CYP3A4-Mediated Metabolic Activation and Cytotoxicity of Chlortoluron
Xinxin Guo,
Mingyu Zhang,
Ya Li
et al.
Abstract:Chlortoluron (CTU) is an herbicide extensively used in agricultural settings for crop cultivation. Its presence in water has been identified as a pollutant detrimental to aquatic species. The objective of the present study was to explore the metabolic activation and hepatotoxicity of CTU. Through human and rat liver microsomal incubations supplemented with CTU, nicotinamide adenine dinucleotide phosphate (NADPH), and either glutathione or N-acetyl cysteine, a benzylic alcohol metabolite (M1) was discerned, alo… Show more
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