Cystadenocarcinoma of the salivary glands with potential lymph node metastasis

Mukaigawa, Takashi; Hayashi, Ryuichi; Miyazaki, Masakazu; Shinozaki, Takahiro; Tomioka, Toshifumi; Fujii, Satoshi

doi:10.1016/j.anl.2015.08.012

Cited by 9 publications

(9 citation statements)

References 8 publications

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“…These patients were rescued by surgery. However, these findings suggest that local recurrence [5] and cervical lymph node recurrence could be more common than previously thought in papillary cystadenocarcinoma [9][10][11][12]. In contrast to local recurrence [5] and/or regional lymph node metastasis, our case developed pulmonary metastasis, which is an extremely rare clinical manifestation during the clinical course of papillary cystadenocarcinoma.…”

Section: Discussioncontrasting

confidence: 64%

“…Foss et al [ 3 ] reported 40 cases of cystadenocarcinoma, 4 of which (10%) presented with regional lymph node metastases, and 3 (7.7%) showed local recurrence at an average of 76 months after initial treatment. In addition, there were some reports of a high-grade malignant variant that led to relatively high rates of metastasis for regional lymph node and recurrence with rapid progression [ 6 , 7 , 8 , 9 , 10 , 11 ]. These patients were rescued by surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been several case reports of local recurrence after surgical resection and/or regional lymph node metastasis at initial presentation or during the clinical course [6][7][8][9][10][11], the progression of distant metastasis is poorly understood. We encountered an unusual case of papillary cystadenocarcinoma arising from the maxillary gingiva that developed pulmonary metastasis 3 years after radical surgery of the primary tumor and regional lymph node.…”

Section: Introductionmentioning

confidence: 99%

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A Rare Distant Metastasis of Papillary Cystadenocarcinoma Arising from Maxillary Gingiva

et al. 2020

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Papillary cystadenocarcinoma is an uncommon disease with low-grade histological and clinical features. Although the tumor has the potential to produce regional lymph node metastasis, there have been no reports of cases with distant metastasis. We describe a case of papillary cystadenocarcinoma arising from the maxilla that developed pulmonary metastasis 3 years after radical surgery of the primary tumor and regional lymph node. The histological findings were confirmed on resected specimens of the pulmonary nodule and a pathological diagnosis of a metastatic lesion derived from papillary cystadenocarcinoma was made. To our knowledge, this is the first report of the development of pulmonary metastasis in a patient with papillary cystadenocarcinoma. The present case suggests that papillary cystadenocarcinoma has the potential to produce lung metastasis in the clinical course. Based on our experience, we emphasize that long-term follow-up and/or careful examination are necessary in patients with cystadenocarcinoma, especially in patients with lymph node metastasis during the initial surgical therapy.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Rare Distant Metastasis of Papillary Cystadenocarcinoma Arising from Maxillary Gingiva

et al. 2020

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“…Mills et al16 reported that three of five patients (60%) with cystadenocarcinoma of the salivary gland had cervical lymph node metastases after 2–21 years. Similarly, Mukaigawa et al15 reported on four patients with cystadenocarcinoma of the salivary gland who underwent radical resection, where two patients underwent lymph node dissection, and three patients had cervical lymph node recurrence after 7, 17, and 24 months (with parotid lymph node recurrence after 43 months), respectively. Foss et al reported that one patient had regional lymph node metastasis after 55 months and three patients had lymphatic metastasis at initial diagnosis 3.…”

Section: Discussionmentioning

confidence: 91%

“…Lymphadenectomy is recommended for patients with lymph node enlargement 14. The main site of recurrence following radical resection is the cervical lymph nodes, and there is less recurrence in the primary tumor bed 3,15. Mills et al16 reported that three of five patients (60%) with cystadenocarcinoma of the salivary gland had cervical lymph node metastases after 2–21 years.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics, treatment, and survival outcomes of cystadenocarcinoma of the salivary gland: a population-based study

Cai

Sun

et al. 2016

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BackgroundThe aim of this study was to investigate the clinicopathological characteristics, treatment, and survival of cystadenocarcinoma of the salivary gland.Patients and methodsCases in the Surveillance, Epidemiology, and End Results database from 1991 to 2012 were identified. Factors significantly associated with survival were identified using Kaplan–Meier survival analysis and Cox proportional hazard regression.ResultsA total of 65 patients were identified; of these patients, 64 received surgical treatment, 25 underwent lymphadenectomy, and four (16.0%) patients had nodal metastasis and only one (2.1%) patient had poorly differentiated disease. The most common tumor location was the parotid gland (87.7%). The median follow-up was 55 months. None of the patients died of salivary gland malignant-tumor-related disease. The 5- and 10-year cause-specific survival rates were 97.0% and 81.4%, respectively. The 5- and 10-year overall survival rates were 84.6% and 60.7%, respectively. Surgical procedures, lymphadenectomy, and adjuvant radiotherapy did not affect survival.ConclusionSalivary gland cystadenocarcinoma is extremely rare but has an excellent prognosis, and surgery is the mainstay of treatment.

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