Cysteamine administration in lambs grazing on mountain pastures: Effects on the body weight, antioxidant capacity, thyroid hormones and growth hormone secretion

Abstract

This study aimed to evaluate the effects of intravenous injection of cysteamine (CS) on body weight (BW), growth hormone (GH), thyroid hormones (TH) secretion, and antioxidant status of growing lambs grazing on mountain pastures. Fifteen lambs (3-4 months of age) were randomly allocated into three experimental groups which received different dosages of CS: 0, 20, and 50 mg/kg BW −1 . The CS was injected on the 1st, 10th , and 20th days of the experiment to the lambs through the jugular vein.Assessment of plasma concentration of GH and TH hormones was carried out at days 0 (a day before the start of CS injections), 15, and 30 of the experiment. The antioxidant enzymes were measured at the end of the experiment. Lambs were weighed at days 0, 10, 20, and 30 of the experiment. The results showed that treatment and time affected the BW, GH, triiodothyronine (T 3 ), and tetraiodothyronine (T 4 ) secretion. The intravenous injection of CS increased the BW of growing lambs (p < 0.01) and increased the plasma concentration of GH, T3, and T4 (p < 0.01). The treatment also enhanced glutathione peroxidase (GSH-Px; p < 0.05) and reduced malondialdehyde concentrations (MDA; p < 0.01). Total antioxidant capacity (T-AOC) level reduced in CS-1 treatment compared to GC and CS-2 treatments (p < 0.01). The levels of superoxide dismutase (SOD) and catalase (CAT) were not affected by CS. In conclusion, intravenous injection of CS improved BW, GH, and TH concentrations and antioxidant capacity in growing lambs grazing on mountain pastures.

Cysteamine-supplemented diet for cashmere goats: A potential strategy to inhibit rumen biohydrogenation and enhance plasma antioxidant capacity

“…We found that the plasma levels of GH, IGF-1, and T-SH were significantly increased, while the levels of SS were significantly decreased in the CS treatment groups. This is consistent with the results observed for red tilapia ( 55 ), lambs ( 56 ), pigs ( 57 ), sheep ( 58 ), etc. with CS supplementation, this result may be related to the lack of species specificity of SS.…”

Cysteamine Supplementation In Vitro Remarkably Promoted Rumen Fermentation Efficiency towards Propionate Production via Prevotella Enrichment and Enhancing Antioxidant Capacity

“…In animal husbandry, how to enhance the antioxidant capacity of animals has attracted more and more attention. SOD is involved in the free radical scavenging process in the body cells [ 49 ]. The GSH-Px, CAT, and T-SOD are the most vital antioxidant enzymes to eliminate unwanted lipid hydroperoxide and hydrogen peroxide [ 50 ].…”

Coated cysteamine, a potential feed additive for ruminants — An updated review

“…An increase in growth hormone has been observed from 29% (using 30% coated CS-HCl at a level of 5 g/d for 28 days in yaks [ 32 ]) to 57.42% (using 60 mg/kg BW of 50% coated CS-HCl for 64 days in lambs [ 34 ]) as compared to corresponding control groups in ruminants. In addition, CS could also enhance the production of other growth-stimulating hormones, including insulin [ 10 , 37 ], IGF-I [ 10 , 48 , 67 ], T 3 and T 4 [ 10 , 68 ] in animals. It is proposed that CS reduces the inhibitory effect of somatostatin on thyroid-stimulating hormone, which increase the concentration of GH, leading to enhanced concentration of T 3 [ 69 ].…”

“…An increase of 19.6% GSH was observed in Holstein (fed 15 g/d of 30% coated CS-HCl for 56 days [ 42 ]), 20.64% in lambs (fed 50 mg/kg BW of ≥99% CS-HCl [ 68 ]), and 26.57% in goats (fed 120 mg/kg BW of 30% coated CS-HCl for 40 days [ 48 ]). At the same time, CS could reduce the levels of malondialdehyde (MAD), which was reduced to 26.77% in lambs (fed 50 mg/kg BW of ≥99% CS-HCl [ 68 ]) and 2.64% in goats (fed 120 mg/kg BW of 30% coated CS-HCl for 40 days [ 48 ]) using CS. MAD is a biochemical marker of oxidative stress which is used as a procurator for lipid peroxidation and cellular damage in vivo [ 75 , 76 ].…”