Cystic endosalpingiosis of the appendix

Pollheimer, Marion J.; Leibl, Sebastian; Pollheimer, Verena S.; Ratschek, Manfred; Langner, Cord

doi:10.1007/s00428-006-0328-9

Cited by 17 publications

(6 citation statements)

References 5 publications

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“…In the three cases reported to date, to our knowledge, the lesions, although multicystic and ranging 0.5-0.8 cm, were an incidental finding on appendectomy specimen resected during surgery for salpingitis, sigmoid stricture or diverticulosis and, devoid of inflammation [2][3][4]. The presence of disparate glandular structures in the appendix subserosa, at distance of the most intense appendicitis lesions, may suggest well-differentiated adenocarcinomatous glands, primitive or secondary, which are observed more frequently [1].…”

Section: Dear Editormentioning

confidence: 73%

“…Microscopic examination revealed in 7.38 % of the patients unsuspected findings among which endometriosis. Less frequently, remnants of salpingiosis type may also be identified in the appendix, three such cases being reported, to our knowledge, to date [2][3][4]. We have recently seen an additional case of salpingiosis of the vermiform appendix diagnosed incidentally in a previously unreported context to our knowledge, that of acute appendicitis.…”

Section: Dear Editormentioning

confidence: 81%

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Acute appendicitis revealing salpingiosis

Handra-Luca

2015

Int J Colorectal Dis

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Dear Editor:We have read with great interest the recent article on histopathological findings in 24,697 cases [1]. Microscopic examination revealed in 7.38 % of the patients unsuspected findings among which endometriosis. Less frequently, remnants of salpingiosis type may also be identified in the appendix, three such cases being reported, to our knowledge, to date [2][3][4]. We have recently seen an additional case of salpingiosis of the vermiform appendix diagnosed incidentally in a previously unreported context to our knowledge, that of acute appendicitis.The patient (49-year-old woman) presented with nausea, abdominal pain (elective right iliac fossa), frisson and vomiting. The patient's history revealed arthrosis. CT scan showed a retrocecal appendix with a thickened wall, "infiltrated" fat and peritoneal thickening. The diagnosis was that of retrocecal acute appendicitis, and appendectomy was performed. The appendix (7.2 cm in length, analysed entirely on microscopy) showed acute panappendicitis with peritonitis. Two foci of less than 1 mm in size (with a distance of 2 mm between) composed of few subserosal epithelial glands (without interspersed stroma or endometrial-type chorion) showing peg and ciliated cells were identified, suggestive of salpingiosis. The glandular cells expressed cytokeratin 7, and did not express cytokeratin 20 and calretinin. These glands were not seen on CD31stained section.Appendiceal salpingiosis is very rare. In the three cases reported to date, to our knowledge, the lesions, although multicystic and ranging 0.5-0.8 cm, were an incidental finding on appendectomy specimen resected during surgery for salpingitis, sigmoid stricture or diverticulosis and, devoid of inflammation [2][3][4]. The presence of disparate glandular structures in the appendix subserosa, at distance of the most intense appendicitis lesions, may suggest well-differentiated adenocarcinomatous glands, primitive or secondary, which are observed more frequently [1]. The lack of cell atypia and of tumoral stroma allowed to eliminate this possibility. Due to the minute size of the lesions seen in the present case, the CD31 immunohistochemical staining was non-contributive, the glandular structures being absent on this slide. The histogenesis of appendiceal salpingiosis is still matter of debate. A metaplastic origin cannot be completely ruled out although the lack of calretinin positivity. However, the hypothesis of mullerian remnant structures of tubal type remains the most plausible.In conclusion, we report here a rare case of appendiceal microscopic salpingiosis diagnosed incidentally in an appendix showing acute panappendicitis. The identification of such lesions is important to be differentiated from adenocarcinomatous glands.

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Section: Dear Editormentioning

confidence: 73%

Section: Dear Editormentioning

confidence: 81%

Acute appendicitis revealing salpingiosis

Handra-Luca

2015

Int J Colorectal Dis

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“…Hermens et al. [ 2 ] reviewed 2500 cases of women with histologically proven endosalpingiosis from 1990 to 2015 and found an age-adjusted incidence rate ratio of 44 (95% CI 35-54). They found this association was strongest with clear cell and endometroid ovarian cancer subtypes, and was independent of concurrent diagnosis of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Appendiceal endosalpingiosis: a case report of a rare finding from appendicectomy

Nayak

Karpes

Stewart

2022

Journal of Surgical Case Reports

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Endosalpingiosis is occasionally incidentally found on histopathologic examination of gynecologic or gastrointestinal specimen, most commonly in the ovary, fallopian tube, omentum and uterus. Recently an association between endosalpingiosis and, ovarian and uterine cancer has been described. Here, we describe a rare case of appendiceal endosalpingiosis mimicking appendicitis. Further prospective studies are required to elucidate the clinical significance of appendiceal endosalpingiosis, the potential association with gynecologic malignancy and implications for management.

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“…Cystic endosalpingiosis is part of müllerianosis, disorders consisting in the heterotopic presence of müllerian-derived tissue [ 1 , 2 ] in pelvic organs like the uterus [ 3 ], bladder [ 4 ], ovaries [ 5 ], parametrium [ 6 ], uterosacral mesosalpinx [ 7 ], peritoneum [ 8 ], and ureters [ 9 ] or in distant locations like the small [ 10 ] and large intestine (especially in the appendix) [ 11 ], coledochal duct [ 12 ], axillary nodes [ 13 ], mediastinum [ 14 ], umbilicus [ 15 ], vessels [ 16 ], and spine [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Florid Cystic Endosalpingiosis (Müllerianosis) in Pregnancy

Morales‐Roselló

Pamplona-Bueno

Montero-Balaguer

et al. 2016

Case Reports in Obstetrics and Gynecology

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Cystic endosalpingiosis refers to the existence of heterotopic cystic müllerian tissue resembling structures of the fallopian tubes. We report a case of florid cystic endosalpingiosis discovered in a pregnant woman during a scheduled cesarean section and review the current knowledge of this disease. A 30-year-old woman with a twin pregnancy attended the hospital day unit at term. The first twin was in a breech presentation and a cesarean section was scheduled. During the procedure the uterine fundus and part of the body were seen completely seeded with multitude of cyst-like structures resembling hydatids of Morgagni. The immunohistochemistry analysis showed a positive expression for PAX8 (Box-8), CK7, and estrogen and progesterone receptors. The lesions did not disappear after pregnancy. Cystic endosalpingiosis should be always borne in mind, even in pregnancy, when it comes to making the differential diagnosis of a pelvic or systemic multicystic mass.

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Cystic endosalpingiosis of the appendix

Cited by 17 publications

References 5 publications

Acute appendicitis revealing salpingiosis

Acute appendicitis revealing salpingiosis

Appendiceal endosalpingiosis: a case report of a rare finding from appendicectomy

Florid Cystic Endosalpingiosis (Müllerianosis) in Pregnancy

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