Cystatin C – A Fast and Reliable Biomarker for Glomerular Filtration Rate in Head and Neck Cancer Patients

Bölke, Edwin; Schieren, Gisela; Gripp, Stephan; Steinbach, Gerald; Peiper, Matthias; Orth, Klaus; Matuschek, Christiane; Pelzer, M.; Lammering, Guido; Houben, Ruud; Antke, Christina; Rump, Lars Christian; Mota, Rodrigo; Gerber, Peter Arne; Schuler, Patrick J.; Hoffmann, Thomas; Rusnak, E; Hermsen, Derik; Budach, Wilfried

doi:10.1007/s00066-010-2203-5

Cited by 24 publications

(22 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[25][26][27] However, in a study regarding head and neck cancers, cystatin C was noted as a proper parameter for GFR measurement. 17 No correlation was found between the advanced tumor grade and cystatin C level in our study. Studies with larger patient groups will be necessary to prove that the serum cystatin C level is a proper method in determining the cisplatininduced renal damage.…”

Section: Discussioncontrasting

confidence: 68%

“…[12][13][14][15] Some studies have demonstrated that cystatin C was a better indicator in determining the renal function compared to creatinine in the patients receiving cisplatinbased chemotherapy. 8,[16][17][18] Furthermore, it was reported that cystatin C was found in higher concentrations in the tissues and body fluids of breast and prostate cancer patients and this was correlated with the aggressive form of the cancer. 19,20 The aim of our study was to evaluate the correlation of the serum cystatin C levels with the serum creatinine levels and GFR calculated by CockcroftGault and MDRD formulations in the patients who received cisplatin-based chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Renal Function Using Cystatin C Level in the Patients Receiving Cisplatin-Based Chemotherapy

et al. 2013

View full text Add to dashboard Cite

Objective: There are some data regarding the role of cystatin C, a cysteine proteinase inhibitor, in determining the glomerular filtration rate (GFR) more accurately. We aimed to evaluate the correlation of serum cystatin C levels with the serum creatinine levels and GFR calculated by Cockcroft-Gault and modification of diet in renal disease (MDRD) formulations in the patients who received cisplatin-based chemotherapy. We also intended to demonstrate its potential use in the early prediction of the renal function changes in these patients. Materials and methods: In the study, 34 patients receiving cisplatin-based chemotherapy with various malignancies were included. The levels of cisplatin were determined prior to the chemotherapy and at the end of cisplatin infusion during the therapy. GFR was calculated by Cockcroft-Gault and MDRD formulations prior to the therapy and at the end of the third course. Results: A statistically significant linear correlation was found between the serum levels of cystatin C and creatinine prior to the chemotherapy (r ¼ 0.42, p ¼ 0.013). However, there was no correlation among the level of cystatin C subsequent to the cisplatin infusion and serum creatinine level following the third course and MDRD and creatinine clearance-Cockcroft-Gault formulations. Conclusion: Even though the serum cystatin C levels were correlated with the serum creatinine levels in our study, it was concluded that it was not an appropriate parameter to predict the potential impairments in the renal function during the chemotherapy.

show abstract

Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Renal Function Using Cystatin C Level in the Patients Receiving Cisplatin-Based Chemotherapy

et al. 2013

View full text Add to dashboard Cite

show abstract

“…These findings are in accordance with the results of Salek et al [13]. This is likely because creatinine is not only filtrated through glomeruli, but is also secreted from the proximal tubuli, leading to overestimation [23]. eGFR scr is the current equation recommended for use in clinical practice [24].…”

Section: Discussionsupporting

confidence: 89%

Evaluation of Serological Indicators and Glomerular Filtration Rate Equations in Chinese Cancer Patients

et al. 2017

View full text Add to dashboard Cite

BackgroundThe performance of estimated glomerular filtration rate (eGFR) have been proved to vary according to the races of the target population. The eGFR equations have not been validated in the Chinese cancer population received chemotherapy. Meanwhile, serum cystatin C (CysC), urea, β2 microglobulin (β2-MG), and creatinine (SCr) were also evaluated in a cohort of Chinese cancer patients.Material/MethodsA total of 1000 cancer patients undergoing combination chemotherapy and 108 healthy volunteers were included in this study, and their renal function parameters were evaluated. The eGFR values were compared with reference GFR (rGFR) according to correlation, consistency, precision, and accuracy. Receiver operating characteristic (ROC) curves were used to evaluate the discriminating ability of the GFR equations and serological indicators of renal function.Results(1) The equations contained CysC had the same varying tendency as rGFR in relation to the chemotherapeutic cycle. (2) eGFRscr+cysc and eGFRChinese scr+cysc worked better than the other equations, as indicated by a stronger correlation, less bias, improved precision, higher accuracy, and greater AUC. (3) CysC was more sensitive than the other serological indicators for identifying early renal injury. (4) Each parameter showed different characteristics in subgroups of Chinese cancer patients.ConclusionsCysC was the most sensitive marker for early renal injury. Among the 8 most commonly used eGFR equations, the combination equation eGFRscr+cysc and eGFRChinese scr+cysc exhibited the best performance in the assessment of the renal function of Chinese cancer patients.

show abstract

“…It is expressed at a constant rate in all nucleated cells. Because cystatin C is cleared exclusively through the kidney, its concentration depends solely on the GFR and is unaffected by muscle mass, age, race, or gender (13) . Many investigations have shown that CysC is superior to sCr as a marker for AKI (5) .…”

Section: Introductionmentioning

confidence: 99%

Serum cystatin C is an early biomarker for assessment of renal function in burn patients

Cai

Long

Lin

et al. 2012

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

show abstract

Cystatin C – A Fast and Reliable Biomarker for Glomerular Filtration Rate in Head and Neck Cancer Patients

Abstract: Cystatin C-based GFR estimates showed the overall strongest correlation to the reference method. Thus, we recommend cystatin C for GFR estimation in HNC patients as an alternative method to the estimated creatinine clearance in clinical practice.

Cited by 24 publications

References 32 publications

Evaluation of the Renal Function Using Cystatin C Level in the Patients Receiving Cisplatin-Based Chemotherapy

Evaluation of the Renal Function Using Cystatin C Level in the Patients Receiving Cisplatin-Based Chemotherapy

Evaluation of Serological Indicators and Glomerular Filtration Rate Equations in Chinese Cancer Patients

Serum cystatin C is an early biomarker for assessment of renal function in burn patients

Contact Info

Product

Resources

About