Cystosarcoma phyllodes of the breast: A malignant and a benign tumor. A clinicopathological study of seventy-seven cases

Treves, Norman; Sunderland, Douglas A.

doi:10.1002/1097-0142(195111)4:6<1286::aid-cncr2820040614>3.0.co;2-t

Cited by 189 publications

(64 citation statements)

References 10 publications

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“…Axillary dissection is not routinely recommend as metastasis to the lymph nodes occur in less than 5% of patients Mastectomy was the preferred treatment of choice in our case as the tumor was two times recurrent having a very large size covering almost whole of the breast. Mastectomy has been the most commonly performed surgery for borderline and malignant PTs with local recurrence rates of 5% and 12%; respectively (15,16,17). Local recurrence is usually seen within the first few years of surgery and histologically resembles the original tumor.…”

Section: Discussion Discussionmentioning

confidence: 99%

Recurrent Giant Phyllodes Tumour in a Young Female: A Case Report

Koshariya¹,

Sharma²,

Gehlot³

et al. 2016

JTMR

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Phyllodes tumors (PTs) are uncommon neoplasms of the breast, constituting 0.3 to 0.9% of all breast tumors in females comprised of both stromal and epithelial elements. The term cystosarcoma phyllode was coined by Johannes Muller, a misleading term as tumors are rarely cystic and the majority follow a benign clinical course. The term giant phyllodes is used when the tumor size exceeds 10 cm in diameter. WHO (World Health Organization) classification has identified three categories of phyllodes tumors of the breast (PT): benign, borderline and malignant. The mainstay of treatment of non-metastatic phyllodes tumors of the breast is complete surgical resection with wide resection margins. Local recurrence up to 50 % after surgery has been reported in Phyllodes tumors. We report a case of two episodes of recurrent phyllodes tumor in a young female.

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Section: Discussion Discussionmentioning

confidence: 99%

Recurrent Giant Phyllodes Tumour in a Young Female: A Case Report

Koshariya¹,

Sharma²,

Gehlot³

et al. 2016

JTMR

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“…2 Since early in this century, it has been recognized that the natural history and clinical behavior of this tumor are different from carcinoma of the breast. The mean age in larger series is in the fourth decade; 6,7 however, there are cases reported in the prepuberty and adolescent period. 8,9 The median age in our series is 45 years, while our youngest patient was 16 years old.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,12,[15][16][17][18] The complex relationship between these variables has led to the formation of several grading systems, none of which could consistently predict the clinical behavior of these tumors. In recent studies from Northwest University (Chicago, II, USA), the use of flow cytometric analysis of DNA aneuploidy and proliferative index correlated with the grading systems.…”

Section: Figure: Projected Five-year Survivalmentioning

confidence: 99%

Malignant Cystosarcoma Phyllodes: A Review of the Clinical Experience at King Faisal Specialist Hospital and Research Centre

Ezzat

Abdulkareem²,

El-Senoussi³

et al. 1994

Annals of Saudi Medicine

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Twelve females with cystosarcoma phyllodes of the breast were referred to King Faisal Specialist Hospital and Research Centre (KFSH&RC) between 1980 and 1990, representing 0.8% of breast cancer patients seen during this period. Median age was 45 years (range 16 to 65 years). Seven patients (58%) were premenopausal. All patients presented with breast mass, which measured >10 cm in 58% of them. The median duration of symptoms was 15 months (range two to 174). Neither axillary lymph nodes nor distant metastases were seen at presentation. Surgery was the cornerstone of primary treatment (wide local excision in three and mastectomy in nine). Two patients received adjuvant chemotherapy and locoregional irradiation. All patients had malignant tumors histologically. Of the four tumors assayed for hormonal receptors, one was positive for estrogen and progesterone receptors. At a median follow-up of 17 months (range two to 77), four patients had relapsed; one died at 19 months and the projected five year survival is 83%. This limited data supports the observation that malignant cystosarcoma phyllodes is a distinctive clinicopathological entity of female breast cancer with a different natural history from carcinoma of the breast. Our survival results are similar to reported experience from the literature.

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“…The term adenofibrosarcoma has been used either synonymously with cystosarcoma phyllodes (Hill and Stout, 1942), or to describe a sarcoma arising in a fibroadenoma (Rogers and Flo, 1942) or for fibrosarcomas of breast containing numerous glandular elements, but with no evidence of benign fibroadenoma (Curran and Dodge, 1962). The majority of spindle cell sarcomas of breast are thought to arise in a pre-existing fibroadenoma (D'Aunoy and Wright, 1930;Treves and Sunderland, 1951;Willis, 1960a;and Stewart, Tumours were placed in group II, if they had a long history of a lump in the breast, the typical macroscopic appearance seen in group I or contained glandular elements but no fibroadenoma.…”

Section: Methodsmentioning

confidence: 99%

“…These figures suggest that sarcoma of breast carried a graver prognosis than suggested by the figures of Curran and Dodge of 8 deaths from sarcomatosis in 39 sarcomas of breast. Treves and Sunderland (1951) found that 8 of their 18 histologically malignant cystosarcomas phyllodes ultimately died of sarcomatosis. The prognosis did not appear to be related to treatment.…”

Section: Prognosis and Treatmentmentioning

confidence: 99%