Cystic dysplasia of the rete testis

Kajo, Karol; Matoŝka, J; Javorka, K; Macháleková, Katarína; Tomaskin, R.; Kliment, K

doi:10.1111/j.1600-0463.2005.apm_342.x

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…The cysts can be very large and involve the entire testis, pushing the seminiferous tubules to the periphery. CDRT results from a congenital blind-ended rete testis and is associated with ipsilateral kidney agenesis (Leissring & Oppenheimer 1973, Nistal et al 1984, Glantz et al 1995, Loo & Yung 1995, Simoneaux et al 1995, Zaragoza et al 1996, Bonnet et al 1997, Wojcik et al 1997, Ngai et al 1998, Robson et al 1998, Toffulutti et al 1999, Camassei et al 2002, Kajo et al 2005). CDRT is very similar to the Lfng -deficient phenotype we detected, implicating Notch signaling pathway genes in the development of this defect.…”

Section: Discussionmentioning

confidence: 99%

A deficiency of lunatic fringe is associated with cystic dilation of the rete testis

et al. 2009

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Lunatic fringe belongs to a family of β1–3 N-acetyltransferases that modulate the affinity of the Notch receptors for their ligands through the elongation of O-fucose moieties on their extracellular domain. A role for Notch signaling in vertebrate fertility has been predicted by the intricate expression of the Notch receptors and their ligands in the oocyte and granulosa cells of the ovary and the spermatozoa and Sertoli cells of the testis. It has been demonstrated that disruption of Notch signaling by inactivation of lunatic fringe led to infertility associated with pleiotropic defects in follicle development and meiotic maturation of oocytes. Lunatic fringe null males were found to be subfertile. Here, we report that gene expression data demonstrate that fringe and Notch signaling genes are expressed in the developing testis and the intratesticular ductal tract, predicting roles for this pathway during embryonic gonadogenesis and spermatogenesis. Spermatogenesis was not impaired in the majority of the lunatic fringe null males; however, spermatozoa were unilaterally absent in the epididymis of many mice. Histological and immunohistochemical analysis of these testes revealed the development of unilateral cystic dilation of the rete testis. Tracer dye experiments confirm a block in the connection between the rete testis and the efferent ducts. Further, the dye studies demonstrated that many lunatic fringe mutant males had partial blocks of the connection between the rete testis and the efferent ducts bilaterally.

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Section: Discussionmentioning

confidence: 99%

A deficiency of lunatic fringe is associated with cystic dilation of the rete testis

et al. 2009

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“…This extremely rare cause of scrotal swelling may appear on physical examination as a painless transilluminating testicular mass [8]. Pain is very rarely seen, as the scrotum enlarges [6, 7].…”

Section: Discussionmentioning

confidence: 99%

A Case of Cystic Dysplasia of the Rete Testis in a 17-Months-Old Boy

Poupalou

Spyridis

Vakaki

et al. 2011

Case Reports in Medicine

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Cystic dysplasia of the testis (CDT) is a benign, congenital malformation of the testis and a rare cause of painless scrotal swelling in children, mimicking testicular cancer. It is commonly unilateral, often associated with ipsilateral wolffian duct and ureteral abnormalities. Cystic dysplasia of the rete testis (CDT) represents a diagnostic challenge made easier if age, precise localisation, typical ultrasonographic features, the presence or absence of associated genitourinary malformations, as well as tumor markers are considered. The definite treatment of such a benign lesion is testis-sparing surgery, however in most cases watch and wait strategy can be recommended. We present a case of cystic dysplasia of the testis in a 17-month-old boy with right multicystic dysplastic kidney, epididymal cyst, history of vesicoureteral reflux (VUR), as well as of solitary umbilical artery. We performed epididymidal cyst enucleation and right testicular biopsy.

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“…This is dysplastic cystic transformation of an excessively developed rete testis. As a result, the seminiferous tubules might suffer variable degrees of dilatation and atrophy, features that become more evident in postpubertal ages [3][4][5][6][7][8][9].…”

Section: Cystic Dysplasia Of the Rete Testismentioning

confidence: 99%

Perspectives in Pediatric Pathology, Chapter 11. Testicular Pathology of Hamartomatous Origin

et al. 2016

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The term hamartoma was coined by Albrecht in 1904 from the Greek mart-ánv, to go wrong [1]. Hamartoma is currently used to name nonneoplastic lesions composed of disorganized tissue indigenous to the site where it is found. In the testis, this refers to abnormal/excessive development of structures that usually form part of the gonadal parenchyma, epididymis, or spermatic cord. We include the following as hamartomatous lesions of the testis and sperm excretory ducts: cystic dysplasia of the rete testis, rete testis hamartomas, fetal gonadoblastoid testicular dysplasia (FGTD), Sertoli cell nodules, tubular hamartomas, congenital testicular and epididymal lymphangiectasis, and smooth muscle hyperplasia of paratesticular structures. These hamartomas are always benign, but their importance resides in their association with specific disorders, or as markers of complex syndromes.

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Cystic dysplasia of the rete testis

Cited by 12 publications

References 24 publications

A deficiency of lunatic fringe is associated with cystic dilation of the rete testis

A deficiency of lunatic fringe is associated with cystic dilation of the rete testis

A Case of Cystic Dysplasia of the Rete Testis in a 17-Months-Old Boy

Perspectives in Pediatric Pathology, Chapter 11. Testicular Pathology of Hamartomatous Origin

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