Cystectomy for Carcinoma of the Bilharzial Bladder: 138 cases 5 Years Later

Abstract

Our experience is outlined with 138 cases of bilharzial bladder cancer treated by radical cystectomy and followed for 5 years. The operative mortality was 13.7%. The 5-year survival rate was 32.6%. Analysis of survival figures revealed that the tumour grade was the most important prognostic factor. Most treatment failures were due to local recurrence which developed early after treatment. It was concluded that improvement in survival might be obtained by some form of pre-operative irradiation augmented by the use of a hypoxic cell sensitiser.

Squamous Cell Carcinoma of the Urinary Bladder

“…7,37 Regular follow-up was possible in 13 patients after definitive surgical treatment. Six patients were well and cancerfree, seven cases died from cancer, and seven were lost to follow-up.…”

Squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management

“…10,54,61,62 In spite of the rare incidence of microscopically positive resection margins (8.8% 37 ), local recurrence following radical cystectomy accounts for approximately 75% of failures of this treatment. 14,63 Most recurrences are clinically detectable within the first year following surgery. 64 The pathological tumor stage, tumor grade, and nodal status are the main risk factors that determine local recurrence.…”

A model to predict the outcome of the bilharzial bladder cancer patient after radical cystectomy

“…Most prognostic studies of bladder cancer have dealt with survival (Osborn et al, 1982;England et al, 1981;Kishi et al, 1981;Cifuentes Delatte et al, 1982) and a minority with recurrence or metastasis (Dalesio et al, 1983;Pocock et al, 1982). Moreover these prognostic studies have generally been concerned with 'Western' bladder cancer (Osborn et al, 1982;Dalesio et al, 1983;Pocock et al, 1982) while few studies have dealt with bilharzial bladder cancer (Ghoneim et al, 1972(Ghoneim et al, ,1976(Ghoneim et al, ,1979Sherif and Ibrahim, 1983 England et al, 1981;Ghoneim et al, 1972Ghoneim et al, ,1976Smith & Whitmore, 1981;Varkarakis et al, 1975;Ballanger & Ballanger, 1982). Our study did not prove the prognostic value of multiplicity or histopathology of the tumour; some authors concur with this conclusion while others dissent (Ghoneim et al, 1979;Kishi et al, 1981).…”

“…Moreover these prognostic studies have generally been concerned with 'Western' bladder cancer (Osborn et al, 1982;Dalesio et al, 1983;Pocock et al, 1982) while few studies have dealt with bilharzial bladder cancer (Ghoneim et al, 1972(Ghoneim et al, ,1976(Ghoneim et al, ,1979Sherif and Ibrahim, 1983 England et al, 1981;Ghoneim et al, 1972Ghoneim et al, ,1976Smith & Whitmore, 1981;Varkarakis et al, 1975;Ballanger & Ballanger, 1982). Our study did not prove the prognostic value of multiplicity or histopathology of the tumour; some authors concur with this conclusion while others dissent (Ghoneim et al, 1979;Kishi et al, 1981). Presence of ova of schistosoma haematobium in the tumour did not appear to be prognostic and this confirms the previous work of the present authors (Sherif & Ibrahim, 1983 Prediction of outcome by utilizing our model is a point of considerable clinical importance.…”