Cystic Cavernoma of Fourth Ventricle in Pediatric Patient

Yeo, Jared Jue Ying; Chang, Kenneth Tou-En; Ng, Lee Ping; Seow, Wan Tew; Low, David C.Y.; Low, Sharon Yin Yee

doi:10.1016/j.wneu.2017.12.106

Cited by 2 publications

(2 citation statements)

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“…Keywords used for the search were “cystic cavernomas,” “cystic cavernous malformations,” and “cystic cavernous angiomas.” All articles in English literature where the emphasis was placed on the reporting of intracranial cCCMs (the imaging appearance showed a significant cystic component to the lesion) and their typical features were selected for analysis; and a total of 42 publications reporting 52 cases of cCCMs were identified and analyzed ( Table 1 ). 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Epidemiological data, namely age, sex, and family history; clinical symptoms at presentation; imaging features; extent of surgical resection; and outcome were analyzed descriptively. Radiation-induced cCCMs were excluded.…”

Section: Methodsmentioning

confidence: 99%

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Cystic Cerebral Cavernous Malformations: Report of Five Cases and a Review of Literature

et al. 2023

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Introduction Cerebral cavernous malformations (CCMs) account for about 5 to 13% of intracranial vascular malformations. Cystic cerebral cavernous malformations (cCCMs) are a rare morphological variant and can cause diagnostic and therapeutic dilemmas. We describe our five such cases and review the existing literature on this entity. Methods A search of the PubMed database for cCCMs was done, and all articles in English emphasizing the reporting of cCCMs were selected. A total of 42 publications describing 52 cases of cCCMs were selected for analysis. Epidemiological data, clinical presentation, imaging features, the extent of resection, and outcome were analyzed. Radiation-induced cCCMs were excluded. We have also described five of our cases of cCCMs and reported our experience. Results The median age at presentation was 29.5 years. Twenty-nine patients had supratentorial lesions, 21 had infratentorial lesions, and 2 had lesions in both compartments. Among our four patients, three had infratentorial lesions, whereas one had a supratentorial lesion. Multiple lesions were seen in four patients. A majority (39) had symptoms of mass effect (75%), and 34 (65.38%) had raised intracranial pressure (ICP), whereas only 11 (21.15%) had seizures. Among our four operated patients, all of them had symptoms of mass effect, and two of them also had features of raised ICP. The extent of resection was gross total in 36 (69.23%), subtotal in 2 (3.85%), and not reported in 14 (26.93%). All four of our operated patients underwent gross total resection, but two of them underwent a second surgery. Of the 48 patients in whom the surgical outcome was reported, 38 improved (73.08%). One showed a transient worsening followed by improvement, one developed a worsening of the pre-existing focal neurological deficit (FND), two developed a new FND, and 5 had no improvement in their FNDs. Death occurred in one patient. All four of our operated patients improved after surgery, although three of them showed a transient worsening of FNDs. One patient is under observation. Conclusion cCCMs are rare morphological variants and can cause considerable diagnostic and therapeutic dilemmas. They should be considered in the differential diagnosis of any atypical cystic intracranial mass lesion. Complete excision is curative, and the outcome is generally favorable; although transient deficits may be seen.

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Section: Methodsmentioning

confidence: 99%

“… 9 10 The traditional classification systems (like Zabramski's) do not describe a cystic variety separately. 5 Cystic CCMs (cCCMs) are rare 4 9 11 12 13 and their prevalence has not been reported in literature. They can cause considerable diagnostic and management dilemmas.…”

Section: Introductionmentioning

confidence: 99%