Cyst-Like Schwannoma on the Eyelid Margin

Abstract

Schwannomas are benign tumors originating from Schwann cells. We describe a rare case of solitary schwannoma on the eyelid margin. To our knowledge, this is the first clinical report of such a lesion on the eyelid margin, confirmed by both extensive immunohistochemical analysis and its distinctive morphology. Although schwannomas seldom undergo malignant change, they should be considered in the differential diagnosis of palpebral lesions.

Isolated Schwannoma of the Upper Eyelid Margin in a 50-year-old Male

“…Schwannoma of the eyelid margin in adults was first reported in 2007 by Lopez-Tizon et al 8 The second report was in 2012, by Cheng et al 9 The first reported case of an eyelid margin Schwannoma was a slowly enlarging 0.4 cm nodule, thought to be an inclusion cyst on the right upper eyelid margin for 1 year, which did not recur for 12 years after pentagonal full-thickness excision. The second report was a 35-year-old man who presented with a translucent, painless, cyst-like nodule with a smooth surface located on the right lower eyelid margin, resembling hidrocystoma and treated by shave excision.…”

Nasopalpebral Schwannomas and Human Immunodeficiency Virus Infection

“…The clinical consequences of palpebral tumors might be more life threatening than those of the nasal ones. Palpebral schwannomas are rare, with less than 20 cases being reported to date to our knowledge [ 4 ]. They are more frequently less than 10 mm in size [ 4 ].…”

“…Palpebral schwannomas are rare, with less than 20 cases being reported to date to our knowledge [ 4 ]. They are more frequently less than 10 mm in size [ 4 ]. In the case we present, there was no cystic change as previously reported [ 4 ] but rare macrophages arranged in sheets or subendothelially.…”

“…They are more frequently less than 10 mm in size [ 4 ]. In the case we present, there was no cystic change as previously reported [ 4 ] but rare macrophages arranged in sheets or subendothelially. Several factors such as dyslipidemia or injected contrast substance, as noted in the present case, could have contributed to the development of this morphological peculiarity in schwannomas.…”

A patient with periorbital pain: A case of isolated schwannoma of the eyebrow

“…It has been reported that some hereditary diseases such as neurofibromatosis, schwannomatosis and Carney complex are associated with multiple schwannomas [4] . There are only a few case reports with lower and upper eyelid involvement in the English-language literature [4][5][6][7][8][9][10][11][12][13][14][15] . In this report, an isolated schwannoma case with eyebrow involvement on the trajectory of the supraorbital nerve in a 24-year-old male patient is presented.…”