Cystic echinococcosis of the liver and lung treated by radiofrequency thermal ablation: An ex-vivo pilot experimental study in animal models

Lamonaca, V.; Virga, A.; Minervini, Marta Ida; Stefano, R. Di; Provenzani, A; Tagliareni, Pietro; Fleres, Giovanna; Luca, Angelo; Vizzini, Giovanni; Palazzo, U; Gridelli, Bruno

doi:10.3748/wjg.15.3232

Cited by 14 publications

(14 citation statements)

References 25 publications

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“…Less explored techniques, such as RFA, may also be further evaluated for the treatment of complex hepatic cysts. However, pre-clinical studies, such as that conducted by Lamonaca and colleagues [ 50 ], should be performed, with special focus on the treatment of complex hepatic cysts. In any case, all percutaneous techniques are invasive, with different levels of complexity, and the need for the development of alternative treatments applicable in remote, resource-poor areas remains urgent.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, no preliminary in vitro or ex vivo / in vivo animal studies had been conducted before the application of this technique in human CE. Only a later study performed in 2009 on CE cysts excised from sheep liver and lung confirmed the efficacy of the procedure on isolated cysts [ 50 ]; however, to our knowledge an in vivo experiment on E. granulosus -infected animals has never been performed.…”

Section: Non-conventional Treatmentsmentioning

confidence: 99%

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Non-surgical and non-chemical attempts to treat echinococcosis: do they work?

et al. 2014

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Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are chronic, complex and neglected diseases. Their treatment depends on a number of factors related to the lesion, setting and patient. We performed a literature review of curative or palliative non-surgical, non-chemical interventions in CE and AE. In CE, some of these techniques, like radiofrequency thermal ablation (RFA), were shelved after initial attempts, while others, such as High-Intensity Focused Ultrasound, appear promising but are still in a pre-clinical phase. In AE, RFA has never been tested, however, radiotherapy or heavy-ion therapies have been attempted in experimental models. Still, application to humans is questionable. In CE, although prospective clinical studies are still lacking, therapeutic, non-surgical drainage techniques, such as PAIR (puncture, aspiration, injection, re-aspiration) and its derivatives, are now considered a useful option in selected cases. Finally, palliative, non-surgical drainage techniques such as US- or CT-guided percutaneous biliary drainage, centro-parasitic abscesses drainage, or vascular stenting were performed successfully. Recently, endoscopic retrograde cholangiopancreatography (ERCP)-associated techniques have become increasingly used to manage biliary fistulas in CE and biliary obstructions in AE. Development of pre-clinical animal models would allow testing for AE techniques developed for other indications, e.g. cancer. Prospective trials are required to determine the best use of PAIR, and associated procedures, and the indications and techniques of palliative drainage.

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Section: Discussionmentioning

confidence: 99%

Section: Non-conventional Treatmentsmentioning

confidence: 99%

Non-surgical and non-chemical attempts to treat echinococcosis: do they work?

et al. 2014

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“…Postoperative complications include biliary leakage, fistulas, and liver abscess formation. 13 Lamonaca et al 14 concluded that in RFA treatment, bile duct and bronchial wall necrosis and persistence of endocyst attached to pericystium may be associated with decreased posttreatment fistula occurrence and consequent overlapping complications that are common after surgery, percutaneous aspiration, injection, and reaspiration. 14 Furthermore, biliocystic communication and cystocutaneous fistula with bile leakage after surgery can be treated by ablation of cysts with fistulas.…”

Section: Discussionmentioning

confidence: 99%

Pericyst Radiofrequency Ablation Treatment for Hepatic Alveolar Echinococcosis

Lederer¹,

Wiedermann²,

Bale³

2012

Infectious Diseases in Clinical Practice

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Cystic disease of the liver caused by Echinococcus multilocularis remains a serious health concern in many countries. Curative treatment is often restricted to centers with facilities for liver surgery. However, surgical removal of cysts carries the risk of intraoperative or postoperative complications, including the probability of spreading contents, anaphylactic reaction, hemorrhage, infection, abscess formation, and biliary fistula. Pericyst radiofrequency ablation, without penetrating the exocyst, could turn out to be a safe and liver tissueYsparing treatment option. Furthermore, a hospital stay of 2 to 3 days means a reduction in overall costs for hospitalization and treatment.

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“…But now there are lots of problems existed in ablation equipment temperature and power control, which directly affect the melting effect. So this paper is based on this target to design a more effective radiofrequency ablation temperature and power control system, measuring temperature ablation area center and edge at the same time [5]. In terms of software algorithm design of the control system, much of them are based on fuzzy control algorithm [6,7], neural network algorithm and genetic algorithm, and the PID algorithm design [8][9][10][11].…”

Section: Radiofrequency Ablation System and Temperature Control Modulementioning

confidence: 99%

Radiofrequency Signal in the Radiofrequency Ablation System

Wang¹,

Nan²,

Tian³

et al. 2016

Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

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Radiofrequency ablation technique is one of the tumor hyperthermia methods and has been widely used in clinical treatment because of its small traumatic, better curative effect and others advantages. Recently, the common automatic control of radiofrequency ablation system is temperature control model that only used to control electrode tip temperature by controlling center of the output power to prevent cooking, rather than monitoring temperature of tumor edge, leading to the result is not accurate. So for the purpose of being ablated completely without damaging the normal tissue, this paper puts forward with double temperature controlling system to monitor the electrode tip and the tumor edge temperature at the same time, and control the output power according to the change of the temperature, in order to achieve the purpose of accurate ablation. Now The design of radiofrequency ablation signal have been finished, including the final output signal peak-to-peak voltage of 140V, current 0.3A, total power adjusted in 2W to 18W.

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Cystic echinococcosis of the liver and lung treated by radiofrequency thermal ablation: An ex-vivo pilot experimental study in animal models

Cited by 14 publications

References 25 publications

Non-surgical and non-chemical attempts to treat echinococcosis: do they work?

Non-surgical and non-chemical attempts to treat echinococcosis: do they work?

Pericyst Radiofrequency Ablation Treatment for Hepatic Alveolar Echinococcosis

Radiofrequency Signal in the Radiofrequency Ablation System

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