Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans

Schäfer, Patrick; Müller, M.; Krüger, Angela; Steinberg, Christian E. W.; Menzel, Ralph

doi:10.1016/j.abb.2009.06.016

Cited by 31 publications

(28 citation statements)

References 39 publications

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“…Within the C . elegans genome, 81 full length cytochrome P450 (CYP) genes have been found, but the exact biological functions of the vast majority of CYPs are largely unknown as of yet [30]. Only 38 of the 81 CYPs may play a role in lipid metabolism, based on our findings from KEGG, WormBase, and the published literature.…”

Section: Resultsmentioning

confidence: 99%

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

et al. 2013

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BackgroundAnimal models are indispensable to understand the lipid metabolism and lipid metabolic diseases. Over the last decade, the nematode Caenorhabditis elegans has become a popular animal model for exploring the regulation of lipid metabolism, obesity, and obese-related diseases. However, the genomic and functional conservation of lipid metabolism from C. elegans to humans remains unknown. In the present study, we systematically analyzed genes involved in lipid metabolism in the C. elegans genome using comparative genomics.ResultsWe built a database containing 471 lipid genes from the C. elegans genome, and then assigned most of lipid genes into 16 different lipid metabolic pathways that were integrated into a network. Over 70% of C. elegans lipid genes have human orthologs, with 237 of 471 C. elegans lipid genes being conserved in humans, mice, rats, and Drosophila, of which 71 genes are specifically related to human metabolic diseases. Moreover, RNA-mediated interference (RNAi) was used to disrupt the expression of 356 of 471 lipid genes with available RNAi clones. We found that 21 genes strongly affect fat storage, development, reproduction, and other visible phenotypes, 6 of which have not previously been implicated in the regulation of fat metabolism and other phenotypes.ConclusionsThis study provides the first systematic genomic insight into lipid metabolism in C. elegans, supporting the use of C. elegans as an increasingly prominent model in the study of metabolic diseases.

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Section: Resultsmentioning

confidence: 99%

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

et al. 2013

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“…Our results showing an inverse relationship between helminths (which, unlike protozoa, strongly could disrupt their hosts' food absorption), and DL-PCBs burden reinforce such a possibility. Moreover, it has been described that parasites seem to be able to metabolize PCBs through cytochrome P-450 (Menzel et al, 2007;Schafer et al, 2009). This ability would mediate the biotransformation of certain pollutants, and therefore this would reduce the total body burden of residues in the host.…”

Section: Parasites In Feces (mentioning

confidence: 99%

Relationship of polychlorinated biphenyls (PCBs) with parasitism, iron homeostasis, and other health outcomes: Results from a cross-sectional study on recently arrived African immigrants

Henríquez-Hernández

Boada

Pérez-Arellano

et al. 2016

Environmental Research

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“…In order to clarify the relative role of CYP1A1 and CYP1B1 in bioactivation of aromatic hydrocarbons (polycyclic aromatic hydrocarbon [PAH]) in the human lung, Uppstad et al (2010) There are a growing number of studies utilizing RNAi to defi ne the role of nonhuman drug metabolizing enzymes in biotransformation of endobiotics and xenobiotics (Menzel et al, 2005 ;Kulas et al, 2008 ;Benenati et al, 2009 ;Schaefer et al, 2009 ).…”

Section: Applications In Delineating the Transporter Function In Drugmentioning

confidence: 99%

Applications of iRNA Technologies in Drug Transporters and Drug Metabolizing Enzymes

Liao

Xia

2012

ADME‐Enabling Technologies in Drug Design and Development

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Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans

Cited by 31 publications

References 39 publications

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

Relationship of polychlorinated biphenyls (PCBs) with parasitism, iron homeostasis, and other health outcomes: Results from a cross-sectional study on recently arrived African immigrants

Applications of iRNA Technologies in Drug Transporters and Drug Metabolizing Enzymes

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