Cytochemical observations on glucose-6-phosphatase, glucosan phosphorylase, glucose-6-phosphate dehydrogenase, and α-glycerophosphate dehydrogenase in chick liver cell cultures infected with Trichomonas vaginalis

Sharma, Narsingh N.; Honigberg, B. M.

doi:10.1016/0020-7519(71)90048-8

Cited by 2 publications

(1 citation statement)

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“…Honigberg's research into trichomonal pathogenesis provided much of the groundwork for later researchers. While searching for a virulence assay (62, 131), Honigberg and coworkers used microscopy and biochemical analysis to define trichomonad structure and function (89,132,169,(300)(301)(302) as well as many behavioral and cytochemical interactions between the parasite and the host cell (129,(262)(263)(264). Modern research has focused on the initial events required to establish infection.…”

Section: Pathogenesismentioning

confidence: 99%

Clinical and Microbiological Aspects ofTrichomonas vaginalis

et al. 1998

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SUMMARY Trichomonas vaginalis, a parasitic protozoan, is the etiologic agent of trichomoniasis, a sexually transmitted disease (STD) of worldwide importance. Trichomoniasis is the most common nonviral STD, and it is associated with many perinatal complications, male and female genitourinary tract infections, and an increased incidence of HIV transmission. Diagnosis is difficult, since the symptoms of trichomoniasis mimic those of other STDs and detection methods lack precision. Although current treatment protocols involving nitroimidazoles are curative, metronidazole resistance is on the rise, outlining the need for research into alternative antibiotics. Vaccine development has been limited by a lack of understanding of the role of the host immune response to T. vaginalis infection. The lack of a good animal model has made it difficult to conduct standardized studies in drug and vaccine development and pathogenesis. Current work on pathogenesis has focused on the host-parasite relationship, in particular the initial events required to establish infection. These studies have illustrated that the pathogenesis of T. vaginalis is indeed very complex and involves adhesion, hemolysis, and soluble factors such as cysteine proteinases and cell-detaching factor. T. vaginalis interaction with the members of the resident vaginal flora, an advanced immune evasion strategy, and certain stress responses enable the organism to survive in its changing environment. Clearly, further research and collaboration will help elucidate these pathogenic mechanisms, and with better knowledge will come improved disease control.

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