Abstract:Background Placental oxidative stress injury is considered to be a key cause of preeclampsia, but the specific molecules that regulate the balance between oxidant and antioxidant levels remain unclear. 20-Hydroxyeicosatetraenoic acid (20-HETE), an important cytochrome P450 family 4 subfamily A polypeptide 11 (CYP4A11)-dependent eicosanoids, has been proved to increase reactive oxygen species production. Whether CYP4A11/20-HETE is involved in the regulation of oxidant or antioxidant levels in preeclamptic place… Show more
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