Cystatin c and blood pressure: Results of 24h ambulatory blood pressure monitoring

Mena, Candido; Robles, Nicolás Roberto; Prado, Josefa Martin de; Gallego, Francisco García; Cidoncha, Antonio

doi:10.1016/j.ejim.2010.01.016

Cited by 15 publications

(13 citation statements)

References 43 publications

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“…Already mild reduction in renal function has been implicated in the pathogenesis of primary hypertension, as significant associations have been found between higher serum cystatin C concentrations and the incidence and prevalence of hypertension among the general population. However, several previous studies examining the relationship between BP and kidney function have included patients medicated with BP‐lowering drugs and other agents with direct cardiovascular actions …”

Section: Discussionmentioning

confidence: 99%

Lower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease

Vääräniemi

Koskela

Tahvanainen

et al. 2014

J of Clinical Hypertension

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The authors examined the association between estimated glomerular filtration rate (eGFR), calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine‐cystatin C equation, and hemodynamics in 556 normotensive or never‐treated hypertensive patients without kidney disease (mean age, 46 years). Hemodynamic variables were recorded using pulse wave analysis and whole‐body impedance cardiography. The mean eGFR was 98 mL/min/1.73 m2 (range, 64–145 mL/min/1.73 m2 and one third of the patients had values below 92, while none had proteinuria. In linear regression analyses adjusted for differences in age, weight:height ratio, low‐density lipoprotein cholesterol, and sex, significant associations were found between lower eGFR and higher systolic (P=.001) and diastolic blood pressure (P<.001) and higher systemic vascular resistance (P=.001). There was no association between eGFR and cardiac output or extracellular volume. In the absence of clinical kidney disease, lower eGFR was associated with higher blood pressure and systemic vascular resistance. Therefore, early impairment in kidney function may be involved in the pathogenesis of essential hypertension.

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Section: Discussionmentioning

confidence: 99%

Lower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease

Vääräniemi

Koskela

Tahvanainen

et al. 2014

J of Clinical Hypertension

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“…Cystatin C should be a predictor of microalbuminuria in the early stages of hypertension and, thus, predict cardiovascular events beyond its use as a marker of renal function 36 . In addition, CysC showed a positive correlation with the number of metabolic syndrome criteria in patients with dyslipidemia, regardless of creatinine levels and Modification of Diet in Renal Disease (MDRD) 37 .…”

Section: Discussionmentioning

confidence: 99%

Cystatin C, CRP, Log TG/HDLc and Metabolic Syndrome are Associated with Microalbuminuria in Hypertension

Moura¹,

Vasconcelos²,

Freitas³

et al. 2013

Arquivos Brasileiros De Cardiologia

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Background In patients with systemic hypertension, microalbuminuria is a marker of endothelial damage and is associated with an increased risk for cardiovascular disease. Objective To determine the factors that may lead to the occurrence of microalbuminuria in hypertensive patients with serum creatinine lower than 1.5 mg/dL. Methods This cross-sectional study included 133 Brazilians with essential hypertension followed up at a hypertension outpatient clinic. Those with serum creatinine higher than 1.5 mg/dL, as well as those with diabetes mellitus, were excluded. Systolic and diastolic blood pressures were measured, and body mass index (BMI) and GFR estimated by using the CKD-EPI formula were calculated. The serum levels of the following were assessed: CysC, creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, C-reactive protein (CRP) and fasting glucose. Microalbuminuria was determined in 24-hour urine. Hypertensive patients were classified according to the presence of one or more criteria for metabolic syndrome. Results In a multiple regression analysis, the serum levels of CysC and CRP, the atherogenic index log TG/HDLc and the presence of three or more criteria for metabolic syndrome were positively correlated with microalbuminuria (r2: 0.277, p < 0.05). Conclusion CysC, CRP, log TG/HDLc, and the presence of three or more criteria for metabolic syndrome, regardless of serum creatinine, were associated with microalbuminuria, an early marker of kidney damage and cardiovascular risk in patients with essential hypertension.

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“…Namely, Salgado et al (22) reported the association of SBP, but not DBP, with serum cystatin C levels. On the other hand, Mena et al (23) found that DBP negatively correlated with cystatin C, while Shankar et al (24) confirmed that mild reductions in kidney function as measured by serum cystatin C levels among subjects without clinically recognized chronic kidney disease were associated with hypertension in women, but not in men.…”

Section: Discussionmentioning

confidence: 78%

Cystatin C in healthy middle-aged adults: A relationship with anthropometric and cardiometabolic parameters

Jovanović

Kavarić

Gligorovic-Barhanovic

et al. 2016

JHSCI

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Cystatin c and blood pressure: Results of 24h ambulatory blood pressure monitoring

Cited by 15 publications

References 43 publications

Lower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease

Lower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease

Cystatin C, CRP, Log TG/HDLc and Metabolic Syndrome are Associated with Microalbuminuria in Hypertension

Cystatin C in healthy middle-aged adults: A relationship with anthropometric and cardiometabolic parameters

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