Cystic meningioma: A case report with a literature review

Lahkim, Mohamed; Andour, Hajar; Laamrani, Fatima Zahrae; Nouali, H. En; Fenni, J. El

doi:10.1016/j.radcr.2021.07.016

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…Histological types of meningioma were microcystic 1/5, meningothelial 2/5, mixed meningothelial-microcystic 1/5, and 1/5 was malignant. This finding is in concordance with previous case reports (19)(20)(21)(22)(23). In 3/5 patients, imaging showed inside large cysts septum-like structures.…”

Section: Discussionsupporting

confidence: 94%

Imaging and Pathological Features and Recurrence Causes of Cystic Meningioma

Long

2023

Gac Méd Caracas

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Objective: This study aims to establish preoperative imaging features, establish how they are correlating with post-operative pathological features, and discover the causes of recurrence. Results: Data on imaging procedures in the preoperative period, records of surgical operations, and reports from pathology conclusions were collected. Among 623 patients who were undergoing neurosurgery resection of intracranial meningioma, 24 cases of cystic meningioma were identified, corresponding to a world incidence of 3.8 %. The hemispheric convexity was the most frequent place of localization. The apparent diffusional coefficient was significantly lower in grade 2 and grade 3 tumors if compared to grade 1. Full resection of the cystic component was possible in 18/24 cases. Partial resection in 3/24 cases. In 2/24 cases, it was not possible to make total or partial resection, but multiple biopsies were performed from the cystic walls.

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Section: Discussionsupporting

confidence: 94%

Imaging and Pathological Features and Recurrence Causes of Cystic Meningioma

Long

2023

Gac Méd Caracas

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“…Meningiomas are commonly a solid-form tumor; far more rare are meningiomas that contain a cystic component [2]. Cystic meningiomas are described in only 2-7% of adult meningiomas [3,4]. The more common intracranial tumors with cystic components are hemangiopericytomas, high-grade gliomas, hemangioblastomas, and metastasis [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Outcomes following surgical resection of cystic intracranial meningiomas

et al. 2022

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IntroductionCystic meningiomas are rare, accounting for 2-7% of all intracranial meningiomas. Little is known regarding whether these meningiomas behave differently compared to solid meningiomas. We sought to study this relatively uncommon imaging appearance of meningioma and to evaluate its clinical signi cance. MethodsA single-institution retrospective cohort study of surgically-treated meningioma patients between 2000-2019 was conducted. Cystic meningioma was de ned as a tumor with an intratumoral or peritumoral cyst present on preoperative imaging. Demographics, preoperative imaging, histopathology characteristics, operative data, and surgical outcomes were reviewed. Imaging variables, histopathology and outcomes were reported for cystic meningiomas and compared with non-cystic meningiomas.Univariate/multivariable analyses were conducted. ResultsOf 737 total meningiomas treated surgically, 38 (5.2%) were cystic. Gross total resection (GTR) was achieved in 84.2% of cystic meningioma patients. Eighty-two percent of cystic meningiomas were WHO grade I (n = 31), 15.7% were grade II and 2.6% were grade III. Most cystic meningiomas had low Ki-67/MIB-1 proliferation index (n = 24, 63.2%). A total of 18.4% (n = 7) patients with cystic meningioma had recurrence compared to 12.2% (n = 80) of patients with non-cystic meningioma (p = 0.228). No signi cant difference in median time to recurrence was observed between cystic and non-cystic meningiomas (25.4,

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Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors

On,

Natsumeda,

Takahashi

et al. 2024

J Neurooncol

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PurposeLiquid biopsy of cyst uid in brain tumors has not been extensively studied to date. The present study was performed to see whether diagnostic genetic alterations found in brain tumor tissue DNA could also be detected in cell-free DNA (cfDNA) of cyst uid in cystic brain tumors. MethodsCyst uid was obtained from 17 patients undergoing surgery for a cystic brain tumor with con rmed genetic alterations in tumor DNA. Pathological diagnoses based on WHO 2021 classi cation and diagnostic alterations in the tumor DNA, such as IDH1 R132H and TERT promoter mutation for oligodendrogliomas, were detected by Sanger sequencing. The same alterations were analyzed by both droplet digital PCR (ddPCR) and Sanger sequencing in cyst uid cfDNA. ResultsTwenty genetic alterations were found in 17 tumor samples. All (100%) alterations were detected in cyst uid cfDNA by ddPCR.Sixteen of the 20 (80%) alterations were also detected by Sanger sequencing of cyst uid cfDNA. Variant allele frequency (VAF) in cyst uid cfDNA was comparable to that of tumor DNA (R = 0.67, Pearson's correlation). ConclusionCell-free DNA obtained from cyst uid in cystic brain tumors is a reliable alternative to tumor DNA when diagnosing brain tumors.

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Cystic meningioma: A case report with a literature review

Cited by 5 publications

References 5 publications

Imaging and Pathological Features and Recurrence Causes of Cystic Meningioma

Imaging and Pathological Features and Recurrence Causes of Cystic Meningioma

Outcomes following surgical resection of cystic intracranial meningiomas

Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors

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