Cystic fibrosis: a cause of reduced birth weight?

Müller, Annekatrin; Thamm, B.; Lietz, T.; Handrïck, W; Walter, S.

doi:10.1007/s004310051065

Cited by 11 publications

(16 citation statements)

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“…We found significantly lower birth weights in both males and females with CF compared to the national average birth weights matched for gender (290.6 g and 256.3 g lower, respectively). Our findings on birth weight are similar to those of previous studies in which investigators observed significantly lower birth weights in newborns with CF compared to those without CF (Festini et al, 2005;Haeusler et al, 1994;Marcus et al, 1991;Muller et al, 1999).…”

Section: Discussionsupporting

confidence: 95%

Growth Deficiency in Cystic Fibrosis Is Observable at Birth and Predictive of Early Pulmonary Function

Darrah

Nelson

Damato

et al. 2016

Biological Research For Nursing

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Section: Discussionsupporting

confidence: 95%

Growth Deficiency in Cystic Fibrosis Is Observable at Birth and Predictive of Early Pulmonary Function

Darrah

Nelson

Damato

et al. 2016

Biological Research For Nursing

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“…6,8,9,11 Boyer's figures (though not statistically significant) point to the role of the placenta in determining the lower BW of newborns with CF. In fact, a group of mothers subjected to a special hypercaloric diet gave birth to babies with CF of a higher BW in comparison with those mothers who were not on such a diet.…”

Section: Discussionmentioning

confidence: 86%

“…It has been hypothesized that in children with CF fetal growth is altered owing to an inadequate functioning of the exocrine pancreas, 8,11 which determines reduced intrauterine nutrition and thus lower BW. Research carried out with animal models showed that the amniotic fluid supplies 10% to 14% of the nutritional needs of the fetus, 21 a quantity that would be missing in the case of PI.…”

Section: Discussionmentioning

confidence: 99%

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Gestational and Neonatal Characteristics of Children with Cystic Fibrosis: A Cohort Study

Festini

Taccetti

Repetto

et al. 2005

The Journal of Pediatrics

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“…Previous studies have shown that the mean birth weight of infants with CF is statistically lower than that of the general population [31][32][33] ; thus, maternal cigarette smoking causes a further reduction in birth weight. Active maternal smoking during gestation was not found to affect any of the 3 measures of lung function.…”

Section: Environment-phenotype Effectsmentioning

confidence: 99%

Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Collaco¹,

Vanscoy²,

Bremer³

et al. 2008

JAMA

131

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Context Disease variation can be substantial even in conditions with a single gene etiology such as cystic fibrosis (CF). Simultaneously studying the effects of genes and environment may provide insight into the causes of variation.Objective To determine whether secondhand smoke exposure is associated with lung function and other outcomes in individuals with CF, whether socioeconomic status affects the relationship between secondhand smoke exposure and lung disease severity, and whether specific gene-environment interactions influence the effect of secondhand smoke exposure on lung function. Design, Setting, and ParticipantsRetrospective assessment of lung function, stratified by environmental and genetic factors. Data were collected by the US Cystic Fibrosis Twin and Sibling Study with missing data supplemented by the Cystic Fibrosis Foundation Data Registry. All participants were diagnosed with CF, were recruited between October 2000 and October 2006, and were primarily from the United States.Main Outcome Measures Disease-specific cross-sectional and longitudinal measures of lung function. ResultsOf 812 participants with data on secondhand smoke in the home, 188 (23.2%) were exposed. Of 780 participants with data on active maternal smoking during gestation, 129 (16.5%) were exposed. Secondhand smoke exposure in the home was associated with significantly lower cross-sectional (9.8 percentile point decrease; PϽ.001) and longitudinal lung function (6.1 percentile point decrease; P=.007) compared with those not exposed. Regression analysis demonstrated that socioeconomic status did not confound the adverse effect of secondhand smoke exposure on lung function. Interaction between gene variants and secondhand smoke exposure resulted in significant percentile point decreases in lung function, namely in CFTR non-⌬F508 homozygotes (12.8 percentile point decrease; P=.001), TGF␤1−509 TT homozygotes (22.7 percentile point decrease; P=.006), and TGF␤1 codon 10 CC homozygotes (20.3 percentile point decrease; P=.005).Conclusions Any exposure to secondhand smoke adversely affects both crosssectional and longitudinal measures of lung function in individuals with CF. Variations in the gene that causes CF (CFTR) and a CF-modifier gene (TGF␤1) amplify the negative effects of secondhand smoke exposure.

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Cystic fibrosis: a cause of reduced birth weight?

Cited by 11 publications

References 0 publications

Growth Deficiency in Cystic Fibrosis Is Observable at Birth and Predictive of Early Pulmonary Function

Growth Deficiency in Cystic Fibrosis Is Observable at Birth and Predictive of Early Pulmonary Function

Gestational and Neonatal Characteristics of Children with Cystic Fibrosis: A Cohort Study

Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

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