Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo

Zhang, Beilu; Luo, Zhong; Liu, Junjie; Ding, Xingwei; Li, Jinghua; Cai, Kun

doi:10.1016/j.jconrel.2014.06.037

Cited by 143 publications

(71 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since Lai et al 44 reported the first redox-responsive DDS using CdS nanoparticles to block the pore entrances of mesoporous silica through a disulfide bond, several capped systems driven by GSH and other reducing agents (such as dithiothreitol, DTT) have been described. To establish redox-responsive DDS, disulfide bonds were absolutely necessary, and the gatekeepers may vary, but mainly based on nanoparticles, 44,45,78,79 supramolecule or biomacromolecule, [80][81][82][83][84][85][86][87][88] and polymers. [89][90][91][92][93][94] Many inorganic nanoparticles have been used as nanovalves to seal the drug molecule into the channels of MSN through covalently functionalizing MSN with disulfide containing linkers, such as CdS, 44 Fe 3 O 4 , 45 gold, 78 and ZnO.…”

Section: Redox-responsive Drug Deliverymentioning

confidence: 99%

“…After the drug-loaded nanoparticles internalized and then escaped from the endosome to diffuse into the cytoplasm of cancer cells, the high concentration of GSH in the cytoplasm leads to the removal of the β-CD/adamantane caps by cleaving the pre-installed disulfide bonds, further promoting the release of drugs from the nanocarriers. 80,81 Similarly, some biomacromolecules including collagen, 84 cytochrome c, 85 peptides, 86 hyaluronic acid, 87 and heparin 88 can also be covalently immobilized onto the surface of MSN through disulfide-containing linker and act as gatekeeper for controlled drug release.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

196

View full text Add to dashboard Cite

Section: Redox-responsive Drug Deliverymentioning

confidence: 99%

mentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

196

View full text Add to dashboard Cite

“…[37] The nitrogen adsorption-desorption isotherms of MSNs exhibited the characteristic type IV isotherms [38] with a BrunauerEmmett-Teller (BET) surface area of 506 m 2 g −1 (Figure 1c). The pore size distribution was found to be 10 ± 1 nm.…”

Section: Cytc Encapsulation and Release Studiesmentioning

confidence: 99%

Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles

Yang

Lamers

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Protein delivery into the cytosol of cells is a challenging topic in the field of nanomedicine, because cellular uptake and endosomal escape are typically inefficient, hampering clinical applications. In this contribution cuboidal mesoporous silica nanoparticles (MSNs) containing disk‐shaped cavities with a large pore diameter (10 nm) are studied as a protein delivery vehicle using cytochrome‐c (cytC) as a model membrane‐impermeable protein. To ensure colloidal stability, the MSNs are coated with a fusogenic lipid bilayer (LB) and cellular uptake is induced by a complementary pair of coiled‐coil (CC) lipopeptides. Coiled‐coil induced membrane fusion leads to the efficient cytosolic delivery of cytC and triggers apoptosis of cells. Delivery of these LB coated MSNs in the presence of various endocytosis inhibitors strongly suggests that membrane fusion is the dominant mechanism of cellular uptake. This method is potentially a universal way for the efficient delivery of any type of inorganic nanoparticle or protein into cells mediated by CC induced membrane fusion.

show abstract

“…Almost all the reports are responsive to pH [111][112][113][114][115][116][117][118], light [85] or redox reactions [119,120], while cancer therapy continues to be the major concern. Different targeting molecules may be used such as folic acid (FA) [5,88,116], guanidine [111] or DNA [120]. The pH-responsive mechanism may be achieved through protonation of the carboxylic groups from the poly(acrylic acid) (PAA) [73] at low pH, making the molecules to collapse on the MSN surface while being insoluble in the media.…”

Section: Macromolecular Layersmentioning

confidence: 99%

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Beltrán-Osuna

Perilla

2015

J Sol-Gel Sci Technol

View full text Add to dashboard Cite

Continuous research in prominent fields such as biotechnology, biomedicine and nanopharmaceutics has brought the development of a widespread class of materials, and studies for mesoporous materials have been exponentially growing lately. The purpose of this review is to provide a useful guide for different materials, methods and configurations that have been reported in the last 5 years for the synthesis of spherical mesoporous silica particles (MSP), in the colloidal size range (1-1000 nm). MSP exhibit several limitations that must be overcome in order to enable their medical and clinical use. Surface modification of these particles will allow getting new promising characteristics of these materials, including better drug release control and biocompatibility improvement. These modified MSP could be potentially used in many biomedical applications, especially for drug delivery systems. Emphasis is made on the pore size, diameter and shape of the final particles since these parameters will establish key characteristics, i.e., drug delivery profile, loading capacity and efficiency. Graphical Abstract Spreading the use of mesoporous silica particles in biomedicine is possible by the improvement of its inner characteristics through surface modification. This may be done by chemical functionalization or by coating with macromolecular layers or brushes, thus creating novel responsive core-shell hybrid composites to be used as carriers for drug delivery applications.

show abstract

Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo

Cited by 143 publications

References 56 publications

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Contact Info

Product

Resources

About