Cystosarcoma phyllodes: Pathological enigma: A retrospective review of 162 cases

Narayanakar, RP; Gangaiah, DM; Althaf, Syed; Dev, Kapil; Kurpad, Vishnu; Gurawalia, Jaiprakash

doi:10.4103/0019-509x.176698

Cited by 20 publications

(19 citation statements)

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“…5 It is important to inform the patient with PT about the recurrence and metastatic risk according to the histologic features of the tumour (even if, in some cases, the histological grade alone does not correctly predicts the biological aggressiveness of the tumour and the clinical prognosis). 7,8 After many classifications have been proposed, the 2003 WHO Phylloid tumour classification has been the most widely accepted and commonly used. Considering the poor relation between histologic grade and prognosis, several authors have tried to identify genetic or molecular markers (MED12 mutations, 3 DNA ploidy, 4 collagen type III ␣1, 9 others).…”

Section: Discussionmentioning

confidence: 99%

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Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies

Câmara

González-Farré

Vargas-Moniz

2017

Revista de Senología y Patología Mamaria

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Phyllodes tumour corresponds to 1% of breast primary tumours. Its primary treatment is presently surgical and, for several reasons, it usually requires breast reconstruction. First of all, an important breast volume is often removed, not only because it can easily achieve great dimensions, thanks to it fast growing potential, but also because wide excision is recommended to avoid its frequent but unpredictable local recurrence (meaning that ideal tumour resection margins are unknown). Second, it frequently affects young woman with more aesthetic concerns. We present a case of phyllodes tumour recurrence where oncoplastic surgery was necessary at both episodes and discuss the literature controversies on this subject, mainly related to treatment and prognosis prediction factors.

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Section: Discussionmentioning

confidence: 99%

“…Adjuvant treatment with chemotherapy, 8,14,15 radiotherapy 8,14 or hormonal therapy presently have no clear evidence of benefit and remain controversial. Given the rarity of PT, randomized controlled trials are unexpected.…”

Section: Discussionmentioning

confidence: 99%

Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies

Câmara

González-Farré

Vargas-Moniz

2017

Revista de Senología y Patología Mamaria

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“…The median margin width has not been reported in the literature. Though the incidence of positive/close margin varied from 5.9 to 66.7%, revision surgery was performed only in few [43] 49 (30) 50 ( Age at presentation has also been described as a predictive factor for LR, but the results are contradictory. In a review by Spitaleri et al, it has been shown that young age (<35 years) is a poor prognostic factor for all phyllodes-related events [25] 21 (44) 6 (28.6) [32] 19 (11) 11 (57.9) in both univariate and multivariate analyses.…”

Section: Histological Classificationmentioning

confidence: 95%

“…The median tumor size ranges from 5.2 to 10.8 cm in various studies, and these report 10 cm as the significant cutoff for LR. [8,25,31,39,43] Studies reporting tumor size <5 cm as the significant cutoff have median tumor size in the range of 3.0-6.1 cm. [24,27,31,37] The hazard ratio (HR) has not been reported in most of the studies except in the study by Asoglu et al, where authors have demonstrated tumor size to be an independent predictor of LR in multivariate analysis.…”

Section: Histological Classificationmentioning

confidence: 99%

Phyllodes tumor of the breast: Wolf inside the sheep’s skin!

Wadasadawala¹,

Swain²,

Bajpai³

2016

Oncobiology and Targets

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Phyllodes tumor, previously known as cystosarcoma phyllodes, is a rare fibro-epithelial tumor of breast constituting <1% of all the breast tumors. It is classified into benign, borderline, and malignant subtypes depending upon the histological criteria defined by the World Health Organization and also has an independent prognostic significance. Accurate pretreatment histological diagnosis is important for the optimal management of phyllodes tumor so that low recurrence rates, improved survival, and optimal long-term cosmetic result can be achieved. Despite surgery being the standard of care, the best type of surgery for each histological type is yet to be defined. The higher rate of local recurrence after surgery alone in borderline and malignant phyllodes tumor raises the question regarding the need of adjuvant treatment, especially radiotherapy, which remains underutilized. The perspective of the current review is to provide the state-of-the-art management of phyllodes tumor of the breast and highlight the risk factors associated with recurrence.

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“…Ainda não existem fatores clinicopatológicos que possam predizer a recorrência e mortalidade. 1 A paciente em questão, atualmente, se encontra em acompanhamento para evitar futuras recorrências, por se tratar de paciente jovem de mama densa, foi optado pelo acompanhamento com Ultrassonografia das mamas, que inicialmente foi prescrita ser realizada de 6 em 6 meses por 3 vezes consecutivas.…”

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Tumor Filóides Borderline: Relato de caso

Tepedino¹,

Guimarães²,

Boa³

et al. 2016

R. Saúde

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ResumoO presente artigo tem o objetivo de narrar o caso de uma jovem de 24 anos, que teve quadro de Tumor Filóides do tipo borderline, evidenciado durante cirurgia de excisão de fibroadenoma e diagnosticado por exame histopatológico da lesão, sendo futuramente reabordado com nova cirurgia. O Tumor Filóides é uma neoplasia fibroepitelial incomum da mama, representando de 0,3 a 0,9% de todos os tumores primários daquele órgão. É comumente vista entre pacientes com 40-50 anos, sendo mais raro ainda sua apresentação em jovens. Por fim este artigo apresenta breve revisão de literatura, mostrando que a conduta utilizada no caso foi correta. Palavras-Chave: Tumor filoides; Fibroadenoma; Borderline. Marina Pirassol Tepedino Tumor Filóides Borderline: Relato de Caso e Revisão de Literatura AbstractThis article aims to tell the story of the case of a 24 year-old, who had Phyllodes Tumor frame borderline, evidenced during fibroadenoma excision surgery, and diagnosed by histopathology of the lesion, and later treated with a new surgery. The Phyllodes Tumor is an uncommon fibroepithelial breast cancer, representing 0.3 to 0.9% of all primary tumors of that organ. It is commonly seen among patients 40-50 years. It is even more rare identifies in young people. Finally this paper presents a brief literature review, showing that the strategy used in the case was correct.

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Cystosarcoma phyllodes: Pathological enigma: A retrospective review of 162 cases

Cited by 20 publications

References 1 publication

Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies

Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies

Phyllodes tumor of the breast: Wolf inside the sheep’s skin!

Tumor Filóides Borderline: Relato de caso

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