Cystic Pancreatic Neuroendocrine Tumors

Ahrendt, Steven A.

doi:10.1016/s1091-255x(01)00020-8

Cited by 98 publications

(54 citation statements)

References 24 publications

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“…According to some authors, they might represent the effect of both necrotic [2,7,8] and/or hemorrhagic [2,9] phenomena taking place in the setting of a solid PanNET. Another recognized hypothesis is that CPanNETs are independent morphological and clinical entities within the family of NETs of the pancreas [3][4][5][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Another recognized hypothesis is that CPanNETs are independent morphological and clinical entities within the family of NETs of the pancreas [3][4][5][10][11][12]. As a matter of fact, there is scarcity of data with regard to actual differences in terms of epidemiology, biology, and long-term outcomes following surgical resection between cystic and solid pancreatic neuroendocrine tumors (SPanNETs) [5][6][7]11]. Although several surgical series report that CPanNETs can sometimes harbor malignancy [5,9,11,13], a recent metaanalysis claimed that, due to their mostly benign biology, parenchyma-sparing pancreatic resections can be advocated as the treatment of choice of CPanNETs [14].…”

Section: Introductionmentioning

confidence: 99%

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Are Cystic Pancreatic Neuroendocrine Tumors an Indolent Entity Results from a Single-Center Surgical Series

et al. 2017

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Introduction: Cystic pancreatic neuroendocrine tumors (CPanNETs) represent an uncommon variant of pancreatic neuroendocrine tumors (PanNETs). Due to their rarity, there is a lack of knowledge with regard to clinical features and postoperative outcome. Methods: The prospectively maintained surgical database of a high-volume institution was queried, and 46 resected CPanNETs were detected from 1988 to 2015. Clinical, demographic, and pathological features and survival outcomes of CPanNETs were described and matched with a population of 92 solid PanNETs (SPanNETs) for comparison. Results: CPanNETs accounted for 7.8% of the overall number of resected PanNETs (46/587). CPanNETs were mostly sporadic (n = 42, 91%) and nonfunctioning (39%). Two functioning CPanNETs were detected (4.3%), and they were 2 gastrinomas. The median tumor diameter was 30 mm (range 10-120). All tumors were well differentiated, with 38 (82.6%) G1 and 8 (17.4%) G2 tumors. Overall, no CPanNET showed a Ki-67 >5%. A correct preoperative diagnosis of a CPanNET was made in half of the cases. After a median follow-up of >70 months, the 5- and 10-year overall survival of resected CPanNETs was 93.8 and 62.5%, respectively, compared to 92.7 and 84.6% for SPanNETs (p > 0.05). The 5- and 10-year disease-free survival rates were 94.5 and 88.2% for CPanNETs and 81.8 and 78.9% for SPanNETs, respectively (p > 0.05). Conclusion: In the setting of a surgical cohort, CPanNETs are rare, nonfunctional, and well-differentiated neoplasms. After surgical resection, they share the excellent outcome of their well-differentiated solid counterparts for both survival and recurrence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are Cystic Pancreatic Neuroendocrine Tumors an Indolent Entity Results from a Single-Center Surgical Series

et al. 2017

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“…Typically, CPETs are often non-functioning and more likely to be associated with multiple endocrine neoplasia type 1 (MEN-1) [4,5,6,7,8,9,10]. Nevertheless, some insulinomas, gastrinomas and glucagonomas with cystic morphology have been described [11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Cystic Endocrine Tumors: A Different Morphological Entity Associated with a Less Aggressive Behavior

Boninsegna¹,

Partelli²,

D'Innocenzio³

et al. 2010

Neuroendocrinology

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Background: Cystic pancreatic endocrine tumors (CPETs) are rare lesions and their biological features have been scarcely investigated. Aim: To compare clinical and pathological features of resected non-functioning sporadic CPETs (NF-CPETs) with solid pancreatic endocrine tumors (SPETs) in a single-institution experience. Methods: All patients with a pathologically confirmed diagnosis of sporadic non-functioning pancreatic endocrine tumors who underwent curative resection between 1990 and 2008 were included. A comparison of demographic, clinical and pathological characteristics between CPETs and SPETs was made. Univariate and multivariable analyses were performed to identify preoperative predictors of carcinoma (non-functioning pancreatic endocrine carcinoma). Results: Twenty-one (11.5%) patients with a histological diagnosis of NF-CPET were identified. The median age was 60 years (IQR 46.5–73.5 years) and a diagnosis of carcinoma (non-functioning pancreatic endocrine carcinoma) was made in 3 (14.3%) cases. In the comparison with NF-SPETs, no differences were found in terms of gender (p = 0.75), age (p = 0.81), presenting symptoms (p = 0.43), localization of the tumors (p = 0.46) and type of resection (p = 0.31). The incidence of non-functioning pancreatic endocrine carcinoma was significantly lower in the NF-CPET versus the NF-SPET group (14.3 vs. 40.4%, p = 0.04). By univariate analysis, preoperative predictors of non-functioning pancreatic endocrine carcinoma included the presence of symptoms (OR 3.96, 95% CI 2.06–7.63) and an increase in the absolute value of radiological diameter (OR 1.05, 95% CI 1.03–1.07). A cystic morphology of the lesion turned out to be a negative predictor of carcinoma (OR 0.25, 95% CI 0.70–0.87). These results were confirmed by multivariable analysis. Conclusions: NF-CPETs have a measurable propensity to be benign. In those patients affected by small and asymptomatic NF-CPET a more conservative surgical approach or a follow-up policy could be considered.

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“…Cystic pancreatic endocrine tumors are usually benign and non-functioning. It is difficult to differentiate them from other cystic pancreatic neoplasms on imaging alone [9]. In patients with a suspected gastrinoma, the imaging emphasis should be given to the 'gastrinoma triangle'…”

Section: Wwwijhpdcommentioning

confidence: 99%

A radiologically atypical case of an ampullary neuroendocrine tumor

Yeshwante¹,

Bhuta²,

Sankhe³

et al. 2015

Int J Hepatobiliary Pancreat Dis

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Ampullary neuroendocrine tumors (ANEts) are rare tumors which show characteristic ct features. We present a case of a 42-year-old female, in which the ct features of an ampullary tumor were atypical for a neuroendocrine tumor but was confirmed on histopathology and immunohistochemistry as an NEt. the uniqueness of our case was that the lesion showed mild enhancement in the arterial phase which was persistent in the venous phase with wash out in the delayed phase

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Cystic Pancreatic Neuroendocrine Tumors

Cited by 98 publications

References 24 publications

Are Cystic Pancreatic Neuroendocrine Tumors an Indolent Entity Results from a Single-Center Surgical Series

Are Cystic Pancreatic Neuroendocrine Tumors an Indolent Entity Results from a Single-Center Surgical Series

Pancreatic Cystic Endocrine Tumors: A Different Morphological Entity Associated with a Less Aggressive Behavior

A radiologically atypical case of an ampullary neuroendocrine tumor

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