Cyr61 promotes Schwann cell proliferation and migration via αvβ3 integrin

Cheng, Zhenghui; Zhang, Yawen; Tian, Yinchao; Chen, Yuhan; Ding, Fei; Wu, Hanjiang; Ji, Yuhua; Shen, Mi

doi:10.1186/s12860-021-00360-y

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…However, the targets of AUF1 are likely to be cell-type specific. Querying published papers revealed a number of genes that could be the exact targets for AUF1 that lead to cell proliferation, including AMH, SPARC, FOXG1, CYR61, PLSCR1 and SP100 (37)(38)(39)(40)(41)(42). These genes were explored by RNA-Seq in the present study.…”

Section: Discussionmentioning

confidence: 99%

Role of AUF1 in modulating the proliferation, migration and senescence of skin cells

Wang

et al. 2021

Exp Ther Med

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AU-rich element RNA-binding factor 1 (AUF1) is a classical RNA-binding protein. AUF1 influences the process of development, apoptosis and tumorigenesis by interacting with adenylate-uridylate rich element-bearing mRNAs. Human skin is the largest organ of the body and acts as a protective barrier against pathogens and injuries. The aim of the present study was to explore the function and potential molecular pathways of AUF1 in human skin cells. AUF1 was overexpressed in human keratinocyte HaCaT cells and human skin fibroblast WS1 cells using adenoviruses and silenced using lentiviruses. AUF1 overexpression facilitated cell proliferation, whereas AUF1 knockdown induced the opposite effect. AUF1 reduced apoptosis but did not affect cell cycle progression. Forced AUF1 expression promoted the migration of human skin cells, as demonstrated by a scratch wound healing assay. Cell senescence was alleviated in AUF1-overexpressing skin cells, while AUF1 knockdown increased cell senescence. WS1 cells with AUF1 overexpression and silencing were used for RNA-sequencing and Kyoto Encyclopedia of Genes and Genomes-based pathway analysis to identify AUF1-affected mRNAs. A total of 18 mRNAs (eight mRNAs with positive associations and 10 mRNAs with negative associations) revealed consistent associations with both AUF1 overexpression and silencing. Enriched pathways associated with AUF1 expression included ‘MAPK’, ‘cell adhesion molecules’, ‘proteasome’, ‘cellular senescence’ and ‘TGF-β signaling’, indicating a complex regulatory network. Overall, the results of the present study revealed that AUF1 is involved in the proliferation, migration and senescence of skin cells in vitro and may be a potential target for cosmetic and disease treatment of skin.

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Section: Discussionmentioning

confidence: 99%

Role of AUF1 in modulating the proliferation, migration and senescence of skin cells

Wang

et al. 2021

Exp Ther Med

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“…Previous study has indicated numerous methods that could promote the proliferation and migration of SCs [35][36][37]. However, these methods frequently involve in complex, difficult to be popularized, and what is more, these factors cannot enhance SC proliferation in the early stage by one hand and further promote SC migration in the late stage by the other hand.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Derived Cells Mediated Regulation of Schwann Cells Proliferation and Migration In vitro

Yan¹,

Wu²

2022

J Surgery

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Schwann cells (SCs) are the unique glial cells in the peripheral nerve. After peripheral nerve injury, SCs change their morphology, function, and play a new role as repair cells, through this process, factors that enhance SCs proliferation and promote SCs migration will benefit nerve regeneration and functional recovery. Bone marrow-derived cells (BMDCs), which has been proved to offer several regenerative benefits for tissue and organ injuries. However, whether BMDCs support nerve regeneration by affect the proliferation and migration of SCs, remains unclear. Here, we taken BMDCs co-cultured with nerve segments, and then investigated the proliferation and migration of SCs In vitro. Results demonstrated that BMDCs can enhance the proliferation of SCs, and then promoted SCs migration, forming Bungner’s brand-liked structure In vitro. These finding provide a potential new method for repair of injured peripheral nerves in clinical.

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“…Besides NTFs, a number of other biological agents have emerged that show regenerative properties in neurodegenerative diseases, such as vascular endothelial growth factor (VEGF) [ 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 ], insulin-like growth factors (IGFs) [ 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 ], the cellular communication network (CCN) family [ 204 , 205 , 206 , 207 , 208 ], and erythropoietin (EPO) [ 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 ], with varying, but also promising results.…”

Section: Challenges and Future Perspective Of The Use Of Ntfs In Neur...mentioning

confidence: 99%

Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives

Ouaamari

Bos

Willekens

et al. 2023

IJMS

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Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic lateral sclerosis (ALS), are characterized by acute or chronic progressive loss of one or several neuronal subtypes. However, despite their increasing prevalence, little progress has been made in successfully treating these diseases. Research has recently focused on neurotrophic factors (NTFs) as potential regenerative therapy for neurodegenerative diseases. Here, we discuss the current state of knowledge, challenges, and future perspectives of NTFs with a direct regenerative effect in chronic inflammatory and degenerative disorders. Various systems for delivery of NTFs, such as stem and immune cells, viral vectors, and biomaterials, have been applied to deliver exogenous NTFs to the central nervous system, with promising results. The challenges that currently need to be overcome include the amount of NTFs delivered, the invasiveness of the delivery route, the blood–brain barrier permeability, and the occurrence of side effects. Nevertheless, it is important to continue research and develop standards for clinical applications. In addition to the use of single NTFs, the complexity of chronic inflammatory and degenerative diseases may require combination therapies targeting multiple pathways or other possibilities using smaller molecules, such as NTF mimetics, for effective treatment.

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Cyr61 promotes Schwann cell proliferation and migration via αvβ3 integrin

Cited by 8 publications

References 44 publications

Role of AUF1 in modulating the proliferation, migration and senescence of skin cells

Role of AUF1 in modulating the proliferation, migration and senescence of skin cells

Bone Marrow Derived Cells Mediated Regulation of Schwann Cells Proliferation and Migration In vitro

Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives

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