Cysteinyl Leukotrienes Enhance the Degranulation of Bone Marrow-Derived Mast Cells through the Autocrine Mechanism

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

“…MCs are a primary source of cysteinyl LTs (Austen, 2005) after allergic or nonallergic stimulation and, accordingly to their classification as autacoids, CysLTRs are widely expressed in these cells (Mellor et al, 2001;Sjöström et al, 2002) and are responsible for their proliferation and activation (Jiang et al, 2006Kaneko et al, 2009). In agreement with this finding, montelukast has been found to significantly reduce the number of MCs in the inflamed paws of mice with collagen-induced arthritis (Shiota et al, 2006).…”

Mast cells and eosinophils: the two key effector cells in allergic inflammation

“…For example, mast cells secrete PGD 2 , LTB 4 , LTC 4 and LTE 4 which may act as a potent chemoattractant for eosinophils or neutrophils, induce the recruitment of these cells to the bronchial mucosa of human asthmatic patients, influence eosinophil adhesion and induce IL-8 secretion from eosinophils [4,19,[58][59][60][61]. Eosinophils also represent a major source of LTC 4 , LTD 4 and LTE 4 [62][63][64] which are capable of promoting mast cells degranulation [65]. Since both cells express receptors for these metabolites [57,66], this implies autocrine signaling functions as well.…”

Leukotriene Antagonist Drugs as Treatment of Allergic Conjunctivitis and Comorbidities in Children

“…Moreover, conjunctival and corneal epithelial cells and fibroblasts may contribute to mounting the allergic inflammation by expressing and producing cytokines, chemokines, adhesion molecules and growth factors that maintain local inflammation and lead to tissue remodelling (Leonardi et al, 2006). Montelukast was reported to significantly attenuate LT-induced degranulation of bone marrow derived mast cells (Kaneko et al, 2009). The drug was also found to inhibit the expression of vascular endothelial growth factor and its receptors in lung tissue of experimentally induced asthma in rats.…”