Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment

Kolluru, Gopi K.; Bir, Shyamal C.; Yuan, Shuai; Shen, Xinggui; Pardue, Sibile; Wang, Rui; Kevil, Christopher G.

doi:10.1093/cvr/cvv198

Cited by 56 publications

(83 citation statements)

References 55 publications

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“…These results were extrapolated in vivo ; rats exposed to hypobaric hypoxic exhibited increased CBS expression and activity in the cerebellum and cortex. Moreover, it was recently shown that chronic hypoxia increased tissue H 2 S levels and CSE activity in a mouse model of hind limb ischemia [45]. Increases in tissue H 2 S levels, albeit smaller, were also noted in CSE KO.…”

Section: Hypoxia and H2smentioning

confidence: 95%

“…t CSE inhibition or silencing reduces tube length of endothelial progenitor cells (EPC) on Matrigel® and inhibits EPC adhesion to the matrix [77]. Moreover, the number of circulating and homed EPCs were significantly reduced in CSE KO mice following an ischemic challenge, proving further evidence for a role of H 2 S in EPC biology [45]. Clearly, additional studies are needed to fully elucidate the impact of H 2 S on EPC behavior.…”

Section: Effect Of Endogenous H2s On Angiogenic Properties Of Endothementioning

confidence: 99%

“…Although H 2 S might not be required for bFGF angiogenic signaling, H 2 S up regulates bFGF levels in vivo . bFGF along with VEGF and interleukin-16 were increased following hind limb ischemia in wild-type mice; this response was reduced in CSE KO animals [45]. Recent reports showed that H 2 S reduced angiopoietin-2 production but none of them studied this effect in the context of angiogenesis [84, 85].…”

Section: Interplay Between H2s and Angiogenic Factorsmentioning

confidence: 99%

“…The role of endogenous H 2 S has also been studied in a number of pathophysiological conditions associated with angiogenesis, including wound healing, critical limb ischemia and cancer [30, 45, 70]. Burn wounds in CSE KO mice healed at a slower rate compared to those of wild-type control mice [30].…”

Section: Effect Of Endogenous H2s On Angiogenic Properties Of Endothementioning

confidence: 99%

“…Mature vessel density, angiogenic indices and blood flow were significantly reduced in CSE KO mice compared with WT mice with femoral artery ligation [45]; administration of diallyl disulfide restored these parameters. In line with this notion, patients with critical limb ischemia exhibit reduced levels of all three H 2 S generating enzymes and attenuated H 2 S bioavailability accompanied by increased oxidative stress [105].…”

Section: Effect Of Endogenous H2s On Angiogenic Properties Of Endothementioning

confidence: 99%

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Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Katsouda

Bibli

Pyriochou

et al. 2016

Pharmacological Research

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Recent studies have implicated endogenously produced H2S in the angiogenic process. On one hand, pharmacological inhibition and silencing of the enzymes involved in H2S synthesis attenuate the angiogenic properties of endothelial cells, including proliferation, migration and tube-like structure network formation. On the other hand, enhanced production of H2S by substrate supplementation or over-expression of H2S-producing enzymes leads to enhanced angiogenic responses in cultured endothelial cells. Importantly, H2S up-regulates expression of the key angiogenic factor vascular endothelial growth factor (VEGF) and contributes to the angiogenic signaling in response to VEGF. The signaling pathways mediating H2S-induced angiogenesis include mitogen-activated protein kinases, phosphoinositide-3 kinase, nitric oxide/cGMP-regulated cascades and ATP-sensitive potassium channels. Endogenously produced H2S has also been shown to facilitate neovascularization in prototypical model systems in vivo, and to contribute to wound healing, post-ischemic angiogenesis in the heart and other tissues, as well as in tumor angiogenesis. Targeting of H2S synthesizing enzymes might offer novel therapeutic opportunities for angiogenesis-related diseases.

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Section: Hypoxia and H2smentioning

confidence: 95%

Section: Effect Of Endogenous H2s On Angiogenic Properties Of Endothementioning

confidence: 99%

Section: Interplay Between H2s and Angiogenic Factorsmentioning

confidence: 99%

Section: Effect Of Endogenous H2s On Angiogenic Properties Of Endothementioning

confidence: 99%

Section: Effect Of Endogenous H2s On Angiogenic Properties Of Endothementioning

confidence: 99%

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Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Katsouda

Bibli

Pyriochou

et al. 2016

Pharmacological Research

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Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Disbrow

Stokes

Ledbetter

et al. 2021

Alzheimer's & Dementia

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While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H2S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H2S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H2S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.

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Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

Rajendran

Shen

Glawe

et al. 2019

Comprehensive Physiology

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Ischemic vascular remodeling occurs in response to stenosis or arterial occlusion leading to a change in blood flow and tissue perfusion. Altered blood flow elicits a cascade of molecular and cellular physiological responses leading to vascular remodeling of the macro- and microcirculation. Although cellular mechanisms of vascular remodeling such as arteriogenesis and angiogenesis have been studied, therapeutic approaches in these areas have had limited success due to the complexity and heterogeneous constellation of molecular signaling events regulating these processes. Understanding central molecular players of vascular remodeling should lead to a deeper understanding of this response and aid in the development of novel therapeutic strategies. Hydrogen sulfide (H2S) and nitric oxide (NO) are gaseous signaling molecules that are critically involved in regulating fundamental biochemical and molecular responses necessary for vascular growth and remodeling. This review examines how NO and H2S regulate pathophysiological mechanisms of angiogenesis and arteriogenesis, along with important chemical and experimental considerations revealed thus far. The importance of NO and H2S bioavailability, their synthesis enzymes and cofactors, and genetic variations associated with cardiovascular risk factors suggest that they serve as pivotal regulators of vascular remodeling responses.

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Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment

Abstract: Endogenous CSE/H2S regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment and cytokine induction revealing a previously unknown mechanism of arteriogenesis.

Cited by 56 publications

References 55 publications

Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

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