“…In this mechanism, the interaction partner forms an additional -strand next to the strand C of the FLN domain and simultaneously interacts with the hydrophobic groove between the strands C and D, called the CD face (11)(12)(13)(14). It is using this mode that ligands like transmembrane receptors of the integrin family (12,15,16), the platelet von Willebrand factor receptor subunit glycoprotein Ib (GPIb) (11), and the cystic fibrosis transmembrane conductance regulator (17,18) interact with FLNa domains 17,19,21, and 23. Also, signaling protein FilGAP uses the same mechanism for interacting with FLNa domain 23 (4) and migfilin with FLNa domain 21 (13,14).…”