“…RSM designed for model building and calculating statistical relationships between the data obtained from experiments and independent variables directly effects the results of the experiments (Alvarez, 2000). RSM applications are already using for the heavy metal removal from wastewaters (Esfandiar et al, 2014;Tajernia et al, 2014) or determining biosorption of some elements in brown algae like Cystoseira indica (Keshtkar et al, 2019), Cystoseira myricaas (Zarei & Niad, 2017), and Cystoseira trinodis (Salehi et al, 2014). Considering such information, RSM can be used for the reduction of toxic elements along with enhancing beneficial ones in marine algae by manipulating this biochemical process vice versa.…”