Cytoarchitectonically‐driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging

Kyle, Colin T.; Stokes, Jared; Bennett, Jeffrey; Meltzer, J.; Permenter, Michele R.; Vogt, Julie; Ekstrom, Arne D.; Barnes, Carol A.

doi:10.1002/hipo.22809

Cited by 5 publications

(4 citation statements)

References 49 publications

(79 reference statements)

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“…Neurovault.org provides a unified place for sharing and visualizing location-based resources, including masks and regional atlases. For example, Kyle et al (2019) , provided a cytoarchitectonically defined atlas of nonhuman primate hippocampus ( Fig. 3 B ).…”

Section: Resultsmentioning

confidence: 99%

Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault

et al. 2021

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Animal neuroimaging studies can provide unique insights into brain structure and function, and can be leveraged to bridge the gap between animal and human neuroscience. In part, this power comes from the ability to com bine mechanistic interventions with brain-wide neuroimaging. Due to their phylogenetic proximity to humans, nonhuman primate neuroimaging holds particular promise. Because nonhuman primate neuroimaging studies are often underpowered, there is a great need to share data amongst translational researchers. Data sharing efforts have been limited, however, by the lack of standardized tools and repositories through which nonhuman neuroimaging data can easily be archived and accessed. Here, we provide an extension of the Neurovault framework to enable sharing of statistical maps and related voxelwise neuroimaging data from other species and template-spaces. Neurovault, which was previously limited to human neuroimaging data, now allows researchers to easily upload and share nonhuman primate neuroimaging results. This promises to facilitate open, integrative cross-species science while affording researchers the increased statistical power provided by data aggregation. In addition, the Neurovault code-base now enables the addition of other species and template-spaces. Together, these advances promise to bring neuroimaging data sharing to research in other species, for supplemental data location-based atlases, and data that would otherwise be relegated to a “file-drawer”. As increasing numbers of researchers share their nonhuman neuroimaging data on Neurovault, this resource will enable novel, large-scale, cross-species comparisons that were previously impossible.

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Section: Resultsmentioning

confidence: 99%

Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault

et al. 2021

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“…Subfield delineations were mainly based on previously described criteria in the macaque 114 , which mirror those used in humans and previously for BigBrain 105 . We labelled CA3 and CA4 together as one subfield because the differentiation between the two was not consistently recognisable.…”

Section: Methodsmentioning

confidence: 99%

Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

Eichert,

DeKraker,

Howard

et al. 2024

Nat Commun

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While the hippocampus is key for human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro- and micro-structure, which shows anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species followed an anterior-posterior axis, we observed a marked reconfiguration in the latter across species, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Here we show that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding within heteromodal association networks.

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“…Subfield delineations were based on previously described criteria in the macaque 107 , which mirror those used in the human and previously for BigBrain 98 . We labelled CA3 and CA4 together as one subfield because the differentiation between the two was not consistently recognizable.…”

Section: Star Methodsmentioning

confidence: 99%

Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

Eichert,

DeKraker,

Howard

et al. 2023

Preprint

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The hippocampus is involved in numerous cognitive functions, some of which have uniquely human aspects, such as autobiographical memory. Hippocampal anatomy, however, is typically considered conserved across primates and its evolutionary diversification is rarely studied. Comparing hippocampal structure and function is, therefore, critical for understanding human brain architecture. Here, we developed a novel comparative framework to study the hippocampus across species characterising its geometry, microstructure, and functional network embedding. In humans and macaques, we generated a new comparative space that represents the hippocampus as an unfolded surface, which respects its sheet-like anatomy. We mapped histological and MRI-derived markers of microstructure to the hippocampal surface and integrated it with low-dimensional embedding of resting-state MRI connectivity data. Our results demonstrate that the micro– and macro-structural organisation of the hippocampus are overall conserved in both species, showing consistent anterior-posterior and subfield-to-subfield differentiation. Furthermore, while hippocampal functional organisation also follows anterior-posterior trends in both species, hippocampal functional connectivity markedly reflected evolutionary reconfiguration of transmodal networks, in particular the default-mode network. Specifically, the inferior parietal lobe in the macaque mirrors an incomplete integration of the default mode network in non-human primates. By combining fine-grained anatomical investigation with large-scale functional imaging, we showed that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration, due to their embedding in higher-order association networks.SummaryWhile the hippocampus is key for uniquely human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro– and micro-structure, showing anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species also followed an anterior-posterior axis, the latter showed a marked evolutionary reconfiguration, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Our findings suggest that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding in heteromodal association networks.

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Cytoarchitectonically‐driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging

Cited by 5 publications

References 49 publications

Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault

Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault

Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

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