Cytochrome P‐450 expression and lipid peroxidation in gallbladder cancer

Pandey, Manoj; Sharma, Lal B; Shukla, Vijay K.

doi:10.1002/jso.10206

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Our earlier studies had shown association of bacterial infection and salmonella carrier state 10,11,14 , however, as they were done at a time when the human genome was not deciphered, it was proposed that they bring about the carcinogenesis by altering the fatty acid metabolism, bile acid metabolism and through altering lipid peroxidation. [15][16][17][18][19][20][21] It was also proposed that biliary statis is essential for growth of these bacteria in the gallbladder and estrogen and prolactin pathway activation identi ed in the present study suggest that these may lead to biliary stasis by reducing the biliary motility and increasing the transit time. Further, identi cation of these lncRNA with ferroptosis also suggest that the hypothesis of lipid peroxidation was also true, as it is one of the mechanisms identi ed is ferroptosis.…”

Section: Discussionmentioning

confidence: 87%

“…12,13 and Salmonella typhi 10,14 . The exact mechanism through which these bacteria's promote the gallbladder carcinogenesis is not well understood, however, it is proposed that this is through regulation of the biliary and extrabiliary bile acid pool, modi cation of the erythrocyte membrane fatty acid pro le and lipid peroxidation beside PTGS2 activation leading to activation in ammation cascade [15][16][17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

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Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s, and is responsible for gallbladder carcinogenesis.

Pandey

Rajpoot

Dixit

et al. 2022

Preprint

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Summary Background Gallbladder cancer is the commonest cancer of the bile duct, the etiopathogenesis is still debatable. Non coding RNAs are implicated in various carcinogenesis however their role in gallbladder cancer is still not clear. Methods Transcriptomic data from gallbladder cancer patients was analyzed for differential expression of long non coding RNA (lncRNA), the data was subjected to cross-species phylogenetic analysis and blast with the bacterial and ancient human genome. Pathway analysis, gene-gene interactions and data and text mining was done for non-conserved non coding genes. Findings Of the 16 lncRNA identified as differentially expressed, 7 were found to be phylogenetically of bacterial origin appeared to be acquired by horizontal gene transfer during evolution. These genes were identified in both Homo heidelbergensis and Homo neanderthalensis with dissimilarities. Functional analysis of these gene showed them to regulate various biological and genetic process that appear to promote gallbladder carcinogenesis. Interpretation This is the first study that shows that 7 of the human lncRNA are probably of bacterial origin and has been passed to Homo sapiens through ancestry and part of these has been acquired during human evaluation. These genes regulate the transcription and post transcriptional vital RNA, protein functions and thus may induce gallbladder carcinogenesis.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s, and is responsible for gallbladder carcinogenesis.

Pandey

Rajpoot

Dixit

et al. 2022

Preprint

Self Cite

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“…Realizing that cure may not be an achievable goal, especially in patients with advanced GBC, several Indian groups are concentrating on the etiopathogenesis and primary prevention of GBC. The Varanasi group has evaluated the role of bacteria in bile, erythrocyte membrane fatty acids, chronic typhoid carriage, heavy metals,, pesticides, diet,, micronutrients, hormonal factors, cytochrome P‐450 expression, and trace elements in the causation of GBC. Indian groups have also been studying alterations in bile composition in patients with GBC .…”

Section: Preventionmentioning

confidence: 99%

Advanced gallbladder cancer: Indian “middle path”

Kapoor

2007

J Hepatobiliary Pancreat Surg

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Gallbladder cancer (GBC) is common in northern India. The western world has a pessimistic attitude towards GBC resulting in inadequate management of even early GBC. At the other extreme is the Japanese aggressivism with high mortality but very few actual long-term survivors. The Indian surgeons have adopted a Buddhist "middle path"--aggressive surgical approach for "less advanced" GBC and non-surgical palliative approach for "more advanced" GBC. We rely heavily on staging laparoscopy to detect metastatic deposits on liver, peritoneum and omentum, and upper gastrointestinal endoscopy (UGIE) to detect duodenal infiltration which indicates unresectability as we do not perform pancreatico-duodenectomy for GBC. Our favoured procedure is extended cholecystectomy (EC) which includes a 2 cm nonanatomical wedge of liver in the GB bed and the lymph nodes in hepatoduodenal ligament, behind the duodenum and head of pancreas and along the hepatic artery to the right of celiac axis. EC can achieve R0 resection in patients with T1-T2 and T3 (fundus/body--hepatic bed type) disease. For T3 (neck--hepatic hilum type) and T4 disease major hepatic resection is required. In selected patients with nodally advanced GBC, a non-curative simple cholecystectomy with post-operative chemoradiotherapy may improve survival. GBC is an "Indian disease" and Indian surgeons have to be prepared to accept the "challenge" of GBC.

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Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s.

Pandey

Rajput

Dixit

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Gallbladder cancer is the commonest cancer of the bile duct, the etiopathogenesis is still debatable. Non coding RNAs are implicated in various carcinogenesis however their role in gallbladder cancer is still not clear. Methods: Transcriptomic data from gallbladder cancer patients was analyzed for differential expression of long non coding RNA (lncRNA), the data was subjected to cross-species phylogenetic analysis and blast with the bacterial and ancient human genome. Pathway analysis, gene-gene interactions and data and text mining was done for non-conserved non coding genes. Findings: Of the 16 lncRNA identified as differentially expressed, 7 were found to be phylogenetically of bacterial origin appeared to be acquired by horizontal gene transfer during evolution. These genes were identified in both Homo heidelbergensis and Homo neanderthalensis with dissimilarities. Functional analysis of these gene showed them to regulate various biological and genetic process that appear to promote gallbladder carcinogenesis. Interpretation: This is the first study that shows that 7 of the human lncRNA are probably of bacterial origin and has been passed to Homo sapiens through ancestry and part of these has been acquired during human evaluation. These genes regulate the transcription and post transcriptional vital RNA, protein functions and thus may induce gallbladder carcinogenesis.

show abstract

Cytochrome P‐450 expression and lipid peroxidation in gallbladder cancer

Cited by 4 publications

References 17 publications

Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s, and is responsible for gallbladder carcinogenesis.

Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s, and is responsible for gallbladder carcinogenesis.

Advanced gallbladder cancer: Indian “middle path”

Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s.

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