Cytoarchitecture of the central amygdaloid nucleus of the rat

McDonald, Alexander J.

doi:10.1002/cne.902080409

Cited by 306 publications

(238 citation statements)

References 68 publications

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“…The Golgi studies in the variety of mammals indicated that the lateral part of CE is formed first of all by striatal-like medium-size spiny neurons [3,4,34]. The aspiny interneurons are very rare in this area [34]. Since lateral part of CE contain huge population of SOM-IR cells that suggests that most of them can be of spiny nature [present study and 8,12,24].…”

Section: Discussionmentioning

confidence: 55%

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Somatostatin-like immunoreactivity in the amygdala of the pig.

Równiak

Robak²,

Bogus‐Nowakowska³

et al. 2008

Folia Histochem Cytobiol.

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Abstract:The distribution and morphology of neurons containing somatostatin (SOM) was investigated in the amygdala (CA) of the pig. The SOM-immunoreactive (SOM-IR) cell bodies and fibres were present in all subdivisions of the porcine CA, however, their number and density varied depending on the nucleus studied. The highest density of SOM-positive somata was observed in the layer III of the cortical nuclei, in the anterior (magnocellular) part of the basomedial nucleus and in the caudal (large-celled) part of the lateral nucleus. Moderate to high numbers of SOM-IR cells were also observed in the medial and basolateral nuclei. Many labeled neurons were also consistently observed in the lateral part of the central nucleus. In the remaining CA regions, the density of SOM-positive cell bodies varied from moderate to low. In any CA region studied SOM-IR neurons formed heterogeneous population consisting of small, rounded or slightly elongated cell bodies, with a few poorly branched smooth dendrites. In general, morphological features of these cells clearly resembled the non-pyramidal Golgi type II interneurons. The routine double-labeling studies with antisera directed against SOM and neuropeptide Y (NPY) demonstrated that a large number of SOM-IR cell bodies and fibers in all studied CA areas contained simultaneously NPY. In contrast, co-localization of SOM and cholecystokinin (CCK) or SOM and vasoactive intestinal polypeptide (VIP) was never seen in cell bodies and fibres in any of nuclei studied. In conclusion, SOM-IR neurons of the porcine amygdala form large and heterogenous subpopulation of, most probably, interneurons that often contain additionally NPY. On the other hand, CCK-and/or VIP-IR neurons belonged to another, discrete subpopulations of porcine CA neurons.

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Section: Discussionmentioning

confidence: 55%

“…Similar situation can be observed in the central nucleus. The Golgi studies in the variety of mammals indicated that the lateral part of CE is formed first of all by striatal-like medium-size spiny neurons [3,4,34]. The aspiny interneurons are very rare in this area [34].…”

Section: Discussionmentioning

confidence: 99%

Somatostatin-like immunoreactivity in the amygdala of the pig.

Równiak

Robak²,

Bogus‐Nowakowska³

et al. 2008

Folia Histochem Cytobiol.

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“…4 I) and ACB (Fig. 4 L), which are targets of BL, BM, and LA innervation (Swanson and Petrovich, 1998), had FG-labeled neurons; in the former case, the projection neurons to LHA were concentrated within a distinct zone of the medial CEA [a region that corresponds to the "intermediate subdivision" described by McDonald (1982)] and, in the latter case, in the caudal shell region of the ACB. This distribution of FG labeling is consistent with previous anatomical tracing of projections from those nuclei to LHA (Krettek and Price, 1978;Kita and Oomura, 1982;Zahm et al, 1999).…”

Section: Combined Double-label Fish and Retrograde Detection Of Projementioning

confidence: 93%

Amygdalar and Prefrontal Pathways to the Lateral Hypothalamus Are Activated by a Learned Cue That Stimulates Eating

Petrovich¹,

Holland²,

Gallagher³

2005

J. Neurosci.

175

161

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Experimental animals that are trained to associate a cue with food consumption when hunger prevails will subsequently consume a greater amount of food when that cue is presented under conditions of satiety. Previously, we showed that this phenomenon of conditioned potentiation of feeding is abolished by a neurotoxic lesion that encompasses the basolateral (BL), basomedial (BM), and lateral (LA) nuclei of the amygdala (AMY) and by disconnection of this region and lateral hypothalamus (LHA). Here, we combined immediateearly gene (IEG) and tract-tracing methods to map functional AMY-LHA circuitry that is engaged when potentiated feeding is produced by pavlovian conditioning. Sated rats were assessed for food consumption in the presence of a cue that was paired previously with food (CSϩ), or in the presence of another cue that was never paired with food (CSϪ), in two consecutive tests temporally arranged for activation of the effector IEGs Arc (activity-regulated cytoskeletal protein) and Homer 1a. We examined the selective induction of the IEGs by tests with CSϩ or CSϪ presentations in AMY neurons that project to LHA, as identified with the retrograde tracer FluoroGold. Using the same labeling methods, we also examined neurons in several other forebrain regions, including the prefrontal cortex and nucleus accumbens, that receive strong inputs from BL/BM/LA nuclei and, in turn, innervate the LHA. Our results indicate that a cue that has acquired the ability to promote eating in sated rats (CSϩ) strongly activates a functional network formed by direct pathways from the BL/BM and orbitomedial prefrontal cortex to the LHA.

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“…The nomenclature and the basic description of the morphological characteristics of the rat amygdala nuclei have been described in detail previously (Cassell et al, 1986;Jolkkonen and Pitk€ anen, 1998;Krettek and Price, 1978;McDonald, 1982;Pitk€ anen, 2000;Pitk€ anen et al, 1995;Price et al, 1987;Savander et al, 1995Savander et al, , 1996. We used these descriptions to determine the boundaries of the five main nuclei (i.e., lateral, basal, accessory basal, central, and medial) of the rat amygdala ( Fig.…”

Section: Anatomical Boundaries Of the Amygdalamentioning

confidence: 99%

Postnatal development of the amygdala: A stereological study in rats

Chareyron

Lavenex

2012

J of Comparative Neurology

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The amygdala is the central component of a functional brain system regulating fear and emotional behaviors. Studies of the ontogeny of fear behaviors reveal the emergence of distinct fear responses at different postnatal ages. Here, we performed a stereological analysis of the rat amygdala to characterize the cellular changes underlying its normal structural development. Distinct amygdala nuclei exhibited different patterns of postnatal development, which were largely similar to those we have previously shown in monkeys. The combined volume of the lateral, basal, and accessory basal nuclei increased by 113% from 1 to 3 weeks of age and by an additional 33% by 7 months of age. The volume of the central nucleus increased only 37% from 1 to 2 weeks of age and 38% from 2 weeks to 7 months. At 1 week of age, the medial nucleus was 77% of the 7-monthold's volume and exhibited a constant, marginal increase until 7 months. Neuron number did not differ in the amygdala from 1 week to 7 months of age. In contrast, astrocyte number decreased from 3 weeks to 2 months of age in the whole amygdala. Oligodendrocyte number increased in all amygdala nuclei from 3 weeks to 7 months of age. Our findings revealed that distinct amygdala nuclei exhibit different developmental profiles and that the rat amygdala is not fully mature for an extended period postnatally. We identified different periods of postnatal development of distinct amygdala nuclei and cellular components, which are concomitant with the ontogeny of different fear and emotional behaviors.

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Cytoarchitecture of the central amygdaloid nucleus of the rat

Cited by 306 publications

References 68 publications

Somatostatin-like immunoreactivity in the amygdala of the pig.

Somatostatin-like immunoreactivity in the amygdala of the pig.

Amygdalar and Prefrontal Pathways to the Lateral Hypothalamus Are Activated by a Learned Cue That Stimulates Eating

Postnatal development of the amygdala: A stereological study in rats

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