Cystic Odontogenic Tumor with Features of Calcifying Odontogenic Cyst in 3 Cats and a Dog

Abstract

This case series describes the clinical appearance, radiographic appearance and histopathologic features of 4 patients (3 cats and 1 dog) with unique cystic oral lesions that are consistent with a diagnosis of calcifying odontogenic cyst (COC). COC is a rare odontogenic lesion in humans that has not been previously reported in companion animals. Historically, COC in humans has been classified as a benign cystic neoplasm and as a non-neoplastic odontogenic cyst. Current classification favors the latter. The cases in this series also have ambiguous features regarding classification of the lesion as an odontogenic cyst versus benign neoplasia.

Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome

“…Although reverse polarity was observed in ameloblastoma and ghost cell odontogenic lesions in humans were not observed in this case, other histological features were highly supportive of the diagnosis of GCOC. Even in COC case reports in dogs, distinctive reverse polarity of the cystic epithelium was not observed, but the overall histological findings were features of COC, as in this case (14). This may be due to interspecific differences between humans and dogs.…”

“…GOGCs are extremely rare epithelial odontogenic tumors in humans ( 8 , 12 , 13 ) that have not been previously reported in companion animals. Only one study reported the occurrence of COC, in one dog and three cats ( 14 ). Compared with COC and DGCT, GCOC exhibits high-grade malignant cellular features with necrosis and histological invasion ( 9 ).…”