Cysteinyl Leukotrienes Promote Human Airway Smooth Muscle Migration

Parameswaran, Krishnan; Cox, Gerard; Radford, Katherine; Janssen, Luke J.; Sehmi, Roma; O'Byrne, Paul M.

doi:10.1164/rccm.200204-291oc

Cited by 112 publications

(112 citation statements)

References 35 publications

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“…CYSLTR1 encodes the G-proteincoupled receptor CysLT 1 . Cys-LTs are biologically active lipid mediators, which can promote human airway smooth muscle contraction, proliferation and migration [29]. Cys-LTs have also been reported to be involved in the generation of type-2 T-helper cell cytokines and expression of some mediators involved in the process of airway inflammation and remodelling, such as TNF-a, endothelin 1 [30], reactive oxygen intermediate [31], histamine receptor [32] and IL-11 [33].…”

Section: Discussionmentioning

confidence: 99%

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma

Hong¹,

Zhou²,

Tsai³

et al. 2009

European Respiratory Journal

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Although it has been recognised that genetics plays an important role in the development of asthma, important causal loci remain to be identified. The aim of the present study was to examine the association of known and novel candidate genes with asthma.Two independent samples, including 170 asthmatic cases and 347 controls in the initial sample, and 202 asthmatic cases and 332 controls in the confirmation sample, were recruited from the same region of China. Functional single nucleotide polymorphisms (SNPs; n5129) from 105 genes were genotyped using MassARRAY technology, and 119 SNPs were used for the subsequent analysis.In the initial sample, three SNPs, rs320995 in the cysteinyl leukotriene receptor 1 gene, rs1047266 in the tumour necrosis factor receptor superfamily, member 10b, gene and rs40401 in the interleukin-3 gene, were associated with risk of asthma. Notably, under the recessive genetic model, subjects without the thymidine allele in SNP rs320995 had a 3.1 times higher risk of asthma, which remained significant after accounting for multiple testing. This association was replicated in the confirmation sample and validated by meta-analysis. Further, sex-specific analysis was performed, but no sex difference was found.The present study provided coherent evidence that cysteinyl leukotriene receptor 1 gene variation is associated with risk of asthma.

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Section: Discussionmentioning

confidence: 99%

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma

Hong¹,

Zhou²,

Tsai³

et al. 2009

European Respiratory Journal

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“…It revealed that genes related to extracellular matrix, transcription, and cellular stress responses were deregulated in fibroids. Collagen has been shown to directly stimulate smooth muscle cell growth (Herz et al, 2003) and regulate cell migration (Parameswaran et al, 2004). Increased expression of collagens and other extracellular matrix proteins could thus have an important role in fibroid growth.…”

Section: Discussionmentioning

confidence: 99%

7q deletion mapping and expression profiling in uterine fibroids

et al. 2005

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Uterine fibroids are some of the most common tumours of females, but relatively little is known about their molecular basis. Several studies have suggested that deletions on chromosome 7q could have a role in fibroid formation. We analysed 165 sporadic uterine fibroids to define a small 3.2 megabase (Mb) commonly deleted region on 7q22.3-q31.1, flanked by clones AC005070 and AC007567. We also used oligonucleotide microarrays to compare the expression profiles of 10 samples of normal myometrium and 15 fibroids, nine of which displayed 7q-deletions. Activating transcription factor 3, patched homolog (Drosophila), homeo box A5, death-associated protein kinase 1, and retinoic acid receptor responder 3 were downregulated, and excision repair crosscomplementing 3, transcription factor AP-2 gamma and protein kinase C beta 1 were upregulated in fibroids. New pathways were discovered related to fibroid formation. The presence or absence of 7q-deletions did not dramatically affect the global expression pattern of the tumours; changes, however, were observed in genes related to vesicular transport and nucleic acid binding.

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“…Migration is required for each of these alternative mechanisms for smooth muscle hyperplasia. Migration of ASM can be induced by plateletderived growth factor [116,117], enhanced by cys-leukotrienes [118] modulated by b 2 -adrenoceptor agonists and glucocorticoids [119], with the latter agents losing activity when cells are seeded onto a matrix containing monomeric type-1 collagen [120,121].…”

Section: Asm Growth Responsesmentioning

confidence: 99%

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

An¹,

Bai²,

Bates³

et al. 2007

European Respiratory Journal

341

298

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Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma.As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of the noncontractile components of the airway wall, or a change in the interdependence of the airway wall with the surrounding lung parenchyma. All these potential changes could result from acute or chronic airway inflammation and associated tissue repair and remodelling.Anti-inflammatory therapy, however, does not ''cure'' asthma, and airway hyperresponsiveness can persist in asthmatics, even in the absence of airway inflammation. This is perhaps because the therapy does not directly address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM.In the present study, a central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored.

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Cysteinyl Leukotrienes Promote Human Airway Smooth Muscle Migration

Cited by 112 publications

References 35 publications

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma

7q deletion mapping and expression profiling in uterine fibroids

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

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