Cystic echinococcosis in children — The seventeen-year experience of two large medical centers in Serbia

Djuričić, Slaviša; Grebeldinger, Slobodan; Kafka, Dejan I.; Djan, I.; Vukadin, Miroslav; Vasiljević, Zorica

doi:10.1016/j.parint.2010.02.011

Cited by 48 publications

(48 citation statements)

References 26 publications

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“…Their result is similar to that in our study insofar as the lung was the most commonly involved organ (49.7%) in our patients, which is concordant with the results of some other similar studies on children (3,4,11). Nevertheless, there are some other studies that show a larger number of hydatid cysts in the liver than in the lung among children (8,18,19). Various genotypes of Echinococcus granulosus isolated form different animal sources can be responsible for the heterogeneity of the results and may contribute to a clinically or histologi-cally heterogeneous disease (20,21).…”

Section: Discussionsupporting

confidence: 93%

“…Various genotypes of Echinococcus granulosus isolated form different animal sources can be responsible for the heterogeneity of the results and may contribute to a clinically or histologi-cally heterogeneous disease (20,21). Combined liver and lung involvement was detected in 15.5% of our cases, with the percentage of other combinations of the infected sites being 4.7%, which is in line with some other surveys performed in children (6% -16%) (18,22,23). It is vitally important that the combined organ involvement not be missed because the maltreatment of the hydatid cyst can result in recurrence in patients.…”

Section: Discussionsupporting

confidence: 89%

“…These results are slightly higher than those in the literature on the prevalence of hydatid cysts in the spleen (0.9% -8%) and kidney (18,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Discussioncontrasting

confidence: 58%

“…The female-to-male ratio was 1.6:1 (8). Djuricic et al (18) reported the mean age of 10.1 ± 3.8 years in their study, which included 149 patients under 18 years of age. The authors found no significant difference in terms of the gender of their patients.…”

Section: Discussionmentioning

confidence: 99%

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Overview of Hydatid Disease in Iranian Children

Fahimzad

Karimi

Tabatabaei

et al. 2015

Arch Pediatr Infect Dis

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Background: Hydatid disease (HD) is still an important health hazard in the world. This disease is a parasitic infestation endemic in many sheep-and cattle-raising areas such as Iran. Objectives: This study aimed to review the clinical manifestations, laboratory aspects, imaging findings, and management of HD. Patients and Methods: Data were collected from the medical records of patients diagnosed with HD in eight referral hospitals in different provinces of Iran from 2001 to 2014. Results: Overall, 161 children at a mean age of 9.25 ± 3.37 years (age range = 1 -15 years old) hospitalized with a definite diagnosis of the hydatid cyst between 2001 and 2014 were studied. The male-to-female ratio was 1.6:1. The most commonly involved organ was the lung (67.1%), followed by the liver (44.1%) and a combined liver and lung involvement was found in 15.5% of the patients. The cysts were found more frequently in the right lobe of the liver and lung than in the left lobe. The most frequent complaints were fever (35.4%) and abdominal pain (31.7%), and the most frequent sign was an abdominal mass in the liver involvement and cough in the lung involvement. There was a high eosinophil count (> 500/micL) in 41% of our cases. A high erythrocyte sedimentation rate (> 30) or positive C-reactive protein (based on the qualitative method) was found in 18.6% of the patients and leukocytosis > 15000/micL in 29.2% of the children. Ultrasonography was the main imaging test, with an accuracy rate of 96%, and chest X-ray was helpful in 88.6% of the cases. Surgery was performed in 89% of the patients, and selective patients underwent percutaneous aspiration-injection-reaspiration drainage or medical treatment. Conclusions: The lung was the most commonly involved organ in the children recruited in the present study. Given the high probability of multiple organ involvement, we recommend that patients with HD be assessed via ultrasonography and chest X-ray. In endemic regions, unexplained eosinophilia should be considered as a parasitic disease like HD and its complications.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

“…These results are slightly higher than those in the literature on the prevalence of hydatid cysts in the spleen (0.9% -8%) and kidney (18,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Overview of Hydatid Disease in Iranian Children

Fahimzad

Karimi

Tabatabaei

et al. 2015

Arch Pediatr Infect Dis

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“…Although the diagnosis of HD is usually based on patient history and clinical findings, neither method is specific enough to be diagnostic [1,5]. In spite of the diagnosis of HD being primarily based on imagery and serological tests, the differential diagnosis between HD and cystic lesions may not be easy [1].…”

Section: Discussionmentioning

confidence: 99%

A Cystic Mass does not Always Mean Hydatid Cyst in Endemic Areas

Yildiz

Oral

Akın

et al. 2014

EAJM

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Within the medical community, there is a tendency to describe all cystic lesions in the liver and lungs as Hydatid disease (HD) in areas with HD endemics. This approach may sometimes cause a misdiagnosis. We have three cases with children aged between seven, seven and ten year old, all of whom had been diagnosed, via radiologic imaging, with HD cysts and started on treatment without confirmation. The true diagnoses of these cases were undifferentiated embryonal sarcoma (UES) in two and oesophageal duplication in one case, respectively. The indirect haemagglutination assays (IHA) were obtained in two of them. Although their results were negative, albendazole treatment was started in all cases. Confirmatory tests should be run in dubious cases. An IHA test can aid the diagnosis, although its effectiveness is limited. The possibility of false positive and negative results always exists, especially in lung cysts. A percutanous biopsy is strongly advised for differential diagnosis.

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