CYP3A Polymorphism and Chronic Mercury Intoxication

Chernyak, Yu. I.; Merinova, Alla P.

doi:10.1007/s10517-020-04738-4

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Therefore, in addition to accumulating Hg, children also accumulate important nutrients. However, the involvement of CYP3A in the development of Hg neurotoxic outcomes remains unclear [ 22 , 37 ]. It is important to highlight that high Hg contamination is a worrisome risk factor that may trigger disease processes independent of the presence of SNPs in genes associated with Hg metabolism and excretion.…”

Section: Discussionmentioning

confidence: 99%

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Perini,

Cardoso,

Knesse

et al. 2024

Toxics

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Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations. Observational and experimental studies were identified by screening three databases. Thirteen articles were included (quality score 82–100%) and 8124 individuals were evaluated. Hg exposure was mainly fish consumption (77%) and, in 31% of the studies, the Hg levels exceeded the reference limits. Genetic susceptibility to higher Hg levels and neurotoxicity risk in Hg poisoning were associated with eight (ALAD rs1800435, CYP3A4 rs2740574, CYP3A5 rs776746, CYP3A7 rs2257401, GSTP1 rs1695, MT1A rs8052394, MT1M rs2270836, and MT4 rs11643815) and three (MT1A rs8052394, MT1M rs2270837, and MT2A rs10636) SNPs, respectively, and rs8052394 was associated with both outcomes. The MT1A rs8052394 SNP may be used as a susceptibility biomarker to identify individuals at greater risk for higher Hg levels and the development of neurocognitive disorders in metal-exposed populations.

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Section: Discussionmentioning

confidence: 99%

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Perini,

Cardoso,

Knesse

et al. 2024

Toxics

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CYP3A1 metabolism-based neurotoxicity of strychnine in rat

Jiang

Lin

et al. 2022

Toxicology

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The role of anthropogenic dermatotoxicants in the etiology of acne in adolescents

Deryagina

Pilnik

Rejniuk

et al. 2023

Ekologiya cheloveka (Human Ecology)

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Abstract. Against the background of the steady pace of urbanization, the negative impact of anthropogenic toxic substances on human health is increasing every year. The most sensitive to the action of ecotoxicants is the child and adolescent organism. Given the acute reaction of the skin to the influence of toxic chemicals, aggravated by humoral changes in the body during puberty, the identification of criteria for the toxic etiology of acne is certainly relevant. The aim of the study was to determine the criteria of the predominantly toxicological mechanism of acne formation. To assess the effect of anthropogenic dermatotoxicants on the formation of acne, 595 children and various districts of the Moscow region were examined, of which 301 adolescents suffered from acne, and 294 practically healthy children made up the control group. The study used spectrometric, cytogenetic, biochemical and immunological research methods. The content of essential and toxic trace elements in adolescent hair samples was evaluated. A micronuclear test was performed in buccal epithelial cells. The testosterone level and the immunoregulatory index were evaluated. The results obtained in the study indicate at least two mechanisms of the formation of acne vulgaris in adolescents. The first is associated with a violation of the regulation of sex hormones, and the second with the dermatotoxicity of anthropogenic ecotoxicants. Adolescents with predominantly intoxicating etiology were characterized by low concentrations of selenium and zinc, high mercury and lead in hair samples, as well as an increase in the number of micronuclei in the buccal epithelium. Adolescents with predominantly hormonal etiology were characterized by an increase in testosterone levels and a decrease in the immunoregulatory index. At the same time, in adolescents with signs of genetic instability determined by the results of a micronucleus test, the clinical course of acne was significantly more severe than in children without pronounced karyopathology. Based on statistical processing of these data, prognostic algorithms were built to differentiate acne in adolescents by etiological factor. Thus, anthropogenic chemical toxicants, represented mainly by heavy metal salts, have an aggravating effect on the formation and course of acne in adolescents.

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CYP3A Polymorphism and Chronic Mercury Intoxication

Cited by 4 publications

References 12 publications

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

CYP3A1 metabolism-based neurotoxicity of strychnine in rat

The role of anthropogenic dermatotoxicants in the etiology of acne in adolescents

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