Cytochemical studies of the anterior hypophyses of rats receiving estrogen

Wolfe, J. M.

doi:10.1002/aja.1000850206

Cited by 33 publications

(2 citation statements)

References 28 publications

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“…The involvement of oestrogens in controlling the synthesis of pituitary RNA has been suggested (Wolfe, 1949;Convay & Reece, 1969;Robinson & Leavitt, 1972). The increase induced by ovariectomy, the suppression caused by oestradiol and the fluctuation of the RNA metabolism of the anterior pituitary gland during the oestrous cycle are well known (Valotaire & Duval, 1970).…”

Section: Discussionmentioning

confidence: 99%

Regulation of the Metabolism of Pituitary Nucleic Acids in Female Rats

Biro¹

1980

Journal of Endocrinology

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Ovariectomy caused an increase in the metabolism of pituitary nucleic acids. This effect was reversed in vivo by a biphasic action of oestradiol-17 beta which first facilitated RNA metabolism after 8 h and then inhibited it 16 h after intraperitoneal injection. To analyse the origin of this biphasic effect the roles of LH releasing hormone (LH-RH) and hysterectomy were examined. Incorporation of uridine into the RNA of the anterior pituitary gland of female rats was inhibited both in vivo and in vitro by LH-RH. Hysterectomy augmented the increase in the RNA metabolism caused by ovariectomy whereas steroid-free uterine extracts inhibited the increase significantly. We have concluded that extrapituitary factors may be involved in the effects of oestrogen on the metabolism of pituitary nucleic acids.

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