Cystatin C: A useful marker of glomerulopathy in sickle cell disease?

Asnani, Monika; Reid, Marvin

doi:10.1016/j.bcmd.2014.07.018

Cited by 26 publications

(34 citation statements)

References 53 publications

(65 reference statements)

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“…The prevalence of glomerular hyperfiltration was comparable to previous studies of patients in French and West Indian cohorts (Haymann et al , ; Arlet et al , ), and Congolese HbSS children also displayed a similar prevalence of hyperfiltration (Aloni et al , , ). Among Jamaicans living with SCD, up to half of the hyper‐filtrating individuals might also have micro‐albuminuria (Asnani & Reid, , ), further supporting the fact that the state of hyperfiltration is an early pathology in those likely to progress to CKD. Vazquez et al () have similarly described increasing rates of development of microalbuminuria with increasing levels of hyperfiltration.…”

Section: Discussionmentioning

confidence: 96%

“…The result indicates that the majority of SCD patients in this sample of Cameroonians presented with micro‐albuminuria, as well as a high prevalence of glomerular hyperfiltration. Micro‐albuminuria is considered the primary marker of early renal dysfunction (Ataga et al , ; Gosmanova et al , ), conferring increased risk of CKD and ESKD development and, ultimately, premature mortality, indicating the need for routine early detection (Asnani & Reid, ,b). The high prevalence of micro‐ and macro‐albuminuria in our SCD cohort differs with previous occurrence rates of 40% and 19% in adult Americans living with SCD (Haymann et al , ), 25·9% and 16·5% in Jamaican SCD patients (Asnani et al , ), 28·2% among SCD children in Uganda (Mawanda et al , ), and 50% combined prevalence rate reported in Nigerian patients (Bolarinwa et al , ).…”

Section: Discussionmentioning

confidence: 99%

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Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon

et al. 2017

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SUMMARY Micro-albuminuria and glomerular hyperfiltration are primary indicators of renal dysfunctions in Sickle Cell Disease (SCD), with more severe manifestations previously associated with variants in APOL1 and HMOX1 among African Americans. We have investigated 413 SCD patients from Cameroon. Anthropometric variables, haematological indices, crude albuminuria, albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. Patients were genotyped for 3.7 kB alpha-globin gene (HBA1/HBA2) deletion, and for variants in APOL1 (G1/G2; rs60910145, rs73885319, rs71785313) and HMOX1 (rs3074372, rs743811). The median age was 15 years; the majority presented with micro-albuminuria (60.9%; n = 248), and approximately half with glomerular hyperfiltration (49.5%; n = 200). Age, male sex, haemoglobin level, leucocyte count, mean corpuscular volume, blood pressure, body mass index and creatinine levels significantly affected albuminuria and/or eGFR. Co-inheritance of alpha-thalassaemia was protective against macro-albuminuria (p = 0.03). APOL1 G1/G2 risk variants were significantly associated with the ACR (p = 0.01) and borderline with eGFR (p = 0.07). HMOX1 - rs743811 was borderline associated with micro-albuminuria (p = 0.07) and macro-albuminuria (p = 0.06). The results revealed a high proportion of micro-albuminuria and glomerular hyperfiltration among Cameroonian SCD patients, and support the possible use of targeted genetic biomarkers for risks assessment.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon

et al. 2017

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“…In fact, creatinine-based estimation equations for GFR all appear to overestimate kidney function when compared to radionucleotide measures of GFR [32]. Because of this phenomenon, cystatin C has been suggested as a more accurate marker of CKD in both children and adults with SCD with GFR greater than 30 mL/min/1.73 m 2 [27,33]. In SCT, cystatin C-based eGFR was associated with higher prevalence of low eGFR <60 mL/min/1.73 m 2 compared to creatinine-based estimations, but correlations with direct measures of GFR have not been investigated [34].…”

Section: Epidemiologymentioning

confidence: 99%

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

Naik

Derebail

2017

Expert Review of Hematology

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Introduction Renal dysfunction is among the most common complication of sickle cell disease (SCD), from hyposthenuria in children to progression to overt chronic kidney disease (CKD) in young adults. Emerging evidence now suggests that sickle hemoglobin-related nephropathy extends to individuals with sickle cell trait (SCT). Areas covered This review will highlight the pathophysiology, epidemiology, and management recommendations for sickle hemoglobin-related nephropathy in both SCD and SCT. In addition, it will focus on the major demographic and genetic modifiers of renal disease in sickling hemoglobinopathies. Expert commentary Studies have elucidated the course of renal disease in SCD; however, the scope and age of onset of renal dysfunction in SCT has yet to be determined. In SCD, several modifiers of renal disease – such as α-thalassemia, hemoglobin F, APOL1 and HMOX1 – have been described and provide an opportunity for a precision medicine approach to risk stratify patients who may benefit from early intervention. Extrapolating from this literature may also provide insight into the modifiers of renal disease in SCT. Further studies are needed to determine the optimal treatment for sickle hemoglobin-related nephropathy.

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“…Renal disease is one of the foremost complications in individuals with sickle cell disease (SCD), with sickle‐related nephropathy becoming a more frequent presentation as those affected live for longer (Serjeant et al , ; Sharpe & Thein, ). In fact, chronic kidney disease (CKD) and end stage renal disease (ESRD) are a leading cause of morbidity and mortality in older individuals with SCD, and hence routine monitoring for early detection of renal problems is recommended during health maintenance visits (Asnani & Reid, ,b). The glomerular filtration rate (GFR) is thought to be the most ideal marker of renal function in humans, both in health and disease, however its measurements tend to be cumbersome and expensive (Xie et al , ).…”

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confidence: 99%

Predictors of renal function progression in adults with homozygous sickle cell disease

Asnani

Serjeant²,

Royal-Thomas

et al. 2016

Br J Haematol

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Longitudinal studies of renal function may improve understanding of the pathophysiological mechanisms underlying sickle cell disease (SCD) nephropathy and may identify possible biological and clinical markers of renal function determined over time. Data from the Jamaica Sickle Cell Cohort Study (JSCCS) were extracted and the glomerular filtration rate (GFR) was estimated using the Chronic Kidney Disease Epidemiological and the SCD specific JSCCS-GFR equations from all adulthood serum creatinine measurements in homozygous SS patients. The other dataset consisted of measured GFR at two times about 13 years apart. Linear mixed model (LMM) regression analyses were conducted to determine predictors of GFR and serum creatinine over time. 191 individuals with SS disease had 867 GFR estimates available. Serum creatinine significantly increased from baseline whereas estimated GFR showed a significant decline. Serum creatinine showed positive association with increasing age, male gender, body mass index and sodium levels. Haemoglobin was a significant negative predictor of estimated GFR in age- and gender-adjusted models. A total of 24 females and 17 males had repeat measurements of their GFR. The mean annual decline in GFR was -3·2 ± 2·83 ml/min/1·73 m(2) . Haemoglobin was a significant positive predictor whereas serum creatinine, systolic blood pressure and urinary albumin: creatinine ratio were negative predictors of GFR.

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Cystatin C: A useful marker of glomerulopathy in sickle cell disease?

Cited by 26 publications

References 53 publications

Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon

Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

Predictors of renal function progression in adults with homozygous sickle cell disease

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