Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes

Levy, Bruce D.; Abdulnour, Raja-Elie E.; Tavares, Alexander H.; Brüggemann, Thayse Regina; Norris, Paul C.; Bai, Yan; Ai, Xingbin; Serhan, Charles N.

doi:10.1016/j.jaci.2019.09.028

Cited by 39 publications

(31 citation statements)

References 32 publications

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“…Lastly, the recently described SPMs Maresin Conjugates in Tissue Regeneration (MCTRs) were shown to counter regulate airway inflammation and hyperreactivity competing with cysteinyl leukotrienes for the cysteinyl leukotriene receptor 1 (CysLT1) in preclinical studies ( Levy et al, 2020 ). Proof of concept studies in asthma patients will uncover the potential benefits of inducing resolution during this chronic lung inflammatory disease.…”

Section: Asthmamentioning

confidence: 99%

Novel Immunomodulatory Therapies for Respiratory Pathologies

Tavares

Galvão

Ferrero

2022

Comprehensive Pharmacology

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Section: Asthmamentioning

confidence: 99%

Novel Immunomodulatory Therapies for Respiratory Pathologies

Tavares

Galvão

Ferrero

2022

Comprehensive Pharmacology

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“…Although our study has several strengths, including the sample size (n = 10) which is within the accepted group size based on recent peer literature of animal-based metabolomics studies (59)(60)(61)(62), there are a number of limitations that are important to mention. First, drop-out was observed in the 7-day sham and 7-day AKI groups.…”

Section: Limitationsmentioning

confidence: 99%

Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion

Ambruso

Gil

Fox

et al. 2021

American Journal of Physiology-Lung Cellular and Molecular Phys

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Acute kidney injury (AKI) is a complex disease associated with increased mortality that may be due to deleterious distant organ effects. AKI associated with respiratory complications, in particular, has a poor outcome. In murine models, AKI is characterized by increased circulating cytokines, lung chemokine upregulation, and neutrophilic infiltration, similar to other causes of indirect acute lung injury (ALI)(e.g., sepsis). Many causes of lung inflammation are associated with a lung metabolic profile characterized by increased oxidative stress, a shift towards the use of other forms of energy production, and/or a depleted energy state. To our knowledge, there are no studies that have evaluated pulmonary energy production and metabolism after AKI. We hypothesized that based on the parallels between inflammatory acute lung injury and AKI-mediated lung injury, a similar metabolic profile would be observed. Lung metabolomics and ATP levels were assessed 4 hours, 24 hours, and 7 days after ischemic AKI in mice. Numerous novel findings regarding the effect of AKI on the lung were observed including 1) increased oxidative stress, 2) a shift toward alternate methods of energy production, and 3) depleted levels of ATP. The findings in this report bring to light novel characteristics of AKI-mediated lung injury and provide new leads into the mechanisms by which AKI in patients predisposes to pulmonary complications.

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“…Furthermore, an increasing number of miRNAs ( Figure 1 ) are confirmed to directly regulate leukotriene levels by targeting proteins associated with AA metabolism ( 24 , 54 , 55 ). The majority of miRNAs mentioned above were involved in pathways related to the immune and inflammatory responses such as macrophage polarization states ( 56 – 58 ), which is closely associated with the balance between leukotriene synthesis and regression and the following severe airway inflammation ( 59 – 61 ).…”

Section: Mirnas Expression Profile Changed In Rsv Infectionmentioning

confidence: 99%

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

Fan

et al. 2021

Front. Pediatr.

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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate posttranscription by binding to 3′-untranslated regions of target mRNAs. Recent functional studies have elucidated mechanisms that miRNAs regulate leukotriene synthesis by perturbing arachidonic acid metabolism. Both microarrays and high-throughput sequencing revealed distinct differential expression of miRNAs in children with respiratory syncytial virus (RSV) infection compared with healthy controls. Abnormal miRNA expression may contribute to higher leukotriene levels, which is associated with airway hyperreactivity. Targeting miRNAs may benefit to restore the homeostasis of inflammatory reaction and provide new strategies to alleviate airway hyperreactivity induced by RSV. In this article, we provide an overview of the current knowledge about miRNAs modulating leukotrienes through regulation of arachidonic acid metabolism with a special focus on miRNAs aberrantly expressed in children with RSV infection.

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Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes

Abstract: MCTRs promote resolution of allergic lung inflammation by decreasing:-Eosinophils -Airway hyperresponsiveness -Serum immunoglobulin -Lung edema Inflammation Resolution LTD 4CysLT1 MCTR, maresin conjugate in tissue regeneration, LTD 4 , leukotriene D 4 ; Ova, ovalbumin; HDM, house dust mite

Cited by 39 publications

References 32 publications

Novel Immunomodulatory Therapies for Respiratory Pathologies

Novel Immunomodulatory Therapies for Respiratory Pathologies

Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

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