Cytarabine

El‐Subbagh, Hussein I.; Al-Badr, Abdullah A.

doi:10.1016/s1871-5125(09)34002-9

Cited by 21 publications

(6 citation statements)

References 76 publications

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“…The C=0 stretch vibration (1734 cm −1 ) [42] of the liposome constituent lipids was chosen as the liposome marker band because of its strong intensity and because it does not spectrally overlap with the IR bands of cytarabine and buffer. Similarly, the band at 1528 cm −1 (C=N and C=C vibration of pyrimidines [24,43]) was selected as the cytarabine marker band.…”

Section: Resultsmentioning

confidence: 99%

“…For example, liposomal cytarabine is clinically approved for treating of lymphomatous meningitis [23]. Cytarabine – or cytosine arabinoside (ara- C) - is a chemotherapeutic drug that stops cancer growth by interfering with DNA synthesis by virtue of its close structural/chemical similarity to the DNA nucleoside cytosine deoxyribose [24]. Because liposomes increase the delivery precision of toxic compounds to cancer sites with respect to disease-free tissues, one of their primary benefits is the reduction of side effects [25].…”

Section: Introductionmentioning

confidence: 99%

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Nanoscale chemical imaging of individual chemotherapeutic cytarabine-loaded liposomal nanocarriers

et al. 2018

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Dosage of chemotherapeutic drugs is a tradeoff between efficacy and side-effects. Liposomes are nanocarriers that increase therapy efficacy and minimize side-effects by delivering otherwise difficult to administer therapeutics with improved efficiency and selectivity. Still, variabilities in liposome preparation require assessing drug encapsulation efficiency at the single liposome level, an information that, for non-fluorescent therapeutic cargos, is inaccessible due to the minute drug load per liposome. Photothermal induced resonance (PTIR) provides nanoscale compositional specificity, up to now, by leveraging an atomic force microscope (AFM) tip contacting the sample to transduce the sample’s photothermal expansion. However, on soft samples (e.g. liposomes) PTIR effectiveness is reduced due to the likelihood of tip-induced sample damage and inefficient AFM transduction. Here, individual liposomes loaded with the chemotherapeutic drug cytarabine are deposited intact from suspension via nES-GEMMA (nano-electrospray gas-phase electrophoretic mobility molecular analysis) collection and characterized at the nanoscale with the chemically-sensitive PTIR method. A new tapping-mode PTIR imaging paradigm based on heterodyne detection is shown to be better adapted to measure soft samples, yielding cytarabine distribution in individual liposomes and enabling classification of empty and drug-loaded liposomes. The measurements highlight PTIR capability to detect ≈ 103 cytarabine molecules (≈ 1.7 zmol) label-free and non-destructively.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanoscale chemical imaging of individual chemotherapeutic cytarabine-loaded liposomal nanocarriers

et al. 2018

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“…In 1964, the first clinical trials began and finally, in 1969, after the conclusions of several oncologic groups, Cytarabine (Cytosar-U ® ) obtained FDA approval for the treatment of acute myeloid leukemia [10]. Rapidly, its clinical effectiveness became popular and its use was extended to the treatment of acute meningeal and lymphocytic leukemia, chronic myelogenous leukemia, and lymphoma [134]. The therapeutic relevance of Cytarabine is reflected by its inclusion in the Model List of Essential Medicines of the World Health Organization (https: //www.who.int/medicines/publications/essentialmedicines/en/).…”

Section: Marine Compounds Approved For Cancer Treatmentmentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioactives is an important step for their success in the clinical setting. Such optimization involves chemical modifications to improve their half-life in circulation, potency and tumor selectivity. In this review, we outline the most promising marine bioactives that have been investigated in cancer models and/or tested in patients as anticancer agents. Moreover, we describe the current state of development of anticancer marine compounds and discuss their therapeutic limitations as well as different strategies used to overcome these limitations. The search for new marine antitumoral agents together with novel identification and chemical engineering approaches open the door for novel, more specific and efficient therapeutic agents for cancer treatment.

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“…The influence of functional group nature on catalysts activity in a process of liquidphase hydrogenation of 4-nitroaniline (NA) and sodium maleate was investigated. Both processes were chosen due to its valuable products-1,4-phenylenediamine and sodium succinate [60][61][62][63][64][65][66][67]. Moreover, these processes are well-studied and a good model, as well as structure-sensitive [68][69][70][71][72][73].…”

Section: Introductionmentioning

confidence: 99%

Sol-Gel Synthesis of Organically Modified Silica Particles as Efficient Palladium Catalyst Supports to Perform Hydrogenation Process

et al. 2021

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Modern approaches to the production of new materials require the improvement of synthesis techniques towards simplifying the processes of their preparation and reducing the number of stages. Thus, in this study, one-stage synthesis of organomodified silica materials is developed using a special surfactant—dodecyldimethylamin N-oxide (DDAO). The peculiarity of this approach is that there is no need for heat treatment of the material, since DDAO is removed by washing in alcohol. Amino-, mercapto-, methyl-, and phenyl-modified silicas were synthesized using this method. The SEM images showed the morphology of all the obtained materials is close, all particles are spherical, and the diameter of individual particles is about 500 nm. Palladium particles were precipitated on these supports, then the experiments were carried out to study the catalytic activity of these materials in a model reaction of nitroaniline reduction. The phenyl modified matrix-based materials showed very low activity. This is due to the fact that the support and the substrate contain aromatic fragments, thus, hydrophobic interactions arise between them, which complicates the diffusion of the products. The leader is a matrix with an amino fragment, which is associated with its electron-donor effect. The XPS method revealed the amount of fixed palladium, as well as the binding energy shifts, which are 0.68 eV for 5% Pd/SiO2–C6H5; 0.56 eV for 5% Pd/SiO2–C3H6–NH2; 0.26 eV for 5% Pd/SiO2–CH3; and 0.13 eV for 5% Pd/SiO2.

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Cytarabine

Cited by 21 publications

References 76 publications

Nanoscale chemical imaging of individual chemotherapeutic cytarabine-loaded liposomal nanocarriers

Nanoscale chemical imaging of individual chemotherapeutic cytarabine-loaded liposomal nanocarriers

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Sol-Gel Synthesis of Organically Modified Silica Particles as Efficient Palladium Catalyst Supports to Perform Hydrogenation Process

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