regulate physiology in response to environmental and internal cues. Peptide hormones are major signal transducers in crustaceans. The crustacean hyperglycemic hormone family of peptides regulates various aspects of growth, reproduction, and metabolism. These peptides may function as the terminal hormone to regulate some physiological activities or may function as intermediates in a signaling cascade. Ecdysteroids and terpenoids are two major classes of terminal signaling molecules in these cascades. Hormones from these two classes function independently or in concert to regulate various processes. Ecdysteroid signaling is subject to toxicological disruption through disturbances in ecdysteroid synthesis or binding of toxicants to the ecdysteroid receptor. Methyl farnesoate is the major terpenoid hormone of crustaceans and also is susceptible to disruption by environmental chemicals. However, the methyl farnesoate signaling pathway is poorly understood and only limited mechanistic confirmation for disruption of this endocrine signaling pathway exists. Disruption of the ecdysteroid/terpenoid signaling pathways in crustaceans has been associated with aberrations in growth, metamorphosis, reproductive maturation, sex determination, and sex differentiation. Population studies have revealed disruptions in crustacean growth, molting, sexual development, and recruitment that are indicative of environmental endocrine disruption. However, environmental factors other that pollution (i.e., temperature, parasitism) also can elicit these effects and definitive causal relationships between endocrine disruption in field populations of crustaceans and chemical pollution is generally lacking.

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Cytochrome P450 enzymes in the kidney of the bobwhite quail (Colinus virginianus): induction and inhibition by ergosterol biosynthesis inhibiting fungicides

Cited by 23 publications

References 23 publications

Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)

Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)

Crustacean Molting: Regulation and Effects of Environmental Toxicants

Crustacean endocrine toxicology: a review

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