CyPA and Emmprin play a role in peri‐implantitis

Yang, Lei; Zhu, Qing; Gong, Jingjue; Xie, Ming; Jiao, Ting

doi:10.1111/cid.12549

Cited by 8 publications

(11 citation statements)

References 49 publications

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“…Isola et al, revealed the association between periodontitis in ischemic heart disease patients and the low serum and salivary vitamin C and antioxidant levels [12]. Whereas, a study showed that the Cyclophilin A may be an early signal for peri-implantitis [13]. In addition, the fibroblasts may be implicated in the PI pathogenesis by increasing the response to matrix breakdown and vascularity, consequently stimulating the promotion migration and preservation of infiltrates into the site [14].…”

Section: Introductionmentioning

confidence: 99%

Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces

et al. 2020

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(1) Background: The relatively high prevalence of peri-implantitis (PI) and the lack of a standard method for decontamination of the dental implant surface have pushed us to conduct further research in the field. Bacterial biofilms were found to play a primordial role in the etiology of PI. Therefore, the aim is to evaluate the efficacy of a laser-assisted elimination of biofilm protocol in the removal of a multi-species biofilm on titanium surfaces. (2) Methods: In total, 52 titanium discs (grade 4) were used. The study group consisted of 13 titanium disks contaminated with multi-species biofilms and subsequently irradiated with the laser (T + BF + L). The control groups consisted of the following types of titanium disks: 13 contaminated with multi-species biofilms (T + BF), 13 sterile and irradiated (T + L), 13 sterile and untreated (T). Q-Switch Nd:YAG laser Irradiation parameters were the following: energy density equal to 0.597 J/cm2 per pulse, power equal to 270 milliwatt per pulse, 2.4 mm of spot diameter, and 10 Hz repetition rate for pulse duration of six nanoseconds (ns). The laser irradiation was made during 2 s of total time in non-contact and at 0.5 mm away from the titanium disc surface. After treatment, presence of biofilms on the disks was evaluated by staining with crystal violet (CV), which was measured as optical density at six hundred thirty nm, and statistical analyses were done. (3) Results: the optical density values were 0.004 ± 0.004 for the study group T + BF + L, 0.120 ± 0.039 for group T + BF, 0.006 ± 0.003 for group T + L, and 0.007 ± 0.007 for group T. For the study group, laser treatment resulted in a total elimination of the biofilm, with mean values statistically significantly lower than those of contaminated titanium surfaces and similar to those of sterile titanium surfaces. (4) Conclusions: Our irradiation protocol provided a significant elimination of the multi-species biofilm on titanium surfaces. Laser treated titanium surfaces were biofilm-free, similar to the sterile ones.

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Section: Introductionmentioning

confidence: 99%

Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces

et al. 2020

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“…In the group ‘changed’, the ligatures were changed and replaced with a new after some time [ 19 – 21 , 23 – 25 , 28 , 32 , 35 , 36 , 38 , 41 – 43 , 47 , 52 , 53 ]. The group ‘unchanged’ [ 5 , 22 , 26 , 27 , 29 , 30 , 39 , 44 , 45 , 51 ] did not change the ligature that was inserted first, and the group ‘additional’ added multiple ligatures to the existing one [ 31 , 34 , 37 , 40 , 48 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…The progression of the defect depth caused by 8 weeks ranges from 1.6 mm [ 39 ] and 8 mm [ 50 ]. After 12 weeks, the lowest defect depth measured was 0.7 mm [ 29 ] and the highest was 5 mm [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

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Bone defect development in experimental canine peri-implantitis models: a systematic review

et al. 2022

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Purpose To provide a systematic overview of preclinical research regarding bone defect formation around different implant surfaces after ligature-induced peri-implantitis models in dogs. Two focused questions were formulated: ‘How much bone loss can be expected after a certain time of ligature induced peri-implantitis?’ and ‘Do different implant types, dog breeds and study protocols differ in their extent of bone loss?’ Materials and methods A systematic literature search was conducted on four databases (MEDLINE, Web of Science, EMBASE and Scopus). Observations, which consisted of bone defects measured directly after ligature removal in canine models, were included and analysed. Two approaches were used to analyse the relatively heterogeneous studies that fulfilled the inclusion criteria. First, separate simple linear regressions were calculated for each study and implant surface, for which observations were available across multiple time points. Second, a linear mixed model was specified for the observations at 12 weeks after ligature initiation, and assessing the potential influencing factors on defect depth was explored using lasso regularisation. Results Thirty-six studies with a total of 1082 implants were included after. Bone loss was determined at different time points, either with clinical measurements radiographically or histologically. Different implant groups [e.g. turned, sand-blasted-acid-etched (SLA), titanium-plasma-sprayed (TPS) and other rough surfaces] were assessed and described in the studies. A mean incremental defect depth increase of 0.08 mm (SD: −0.01–0.28 mm) per week was observed. After 12 weeks, the defect depths ranged between 0.7 and 5 mm. Based on the current data set, implant surface could not be statistically identified as an essential factor in defect depth after 12 weeks of ligature-induced peri-implantitis. Conclusion Expectable defect depth after a specific time of ligature-induced peri-implantitis can vary robustly. It is currently impossible to delineate apparent differences in bone loss around different implant surfaces.

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“…Recent years, Cyclophilin A (CyPA), an ubiquitous intracellular protein, has been recognized to be secreted into extracellular space by various cell types, such as macrophages, activated platelets (5). Moreover, extracellular CyPA exerts its in ammatory effects through binding to the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) in a celltype speci c manner (6). It is well-documented that extracellular CyPA is currently involved in the expression of adhesion molecules and induction of the in ammatory responses, including the chemotaxis of monocyte, neutrophile granulocytes, T lymphocytes, and eosinophile granulocytes (7,8).…”

Section: Introductionmentioning

confidence: 99%

Cyclophilin A/CD147 Induces the Epithelial-to-mesenchymal Transition and Renal Fibrosis in Chronic Allograft Dysfunction by Regulating MAPK Signaling

Liu

Tang

Jiang

et al. 2021

Preprint

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Objectives: Our study was designed to explore the role of Cyclophilin A (CyPA)/CD147 interactions in renal allograft fibrosis and chronic allograft dysfunction (CAD). Methods and materials: A rat renal transplant model with significant CAD was successfully identified. Renal allograft tissues and blood samples were collected. HE, Masson and immunohistochemistry staining were performed. Then human HK-2 cells were intervened by certain concentrations of CyPA, and total protein and mRNA were extracted. Western blot assay and PCR were performed to explore the protein and mRNA expression of CyPA, CD147 and epithelial-to-mesenchymal transition (EMT)-related biomarkers. CD147 siRNA and specific inhibitor of MAPK were used to explore the involved cellular mechanism.Results: We have successfully established and identified a 20-weeks renal transplant CAD model. We observed significant distributed and expressed CyPA and CD147 in the renal allograft fibrosis tissues. We also found the significant expression of CD147 and EMT-related markers in the HK-2 cells stimulated by CyPA. The CD147 siRNA confirmed the previous results in vitro. The selective inhibition of MAPK suggested the notable role of MAPK signaling pathway in the CyP/CD147 interactions involved in renal allograft fibrosis.Conclusions: Our study reported the positive relationship of CyPA/CD147 interactions with the renal allograft dysfunction. In vitro study suggested that CyPA could bind to CD147 and then induce the development of EMT process by MAPK signaling, thus contributing to the renal allograft fibrosis and CAD.

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CyPA and Emmprin play a role in peri‐implantitis

Abstract: Despite the limitations of this study, CyPA may be an early signal for peri-implantitis. A CyPA-Emmprin interaction exists in peri-implantitis and is Emmprin-dependent. Emmprin is related to clinical attachment loss in peri-implantitis.

Cited by 8 publications

References 49 publications

Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces

Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces

Bone defect development in experimental canine peri-implantitis models: a systematic review

Cyclophilin A/CD147 Induces the Epithelial-to-mesenchymal Transition and Renal Fibrosis in Chronic Allograft Dysfunction by Regulating MAPK Signaling

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