2011
DOI: 10.1016/j.yexcr.2010.09.012
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Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys

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Cited by 17 publications
(17 citation statements)
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“…Drug-induced growth inhibition is often associated with increased apoptosis in PKD cells, and apoptosis has been implicated in strategies for therapeutic intervention [21]. However, the studies of the effects of rapamycin on apoptosis in PKD are conflicting [26], and the present study showed that rapamycin and everolimus induced apoptosis in PCK cholangiocytes.…”
Section: Discussionmentioning
confidence: 49%
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“…Drug-induced growth inhibition is often associated with increased apoptosis in PKD cells, and apoptosis has been implicated in strategies for therapeutic intervention [21]. However, the studies of the effects of rapamycin on apoptosis in PKD are conflicting [26], and the present study showed that rapamycin and everolimus induced apoptosis in PCK cholangiocytes.…”
Section: Discussionmentioning
confidence: 49%
“…Increased apoptosis has been observed in human ADPKD as well as the rodent models of PKD [3], [18][21]. Activation of caspase signaling and dysregulation of antiapoptotic bcl-2 protein have been described in PKD.…”
Section: Introductionmentioning
confidence: 99%
“…Increased epithelial proliferation and apoptosis have been proposed to contribute to cystic expansion. 5,6,56 Enhanced proliferation in Ift140-deleted collecting ducts must certainly play a role in the cystic expansion of these kidneys. Enhanced apoptosis is a characteristic in many PKD models 47 ; however, its role in cyst expansion has not been resolved.…”
Section: Discussionmentioning
confidence: 99%
“…The null- Pkd2 (E8) cell line, its maternally-derived Pkd2 heterozygous (D3) cell line, the null- Pkhd1 (M10H2) line, and its littermate-derived wildtype (W10B2) cell line were also described in our previous studies [23], [25].…”
Section: Methodsmentioning
confidence: 99%