Cysteamine (A lysosomotropic antioxidant) causes regression of atherosclerosis and improves liver and muscle function in LDL receptor deficient mice

Ahmad, Feroz; Mitchell, Robert D.; Houben, Tom; Palo, Angela; Yadati, Tulasi; Parnell, Andrew J.; Patel, Ketan; Shiri-Sverdlov, R.; Leake, DS

doi:10.1016/j.atherosclerosis.2021.06.299

Cited by 1 publication

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“…Apart from cardiovascular indexs, we measured parameters of hepatic function after treatment with different formulations. [ 37 ] No abnormal change was observed in the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among the various groups, indicating no influence on the normal physiology of the liver (Figure 7B). As shown in Figure 7C, the H&E staining assay showed that ST@MLP‐NVs significantly decreased the large vacuoles in the liver, rescuing abnormal retention of lipids.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy

Guo

Miao

Wang

et al. 2022

Adv Funct Materials

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Atherosclerosis is the underlying cause for cardiovascular disease. Current pharmacotherapies are limited by the inadequate targeting and insufficient treatment. Herein, inspired by the interaction of macro phage and lipoprotein as a typical hallmark of atherosclerosis, hybrid nano vesicles (MLPNVs) are designed by fusion of antiinflammatory M2phenotype macrophage membranes and lipidated peptide (DOPEpp HBSP) to mimic the binding manner of celllipoprotein for atherosclerotic treatment. Through hybridization of M2 macrophage membranes and lipidated peptide film, MLPNVs facilitate the inflammatory cell inter nalization at atherosclerotic site, and sequester the proinflammatory cytokines to suppress local inflammation. Moreover, MLPNVs exhibit a matrix metalloprotease 2 (MMP2)responsive release of the peptide HBSP in plaques, leading to the restoration of dysfunctional endothelial cells. In the ApoE −/− mice with atherosclerosis, simvastatinloaded MLPNVs provide comprehensive treatment by inherent inflammation suppression, endothelial repair, and cholesterol efflux capacities, resulting in athero sclerotic plaques regression. Through closely mimicking physiological cues, this biomimetic hybrid nano vesicle platform provides a potential strategy for antiatherosclerotic therapy.

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Section: Resultsmentioning

confidence: 99%