Cyproterone acetate and ethinylestradiol-induced pill oesophagitis: a case report

Gülşen, Murat Taner; Buyukberber, N. Mehmet; Karaca, Mehmet; Kadayifci, A

doi:10.1111/j.1368-504x.2005.00350.x

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…A great variety of drugs are associated with esophageal injuries. Anti‐inflammatory analgesics (ibuprofen, indomethacin, aspirin, naproxen), quinidine, potassium chloride, emepronium bromide, doxycycline, tetracycline, clindamycin, ideocyclin, oxytetral ferrous sulphate, ascorbic acid, alprenolol chloride, theophylline, mycophenolate mofetil, warfarin, cyproterone acetate and ethinylestradiol, rifampin, cefotiam hydrochloride, phenytoin, have been reported as causative factors of DIO 2–10 …”

Section: Introductionmentioning

confidence: 99%

Drug-induced esophagitis

Zografos¹,

Georgiadou²,

Thomas

et al. 2009

Diseases of the Esophagus

122

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Drug-induced esophagitis is being recognized increasingly in the past few years. Since 1970 more than 650 cases have been reported worldwide caused by 30 or more medications. We have reviewed these cases with a view to classifying this disease based on underlying pathological mechanism. Drug-induced esophageal injury tends to occur at the anatomical site of narrowing, with the middle third behind the left atrium predominating (75.6%). The disease is broadly classified into two groups. The first group being transient and self-limiting as exemplified by the tetracycline group induced injury (65.8%). The second is the persistent esophagitis group, often with stricture, with two distinct entities: (i) patients on nonsteroidal anti-inflammatory agents whose injury is aggravated by gastroesophageal reflux (21.8%) (reflux aggravated); and (ii) patients with potasium chloride and quinidine sulphate induced injury (12.4%) (persistent drug injury). Severe esophageal injury has been reported in some women taking biphosphonates as treatment for postmenopausal osteoporosis. Endoscopic findings in such patients with esophageal injury generally suggested a chemical esophagitis, with erosions or ulcerations and exudative inflammation accompanied by thickening of the esophageal wall. Most cases of medication-induced esophageal injury heal without intervention within a few days. Thus, the most important aspect of therapy is to make the correct diagnosis and then to avoid reinjury with the drug. When possible, potentially caustic oral medications should be discontinued.

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Section: Introductionmentioning

confidence: 99%

Drug-induced esophagitis

Zografos¹,

Georgiadou²,

Thomas

et al. 2009

Diseases of the Esophagus

122

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“…Several other reports refer to esophageal injuries after medication intake. Iron tablets [2], doxycycline [3], cyproterone acetate and ethinylestradiol [4] are all described to have led to painful esophagitis. Even a presentation of esophageal cancer-like symptoms after doxycycline intake is described by Tahan et al [5].…”

Section: Discussionmentioning

confidence: 99%

Chemical gastritis after chronic bromazepam intake: a case report

et al. 2010

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BackgroundWe describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms.Case PresentationEndoscopy was performed in an 82-year-old patient due to gastroesophageal reflux symptoms and epigastric pain. Gastroscopy showed a hiatal hernia and a scarred duodenal bulb. More striking was the yellow-brownish discoloration of the gastric and the duodenal mucosa. The gastric antrum and the duodenal bulb showed local discoloration that could not be rinsed off. The medical history indicated that bromazepam (6 mg) had been used daily as a sleeping aid in the previous two years. The histopathological findings showed appearances of chemical gastritis. Within the lamina propria and on the epithelial surface there were granules. There was no foreign body reaction to these granules. Corpus mucosa showed a mild chronic gastritis.ConclusionsIf discoloration of the mucosa at endoscopy is seen, a careful drug history must be sought. This is the first case in literature that shows a chemical gastritis after bromazepam intake.

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Pill‐Induced Esophageal Injury

Young

Kikendall

2012

The Esophagus

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Cyproterone acetate and ethinylestradiol-induced pill oesophagitis: a case report

Cited by 9 publications

References 8 publications

Drug-induced esophagitis

Drug-induced esophagitis

Chemical gastritis after chronic bromazepam intake: a case report

Pill‐Induced Esophageal Injury

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