Cystic fibrohistiocytic tumours presenting in the lung: primary or metastatic disease?

Osborn, Michael J.; Mandys,; Emma, Beddow; Ladas, George; Florio, R; Sheppard, Mary N.; Fisher, Cyril; Bell, Stephen; Travis, William D.; Nicholson, Andrew G.

doi:10.1111/j.1365-2559.2003.01717.x

Cited by 26 publications

(15 citation statements)

References 12 publications

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“…The histogenesis of cystic fibrohistiocytic tumors is unclear, but some cases may represent metastatic disease from cellular fibrous histiocytomas of the skin. In a recent series including four patients, two had a history of cutaneous fibrohistiocystic lesions in the chest wall, excised 10 and 23 years prior to developing lung tumors [130].…”

Section: Macrophage-related Focal Cystic Destruction In Rare Lung Tumorsmentioning

confidence: 99%

“…Cystic fibrohistiocytic tumor of the lung Cystic fibrohistiocytic tumors are exceedingly rare, with only eight cases (seven males, one female) having been reported as such [127][128][129][130]. The tumor is composed of multiple nodules with varying degrees of thin-walled cystic changes and multifocal proliferation of fibrohistiocytic cells in the intervening stroma.…”

Section: Macrophage-related Focal Cystic Destruction In Rare Lung Tumorsmentioning

confidence: 99%

“…All patients with follow-up (n=10) showed enlargement of the lesions but were alive with disease at an average of 5 years [127][128][129][130]. Chest radiography depicted bilateral cystic lung nodules or thin-walled cavities.…”

Section: Macrophage-related Focal Cystic Destruction In Rare Lung Tumorsmentioning

confidence: 99%

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Imaging of macrophage-related lung diseases

Marten

Hansell

2005

Eur Radiol

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Macrophage-related pulmonary diseases are a heterogeneous group of disorders characterized by macrophage accumulation, activation or dysfunction. These conditions include smoking-related interstitial lung diseases, metabolic disorders such as Niemann-Pick or Gaucher disease, and rare primary lung tumors. High-resolution computed tomography abnormalities include pulmonary ground-glass opacification secondary to infiltration by macrophages, centrilobular nodules or interlobular septal thickening reflecting peribronchiolar or septal macrophage accumulation, respectively, emphysema caused by macrophage dysfunction, and honeycombing following macrophage-related lung matrix remodeling.

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Section: Macrophage-related Focal Cystic Destruction In Rare Lung Tumorsmentioning

confidence: 99%

Section: Macrophage-related Focal Cystic Destruction In Rare Lung Tumorsmentioning

confidence: 99%

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Imaging of macrophage-related lung diseases

Marten

Hansell

2005

Eur Radiol

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“…During the past years a few examples of cellular, aneurysmal, atypical dermatofibromas as well as of dermatofibromas occurring on the face and in deep soft tissues have been reported that metastasized to lymph nodes and the lungs and even caused death of patients in some instances. 1,4,[6][7][8][9][10][11][12][13][14] Morphologically, the primary and the metastatic neoplasms showed classical features of the mentioned variants of dermatofibroma, and so far no predictive mophological features have been identified to separate classical benign dermatofibroma from rare metastasizing dermatofibroma. In this study, we investigated seven cases of malignant dermatofibroma in comparison with 10 examples of classical dermatofibroma and to 1 obvious pleomorphic dermal sarcoma not otherwise specified.…”

mentioning

confidence: 99%

Malignant dermatofibroma: clinicopathological, immunohistochemical, and molecular analysis of seven cases

et al. 2013

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Dermatofibroma (cutaneous fibrous histiocytoma) represents a common benign mesenchymal tumor, and numerous morphological variants have been described. Some variants of dermatofibroma are characterized by an increased risk of local recurrences, and there are a few reported metastasizing cases. Unfortunately, an aggressive behavior cannot be predicted reliably by morphology at the moment, and we evaluated the value of array-comparative genomic hybridization (CGH) in this setting. Seven cases of clinically aggressive dermatofibromas were identified, and pathological and molecular features were evaluated. The neoplasms occurred in four female and in three male patients (mean age was 33 years, range 2-65 years), and arose on the shoulder, buttock, temple, lateral neck, thigh, ankle, and cheek. The size of the neoplasms ranged from 1 to 9 cm (mean: 3 cm). An infiltration of the subcutis was seen in five cases. Two neoplasms were completely excised, whereas an incomplete or marginal excision was reported in the remaining cases. Local recurrences were seen in six cases (time to the first recurrence ranged from 8 months to 9 years). Metastases were noted between 3 months and 8 years after diagnosis in six patients. Two patients died of disease, and two patients are alive with disease. Histologically, the primary tumors showed features of cellular dermatofibroma (four cases), cellular/ aneurysmal dermatofibroma (one case), atypical/cellular dermatofibroma (one case), and classical dermatofibroma (one case). Mitotic figures ranged from 3 to 25 per 10 high-power fields, and focal necrosis was present in five cases. Interestingly, malignant transformation from cellular dermatofibroma to an obvious spindle cell/ pleomorphic sarcoma was seen in one primary and in one recurrent neoplasm. Five neoplasms showed chromosomal aberrations by array-CGH, suggesting that these changes may represent an additional diagnostic tool in the recognition of cases of dermatofibroma with a metastatic potential.

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“…On HRCT, it usually occurs as multiple bilateral pulmonary cysts that represent a sort of cystic changes of multiple pulmonary nodules or masses. Pneumothorax is a frequent associated feature (45,46).…”

Section: Cystic Fibrohistiocytic Tumormentioning

confidence: 99%

Differential diagnosis of cystic lung diseases

Nosenzo¹,

Ariozzi²,

Sverzellati³

2013

SOB

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SummaryA lung cyst is defined as a round parenchymal lucency or area of low attenuation with a thin wall. Although lymphangioleiomyomatosis (LAM) and Langerhans cell histiocytosis (LCH) are the most frequently encountered causes, the differential diagnosis for diseases characterised by diffuse lung cysts is broad ranging from isolated chest disorders to rare multisystem diseases. This article will illustrate and describe the spectrum of diseases associated with air cysts at high-resolution CT (HRCT), highlighting disorders in which the HRCT findings can be diagnostic.

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Cystic fibrohistiocytic tumours presenting in the lung: primary or metastatic disease?

Cited by 26 publications

References 12 publications

Imaging of macrophage-related lung diseases

Imaging of macrophage-related lung diseases

Malignant dermatofibroma: clinicopathological, immunohistochemical, and molecular analysis of seven cases

Differential diagnosis of cystic lung diseases

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