The
understanding of interactions between organic chromophores
and biocompatible luminescent noble metal nanoclusters (NCs) leading
to an energy transfer process that has applications in light-harvesting
materials is still in its nascent stage. This work describes a photoluminescent
supramolecular assembly, made in two stages, employing an energy transfer
process between silver (Ag) NCs as the donor and a host–guest
system as the acceptor that can find potential applications in diverse
fields. Initially, we explored the host–guest chemistry between
a cationic guest ethidium bromide and cucurbit[8]uril host to modulate
the fluorescence property of the acceptor. The host–guest interactions
were characterized by using UV–vis absorption, steady-state
and time-resolved spectroscopy, molecular docking, proton 1H nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry,
and isothermal calorimetry studies. Next, we prepared a series of
blue-emitting AgNCs using different templates such as proteins and
peptides. We have found that these AgNCs can be employed as a donor
in the energy transfer process upon mixing with the above acceptor
for emission color tuning. Our in-depth studies also revealed that
surface ligands could play a key role in modulating the energy transfer
efficiency. Overall, by employing a noncovalent strategy, we have
tried to develop Förster resonance energy transfer (FRET) pairs using blue-emitting NCs and a host–guest complex
that could find potential applications in constructing advanced sustainable
light-harvesting, white light-emitting, and anti-counterfeiting materials.