Cytochemical Redistribution of 5′‐Nucleotidase in the Developing Cat Visual Cortex

Schoen, Siegfried W.; Kreutzberg, Georg W.; Singer, Wolf

doi:10.1111/j.1460-9568.1993.tb00487.x

Cited by 30 publications

(14 citation statements)

References 69 publications

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“…This change in the carbohydrate composition coincides with the redistribution of 5'-nucleotidase from an initial localization within layer IV to a more ubiquitous expression of the enzyme in all cortical layers (Schoen et al, 1990). Moreover, it is correlated with a shift of 5'-nucleotidase from a synaptic to a glial location (Schoen et al, 1993).…”

Section: Discussionmentioning

confidence: 93%

“…In the CNS of adult mammals the enzyme has primarily a glial allocation (Schoen et al, 1993). However, during development the enzyme is found in association with migrating nerve cells (Schoen et al, 1988) and synaptic contacts (Schoen et al, 1991(Schoen et al, , 1993. A close correlation between the distribution pattern of 5'-nucleotidase and developmental processes consisting of activity-dependent changes in synaptic connectivity has been found in the kitten visual cortex.…”

Section: Introductionmentioning

confidence: 97%

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Transient Association of the HNK‐1 Epitope with 5′‐Nucleotidase during Development of the Cat Visual Cortex

Vogel

Zimmermann

Singer

1993

Eur J of Neuroscience

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During early postnatal development of the kitten visual cortex the ectoenzyme 5'-nucleotidase undergoes a characteristic redistribution. Until about postnatal week 6 it is essentially confined to synaptic contacts in input layer IV and its expression is related to the use-dependent segregation of thalamic afferents into ocular dominance columns. Subsequently, 5'-nucleotidase becomes distributed uniformly throughout all layers and is then associated selectively with glial cells. Here we describe an age-dependent alteration in the expression of a carbohydrate epitope of 5'-nucleotidase which correlates with the developmental change of the enzyme's localization. We have isolated 5'-nucleotidase from the occipital cortex of kittens of varying age and from adult cats and investigated by immunoblotting the association of the HNK-1 carbohydrate epitope with the protein. 5'-Nucleotidase carries the HNK-1 epitope in kittens of 3-9 weeks but the epitope is absent from 12-week-old kittens or adult cats. Thus, the appearance of the HNK-1 epitope correlates with the transient localization of the enzyme at synapses. The HNK-1 carrying 5'-nucleotidase may be involved in synaptogenesis and use-dependent modifications of synaptic connections.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Transient Association of the HNK‐1 Epitope with 5′‐Nucleotidase during Development of the Cat Visual Cortex

Vogel

Zimmermann

Singer

1993

Eur J of Neuroscience

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“…An impressive correlation has been found between the development of the kitten visual cortex and the distribution of ecto-5′-nucleotidase [161,162]. Within postnatal weeks 4 to 6, the enzyme exhibits a patchy distribution that is related to the terminal fields of the afferents from the two eyes that segregate during this phase to form ocular dominance columns.…”

Section: Ecto-5′-nucleotidasementioning

confidence: 95%

Nucleotide signaling in nervous system development

Zimmermann

2006

Pflugers Arch - Eur J Physiol

156

124

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The development of the nervous system requires complex series of cellular programming and intercellular communication events that lead from the early neural induction to the formation of a highly structured central and peripheral nervous system. Neurogenesis continuously takes place also in select regions of the adult mammalian brain. During the past years, a multiplicity of cellular control mechanisms has been identified, ranging from differential transcriptional mediators to inducers or inhibitors of cell specification or neurite outgrowth. While the identification of transcription factors typical for the stage-specific progression has been a topic of key interest for many years, less is known concerning the potential multiplicity of relevant intercellular signaling pathways and the fine tuning of epigenetic gene regulation. Nucleotide receptors can induce a multiplicity of cellular signaling pathways and are involved in multiple molecular interactions, thus opening the possibility of cross talk between several signaling pathways, including growth factors, cytokines, and extracellular matrix components. An increasing number of studies provides evidence for a role of nucleotide signaling in nervous system development. This includes progenitor cell proliferation, cell migration, neuronal and glial cellular interaction and differentiation, and synaptic network formation.

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“…5 0 -Nucleotidase shows a marked redistribution during development of the cat visual cortex and is thought to be involved in the remodeling of ocular dominance columns [105]. A later electron microscopic study by the same group has suggested that synapse-bound 5 0 -nucleotidase activity plays a role in synaptic malleability during development; its later association with glial cell profiles may reflect other functions for this enzyme [106]. At 30 and 35 days of gestation of fetal guinea-pigs, 5 0 -nucleotidase levels were low, but increased rapidly during the 40 to 60-day period; in contrast, adenosine deaminase was present at 30 days gestation and remained at the same level until 60 days [107].…”

Section: Central Nervous Systemmentioning

confidence: 99%

Purinergic signaling in embryonic and stem cell development

Burnstock

Ulrich

2011

Cell. Mol. Life Sci.

112

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Nucleotides are of crucial importance as carriers of energy in all organisms. However, the concept that in addition to their intracellular roles, nucleotides act as extracellular ligands specifically on receptors of the plasma membrane took longer to be accepted. Purinergic signaling exerted by purines and pyrimidines, principally ATP and adenosine, occurs throughout embryologic development in a wide variety of organisms, including amphibians, birds, and mammals. Cellular signaling, mediated by ATP, is present in development at very early stages, e.g., gastrulation of Xenopus and germ layer definition of chick embryo cells. Purinergic receptor expression and functions have been studied in the development of many organs, including the heart, eye, skeletal muscle and the nervous system. In vitro studies with stem cells revealed that purinergic receptors are involved in the processes of proliferation, differentiation, and phenotype determination of differentiated cells. Thus, nucleotides are able to induce various intracellular signaling pathways via crosstalk with other bioactive molecules acting on growth factor and neurotransmitter receptors. Since normal development is disturbed by dysfunction of purinergic signaling in animal models, further studies are needed to elucidate the functions of purinoceptor subtypes in developmental processes.

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Cytochemical Redistribution of 5′‐Nucleotidase in the Developing Cat Visual Cortex

Cited by 30 publications

References 69 publications

Transient Association of the HNK‐1 Epitope with 5′‐Nucleotidase during Development of the Cat Visual Cortex

Transient Association of the HNK‐1 Epitope with 5′‐Nucleotidase during Development of the Cat Visual Cortex

Nucleotide signaling in nervous system development

Purinergic signaling in embryonic and stem cell development

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