2011
DOI: 10.1186/1476-4598-10-8
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Abstract: BackgroundDespite recent advances in outlining the mechanisms involved in pancreatic carcinogenesis, precise molecular pathways and cellular lineage specification remains incompletely understood.ResultsWe show here that Cyr61/CCN1 play a critical role in pancreatic carcinogenesis through the induction of EMT and stemness. Cyr61 mRNA and protein were detected in the early precursor lesions and their expression intensified with disease progression. Cyr61/CCN1 expression was also detected in different pancreatic … Show more

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Cited by 88 publications
(113 citation statements)
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References 49 publications
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“…Bioinformatic analysis of a microarray dataset demonstrated that CYR61 expression was increased in PDAC samples compared with matched normal adjacent tissue ( Figure 3A and B), supporting increased CYR61 expression in PDAC, consistent with a prior report (32). Further analysis demonstrated that patients with familial PanIN precursor lesions (27) have an intermediate level of CYR61 ( Figure 3C).…”
Section: Cyr61 Expression Is Increased In Pdacsupporting
confidence: 73%
“…Bioinformatic analysis of a microarray dataset demonstrated that CYR61 expression was increased in PDAC samples compared with matched normal adjacent tissue ( Figure 3A and B), supporting increased CYR61 expression in PDAC, consistent with a prior report (32). Further analysis demonstrated that patients with familial PanIN precursor lesions (27) have an intermediate level of CYR61 ( Figure 3C).…”
Section: Cyr61 Expression Is Increased In Pdacsupporting
confidence: 73%
“…In a report recently published (Haque et al 2011), CCN1 was shown to have elevated mRNA and protein expression in~85% of pancreatic cancer specimens compared to adjacent normal samples where expression was essentially absent. In cell lines, the highest expression of RNA and protein was detected in Panc-1 cells followed by AsPC-1, Capan-1 and BxPC-3.…”
mentioning
confidence: 97%
“…Its binding to cell-surface integrins promotes cancer cell proliferation and metastasis. Notably, overexpression of CYR61 in breast, prostate or ovarian cancer cells enhances tumour growth 21,22,40 , whereas CYR61 silencing in pancreatic and prostate cancer cells decreases tumour growth 22,23 . Finally, recombinant CYR61 treatment accelerates repair of epithelium in vitro in a model of inflammatory lung epithelium injury 41 .…”
Section: Discussionmentioning
confidence: 99%
“…Depending on the cell type and context, CYR61 can promote the proliferation, survival, migration or senescence of cells 14,[17][18][19][20] . CYR61 is overexpressed in various cancer cells, including cancers of epithelial origin, and can promote their proliferation [21][22][23] . Furthermore, specific expression of CYR61 in thymic stroma was evidenced in a study aimed at mapping thymic stromal gene expression 24 .…”
mentioning
confidence: 99%