Cystatin C: Its role in pathogenesis of OSMF

Namboodiripad, P.C. Anila

doi:10.1016/j.jobcr.2014.02.004

Cited by 15 publications

(9 citation statements)

References 15 publications

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“…It is not reabsorbed by the renal tubules and is a new index for evaluating renal function. [ 23 – 25 ] Previous research [ 26 – 29 ] showed that Cys-C is significantly better than creatinine and urea nitrogen, and it can better reflect the change of GFR. This study analyzed Cys-C levels in patients with chronic HBV infection.…”

Section: Discussionmentioning

confidence: 99%

Association between serum Cystatin C and renal injury in patients with chronic hepatitis B

Zheng

Liu

Hao³

et al. 2020

Medicine

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To explore the association between serum cystatin C (Cys-C) and renal damage in patients with chronic hepatitis B. We retrospectively analyzed the clinical data of 425 patients with chronic hepatitis B virus (HBV) infection. Liver stiffness measured by FibroScan was used to diagnosis liver fibrosis. Cys-C levels were detected via latex-enhanced immunoturbidimetric assay. A total of 425 patients were enrolled. Among them, 217 were patients with CHB with an eGFR > 90 mL/min/1.73 m 2 and 208 with an eGFR ≤90 mL/min/1.73 m 2 . Cys-C levels significantly differed in patients with eGFR > 90 mL/min/1.73 m 2 compared with patients with eGFR ≤90 mL/min/1.73 m 2 (0.81 ± 0.05 vs 1.05 ± 0.06 mg/L, P < .001). Moreover, the Cys-C levels were 0.82 ± 0.04 mg/L in patients without liver fibrosis, 0.98 ± 0.05 mg/L in patients with mild liver fibrosis, 1.05 ± 0.08 mg/L in patients with advanced liver fibrosis, and 1.12 ± 0.07 mg/L in patients with liver cirrhosis ( P < .001). Multivariate analyses were conducted to explore the independent factors associated with a decreased eGFR. Multivariate analysis suggested that T2DM ( P = .032), liver fibrosis ( P = .013), and Cys-C level ( P = .035) were the independent factors associated with the decreased eGFR in patients with CHB. While age ( P = .020) and Cys-C level ( P = .001) were the independent factors associated with the decreased eGFR in patients with CHB-related fibrosis. The fibrosis group had significantly higher Cys-C levels than those without fibrosis. Routine monitoring of Cys-C levels is of positive significance in preventing the development of renal impairment of CHB patients.

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Section: Discussionmentioning

confidence: 99%

Association between serum Cystatin C and renal injury in patients with chronic hepatitis B

Zheng

Liu

Hao³

et al. 2020

Medicine

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“…Moreover, the flavonoid components in AN, like tannins and catechins, can inhibit collagenases, while arecoline or arecaidine in AN may activate TIMP-1 and reduce MMP-2 and MMP-9, decreasing collagen obliteration. 15 Lastly, copper in AN can upregulate the expression of LOX and promote collagen cross-linking, restraining collagen degradation.…”

Section: Imbalance Of Collagen Metabolismmentioning

confidence: 99%

Oral submucous fibrosis in Asian countries

Peng

Chen

et al. 2019

J Oral Pathology Medicine

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Oral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. It is precancerous and characterized by blanching and burning sensation of oral mucosa, staining of teeth and gingiva, and restricted mouth opening. It is multifactorial with a high incidence in chewers of areca nut (AN). This oral potentially malignant disorder has a high rate of malignant transformation rate (7%-30%) to oral squamous cell carcinoma (OSCC). 1 It is prevalent in Asian countries and has spread in Europe and North America. The prevalence of OSF was reported to be 1.0%-3.03% in Hunan Province, mainland China, 2 0.15%-14.4% in Vietnam, 3 and 0.086%-17.6% in Taiwan. 4 In the past decades, many efforts have been devoted to etiology, pathogenesis, and treatment of OSF. However, the research progress is still unsatisfactory. For instance, the etiology of OSF is commonly attributed to AN chewing, but some OSF patients did not have the habit. Also, there is no staging or grading scheme universally accepted and employed by clinicians, pathologists, and surgeons. Moreover, the pathogenesis and mechanism of OSF transformation into carcinomas are still obscure. Undoubtedly, it is crucial to make further studies of OSF to fill in the gaps. This article, for the first time, provided a detailed review of research advances of OSF in Asian countries, based on a comprehensive literature search using several primary databases (Figure 1), in which the terminologies, for example, OSF and oral potential malignant diseases (OPMD), were used. The OSF's etiology, histopathology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, and treatments were reviewed. The main challenges and corresponding measures were also discussed for guiding clinical research and practice concerning the disease. | E TI O LO GYOral submucous fibrosis is characterized by its multifactorial etiology. The most commonly identified factors include AN chewing, nutritional disorders, and genetic predisposition. They act individually or synergistically in the development of OSF. AbstractOral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. This oral potentially malignant disorder has a high rate of malignant transformation (7%-30%) to oral squamous cell carcinoma (OSCC), posing global problems for public health. Due to enormous efforts dedicated to this disease in the past decades, there have been significant advances in identification of its etiology and pathogenesis as well as development of corresponding therapeutic approaches, in spite of several challenges. This study reviewed the existing literature concerning OSF in Asian countries, encompassing its etiology, histopathology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, and treatments. For improving treatment of OSF, the multifactorial etiology analysis, incorporation of effective molecular pathways, cy...

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“…Researchers conducted a clinical observational study to identify molecular biomarkers from patient specimens and detect a possible link between OSF and OSCC. The common molecular markers in late-stage OSF and OSCC were cysteine proteinase inhibitor [ 122 ], TGF-β1 [ 123 ], hypoxia-inducible factor 1α (HIF-1α) [ 124 ], DNA damage phenotype [ 125 ], MMP and TIMP [ 126 ], and Cytokeratin [ 127 ] at the lesion site and elevated serum immunoglobulin G (IgG) [ 128 ]. Common alterations of the epigenetic regulation are also reported in late-stage OSF and OSCC.…”

Section: The Mechanism Of Osf Pathogenesis and Malignant Transformmentioning

confidence: 99%

Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments

Shen

Shih

Fuh

et al. 2020

IJMS

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Oral submucous fibrosis (OSF) is a collagen deposition disorder that affects a patient’s oral function and quality of life. It may also potentially transform into malignancy. This review summarizes the risk factors, pathogenic mechanisms, and treatments of OSF based on clinical and bio-molecular evidence. Betel nut chewing is a major risk factor that causes OSF in Asia. However, no direct evidence of arecoline-induced carcinogenesis has been found in animal models. Despite identification of numerous biomarkers of OSF lesions and conducting trials with different drug combinations, clinicians still adopt conservative treatments that primarily focus on relieving the symptoms of OSF. Treatments focus on reducing inflammation and improving mouth opening to improve a patient’s quality of life. In conclusion, high-quality clinical studies are needed to aid clinicians in developing and applying molecular biomarkers as well as standard treatment guidelines.

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Cystatin C: Its role in pathogenesis of OSMF

Cited by 15 publications

References 15 publications

Association between serum Cystatin C and renal injury in patients with chronic hepatitis B

Association between serum Cystatin C and renal injury in patients with chronic hepatitis B

Oral submucous fibrosis in Asian countries

Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments

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